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| 1 | Reprogramming the host: Modification of cell functions upon viral infection显示文摘Viruses and their hosts have co-evolved for million years. In order to successfully replicate their genome, viruses need to usurp the biosynthetic machinery of the host cell. Depending on the complexity and the nature of the genome, replication might involve or not a relatively large subset of viral products, in addition to a number of host cell factors, and take place in several subcellular compartments, including the nucleus,the cytoplasm, as well as virus-induced, rearranged membranes. Therefore viruses need to ensure the correct subcellular localization of their effectors and to be capable of disguising from the cellular defensive mechanisms. In addition, viruses are capable of exploiting host cell activities, by modulating their post-translational modification apparatus, resulting in profound modifications in the function of cellular and viral products. Not surprisingly infection of host cells by these parasites can lead to alterations of cellular differentiation and growing properties, with important pathogenic consequences. In the present hot topic highlight entitled 'Reprogramming the host: modification of cell functions upon viral infection', a number of leading virologists and cell biologist thoroughly describe recent advances in our understanding of how viruses modulate cellular functions to achieve successful replication and propagation at the expenses of human cells. | Gualtiero Alvisi Giorgio Palù | 2013 | World Journal of Virology2013，2，2： | 0 |
| 2 | Evaluation of a near-patient test and 2 enzyme-linked immunosorbent assay-based assays for detecting anti-herpes simplex virus type-2 antibodies显示文摘 | Palù G Calistri A Cancellotti E | 2001 | Scand J Infect Dis2001，33，10： | 1 |
| 3 | Human papillomavirus sperm infection and assisted reproduction: A dangerous hazard with a possible safe solution显示文摘 | Garolla A Lenzi A Palù G | 2012 | Human Reprod2012，27，4： | 1 |
| 4 | Intra-hepatic cholestasis of pregnancy in hepatitis C virus infection显示文摘 | Paternoster DM Fabris F Palù G | | Acta Obstetricia Et Gynecologica Scandinavica0，，： | 1 |
| 5 | Quinolone binding to DNA is mediated by magnesium ions显示文摘 | Palù G Valisena S Ciarrochi G | 1992 | Proc Natl Acad Sci USA1992，89，： | 1 |
| 6 | Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to aids therapy- 显示文摘 | Richter SN Frasson I Palù G | 2009 | Curr Med Chem2009，16，： | 1 |
| 7 | Viral proteins and Src family kinases: Mechanisms of pathogenicity from a “liaison dangereuse”显示文摘To complete their life cycle and spread, viruses interfere with and gain control of diverse cellular processes, this most often occurring through interaction between viral proteins(VPs) and resident protein partners. Among the latter, Src family kinases(SFKs), a class of non-receptor tyrosine kinases that contributes to the conversion of extracellular signals into intracellular signaling cascades and is involved in virtually all cellular processes, have recently emerged as critical mediators between the cell's infrastructure and the viral demands. In this scenario, structural or ex novo synthesized VPs are able to bind to the different domains of these enzymes through specific short linear motifs present along their sequences. Proline-rich motifs displaying the conserved minimal consensus PxxP and recognizing the SFK Src homology(SH)3 domain constitute a cardinal signature for the formation of multiprotein complexes and this interaction may promote phosphorylation of VPs by SFKs, thus creating phosphotyrosine motifs that become a docking site for the SH2 domains of SFKs or other SH2 domain-bearing signaling molecules. Importantly, the formation of these assemblies also results in a change in the activity and/or location of SFKs, and these events are critical in perturbing key signalingpathways so that viruses can utilize the cell's machinery to their own benefit. In the light of these observations, although VPs as such, especially those with enzyme activity, are still regarded as valuable targets for therapeutic strategies, multiprotein complexes composed of viral and host cell proteins are increasingly becoming objects of investigation with a view to deeply characterize the structural aspects that favor their formation and to develop new compounds able to contrast viral diseases in an alternative manner. | Mario Angelo Pagano Elena Tibaldi Giorgio Palù Anna Maria Brunati | 2013 | World Journal of Virology2013，2，2： | 3 |
| 8 | Viral load in HCV RNA-positive pregnant women显示文摘 | D.M Paternoster C Santarossa P Grella G Palù V Baldo P Boccagni A Floreani | 2001 | The American Journal of Gastroenterology2001，，9： | 1 |
| 9 | Mechanisms of macrolide resistance in Ureaplasma urealyticum: A study on collection and clinical strains显示文摘 | G. Palù S. Valisena M. F. Barile G. A. Meloni | 1989 | European Journal of Epidemiology1989，，2： | 1 |
| 10 | Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy显示文摘 | Menegazzi Paola Barzon Luisa Palù Giorgio Reho Elisa Tagliaferro Luigi | 2009 | Infectious Diseases in Obstetrics and Gynecology2009，，： | 1 |
| 11 | Esophageal achalasia: Is the herpes simplex virus really innocent?显示文摘 | Ignazio Castagliuolo Paola Brun Mario Costantini Christian Rizzetto Giorgio Palù Michela Costantino Nicola Baldan Giovanni Zaninotto | 2004 | Journal of Gastrointestinal Surgery2004，，1： | 1 |
| 12 | Endogenous Interferon-α Level is Increased in Hepatitis C Virus (HCV)-Positive Pregnant Women显示文摘 | Delia Maria Paternoster Anna Belligoli Nanhornguè Kimta Ngaradoumbe Silvia Visentin Riccardo Franco Stefano Fagiuoli Caterina Boldrin Giorgio Palù Vincenzo Baldo Annarosa Floreani | 2008 | Journal of Clinical Gastroenterology2008，，2： | 1 |
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