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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | The plasminogen activation system in tumor gowth,invasion,and metastasis显示文摘 | Egelund R Petersen HH | 2000 | Cell Moll Life Sci2000，57，1： | 1 |
| 3 | Insulin resistance of muscle glucose transport in rats fed a high-fat diet: a reevaluation显示文摘 | Han DH Hansen PA Host HH | 1997 | Diabetes1997，46，11： | 1 |
| 4 | Push-out bond strengths of the dentine-sealer interface with and without a main cone显示文摘 | Jainaen A Pa|amara JE Messer HH | 2007 | Int Endod J2007，40，11： | 1 |
| 5 | Anterior decompression and arthrodesis of the cervical spine: long-term motor improvement (Part I): improvement in incomplete traumatic quadrilSaresis显示文摘 | Bohlman HH Anderson PA | 1992 | J Bone Joint Surg Am1992，74，2： | 1 |
| 6 | Charac- terization of a large Lebanese family segregating IgA nephropathy显示文摘 | Karnib HH Sanna-Cherchi S Zalloua PA | 2007 | Nephrol Dial Transplant2007，22，3： | 1 |
| 7 | The plasminolgen a-activation systetn in tumor growth, imasion, and metastasis显示文摘 | Ndreaaon PA Egelund R Petersen HH | 2000 | Cell nol Life sci2000，57，1： | 1 |
| 8 | Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D显示文摘 | Price PA June HH Buckley JR | 2001 | Arterioscler Thromb Vasc Biol2001，21，10： | 1 |
| 9 | Usefulness of bone miner-al density to predict significant coronary artery diseasese显示文摘 | Marcovitz PA Tran HH Franklin BA | 2005 | Am JCardiol2005，96，8： | 1 |
| 10 | G-protein-coupled receptor-signa-ling components inmembrane raft and caveolae microdomains 显示文摘 | PateI HH Murray F lnsel PA | 2008 | Handb Exp Pharmacol2008，186，： | 1 |
| 11 | The plasminogen activation system in tumor growth, invasion, and metastasis 显示文摘 | Andreasen PA Egelund R Petersen HH | 2000 | Cell Mol Life Sci2000，57，： | 1 |
| 12 | Caveolae as organizers of pharmacologically relevant signal transduction molecules 显示文摘 | Patel HH Murray F Insel PA | 2008 | Annu Rev Pharmacol Toxicol2008，48，： | 1 |
| 13 | Caveolin as organizers of pharmacologically relevant original transduction molecules 显示文摘 | Patel HH Murray F Insel PA | 2008 | Annu Rev Pharmacol Toxico12008，48，4： | 1 |
| 14 | Osteoprotegerin inhibits ar?tery calcification induced by warfarin and by vitamin D显示文摘 | Price PA June HH Buckley JR | 2001 | Arterio?scler Thromh Vasc BioI2001，21，10： | 1 |
| 15 | Osteoprotegerin Inhibits Artery Calcification Induced by Warfarin and by Vitamin D显示文摘 | June HH Buckley JR | 2001 | Arterioscler Thromb Vasc Biol2001，21，： | 1 |
| 16 | Compartmentation of G-proteincoupled receptors and their signalling components in lipid rafts andcaveolae显示文摘 | Insel PA Head BP Patel HH | 2005 | Biochem Soc Trans2005，33，5： | 1 |
| 17 | Caveolae as organizers of pharma- cologically relevant signal transduction molecules 显示文摘 | Patel HH Murray F Insel PA | 2008 | Annu Rev Pharmacol Toxicol2008，48，： | 1 |
| 18 | Lipid rafsand caveolae and their role in comp- artmentation of redox signaling显示文摘 | Patel HH Insel PA | 2009 | Antioxid Redox Signal2009，11，6： | 1 |
| 19 | The plasminogen activation system in tumor growth, invasion, and metastasis显示文摘 | Andreasen PA Egelund R Petersen HH | 2000 | Cell Mol Life Sci2000，57，1： | 1 |
| 20 | Verification of the introgression of Erianthus arundinaceus germplasm into sugarcane using molecular markers显示文摘 | Cai Q Aitken K Deng HH Chen XW Fu C Jackson PA Mcintyre CL | 2005 | Plant Breeding2005，124，4： | 1 |
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