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| 1 | Efficacy of long term cyclic administration of the poorly absorbed antibiotic Rifaximin in symptomatic,uncomplicated colonic diverticular disease显示文摘AIM: To comparatively evaluate the long term efficacy of Rifaximin and dietary fibers in reducing symptoms and/or complication frequency in symptomatic, uncomplicated diverticular disease. METHODS: 307 patients (118 males, 189 females, age range: 40-80 years) were enrolled in the study and randomly assigned to: Rifaximin (400 mg bid for 7 d every month) plus dietary fiber supplementation (at least 20 gr/d) or dietary fiber supplementation alone. The study duration was 24 mo; both clinical examination and symptoms’ questionnaire were performed every two months. RESULTS: Both treatments reduced symptom frequency, but Rifaximin at a greater extent, when compared to basal values. Symptomatic score declined during both treatments, but a greater reduction was evident in the Rifaximin group (6.4 ± 2.8 and 6.2 ± 2.6 at enrollment, P = NS, 1.0 ± 0.7 and 2.4 ± 1.7 after 24 mo, P < 0.001, respectively). Probability of symptom reduction was higher and complication frequency lower (Kaplan-Meyer method) in the Rifaximin group (P < 0.0001 and 0.028, respectively). CONCLUSION: In patients with symptomatic, uncomplicated diverticular disease, cyclic administration of Rifaximin plus dietary fiber supplementation is more effective in reducing both symptom and complication frequency than simple dietary fiber supplementation. Long term administration of the poorly absorbed antibiotic Rifaximin is safe and well tolerated by the patients,confirming the usefulness of this therapeutic strategy in the overall management of diverticular disease. | Antonio Colecchia Amanda Vestito Francesca Pasqui Giuseppe Mazzella Enrico Roda Francesca Pistoia Giovanni Brandimarte Davide Festi | 2007 | World Journal of Gastroenterology2007，13，2： | 21 |
| 2 | Body weight, lifestyle, dietary habits and gastroesophageal reflux disease显示文摘While lifestyle modifications are currently used as firstline treatment for subjects with gastroesophageal reflux disease (GERD), the pathogenetic role of lifestyle factors and consequently, the efficacy of lifestyle measures is controversial. Our aim was to systematically review the pathogenetic link between overweight/ obesity, dietary habits, physical activity and GERD, and the beneficial effect of specific recommended changes, by means of the available literature from the 1999 to the present. Obesity, in particular, abdominal obesity, plays a key role in determining GERD symptoms and complications through mechanical and metabolic effects. Controlled weight loss (by diet or surgery) is effective in improving GERD symptoms. No definitive data exist regarding the role of diet and, in particular, of specific foods or drinks, in influencing GERD clinical manifestations. Moderate physical activity seems to be beneficial for GERD, while vigorous activity may be dangerous in predisposed individuals. In conclusion, being obese/overweight and GERD-specific symptoms and endoscopic features are related, and weight loss significantly improves GERD clinical-endoscopic manifestations. The role of dietary behavior, mainly in terms of specific dietary components, remains controversial. Mild routine physical activity in association with diet modifications, i.e. a diet rich in fiber and low in fat, is advisable in preventing reflux symptoms. | Davide Festi Eleonora Scaioli Fabio Baldi Amanda Vestito Francesca Pasqui Anna Rita Di Biase Antonio Colecchia | 2009 | World Journal of Gastroenterology2009，15，14： | 8 |
| 3 | Time-dependent effect of statins on platelet function in hypercholesterolaemia显示文摘 | Puccetti L Pasqui AL Pastorelli M | 2002 | Eur J Clin Invest2002，32，： | 1 |
| 4 | Platelet hyperactivity after statin treatment discontinuation 显示文摘 | Puccetti L Pasqui AL Pastorelli M | 2003 | Thromb Haemost2003，90，47： | 1 |
| 5 | Effect of atorvastatin on differ- ent fibrinolyis mechanisms in hypercholesterolemic subjects显示文摘 | Bruni F Pasqui AL Pastorelli M | 2004 | Int J Cardiol2004，95，23： | 1 |
| 6 | POEMS sydrome with vascular lesions:a role forinterleukin-1beta and interleukin-6 increase-a case report显示文摘 | Bova G,Pasqui AL,Saletti M | 1998 | Angiology1998，，： | 1 |
| 7 | Platelet hyperactivity after statin treatment discontinuation 显示文摘 | Puccetti L Pasqui AL PastroreUi M | 2003 | Thromb Haemost2003，90，3： | 1 |
| 8 | Ablative strategy: a definite treatment for cardiac arrhythmias 显示文摘 | Hocini M Pasquie J L Jais P | 2004 | Rev Prat2004，54，3： | 1 |
| 9 | Endoscopic lithotripsy and the FREDDY laser:initial experience显示文摘 | DUBOSQ F PASQUI F GIRARD F | 2006 | J Endourol2006，20，5： | 1 |
| 10 | Technique and complications of transurethral surgery for bladder tumours显示文摘 | TRAXER O PASQUI F GATTEGNO B | 2004 | BJU Int2004，94，4： | 1 |
| 11 | POEMS syndrome with vascu- lar lesions : a role for interleukin - 1 beta and interleukin - 6 in- crease : a ease report显示文摘 | Bova G Pasqui AL Saletti M | 1998 | Angio[ogy1998，49，11： | 1 |
| 12 | POEMS syndrome with vascular lesions: a role for interleukin 1 beta and interleukin-6 increase - a case report 显示文摘 | Bova G Pasqui AL Saletti M | 1998 | Angiology1998，49，11： | 1 |
| 13 | Safety, feasi- bility,and outcome results of cardiac resynchronization with triple-site ventricular stimulation compared to con- ventional cardiac resynchronization显示文摘 | Anselme F Bordachar P Pasquie JL | 2016 | Heart Rhythm2016，13，1： | 1 |
| 14 | Cytokines in acute coronary syndromes显示文摘 | PASQUI A L DI RENZO M AUTERI A | 2005 | Int J Cardiol2005，105，3： | 1 |
| 15 | POEMS syndrome with vascular lesions:a role for interleukin-1 beta and interleukin-6 increase a case report显示文摘 | Bova G Pasqui Al SalettiM | 1998 | Angiology1998，49，11： | 1 |
| 16 | Pidotimod, a new biological response modifier, is able to partially prevent immune response changes related to surgical stress 显示文摘 | Pasqui AL Bruni F di Renzo M | 1993 | Drugs Exp Clin Res1993，，： | 1 |
| 17 | POEMS syndrome with vascular lesions and renal carcinoma-possible role of cytokines 显示文摘 | Pasqui AL Bova G Saletti M | 1998 | Eur J Med Res1998，3，6： | 1 |
| 18 | Platelet hyperactivity after statin treatment diseontinuation 显示文摘 | Puccetti L Pasqui AL Pastorelli M | 2003 | Thromb Haemost2003，90，3： | 1 |
| 19 | Pro-inflammatory/anti-inflammatory cytokine imbalance in acute coronary syndromes显示文摘 | PASQUI A L DI RENZO M BOVA G | 2006 | Clin Exp Med2006，6，1： | 1 |
| 20 | The in vitro effect of Pidotimod on some immune functions in cancer patients 显示文摘 | Di Renzo M Pasqui AL Bruni F | 1997 | Immunopharma Immunot1997，19，1： | 1 |
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