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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 肝泡型包虫病临床分期与sIL-2R、TNF-α和IFN-γ含量的关系显示文摘为探讨肝泡型包虫病 (Alveolar echinococcosis AE)临床分期与 s IL- 2 R,TNF- α和 IFN- γ含量的关系和意义 ,将经B超和血清学方法证实的 2 3例 AE病人和对照组 1 2人采血后 ,用 ELISA双抗体夹心法 ,做 s IL- 2 R,TNF-α和 IFN-γ含量的测定。按 B超肝脏扫描的声像损害情况 ,将 AE分期 (组 ) ,对照相应细胞因子的含量 ,经方差分析和 Q检验 ,讨论细胞因子在 AE发育增殖中的可能作用和临床意义。结果 P2 组、P3 组、P4组和对照组 s IL- 2 R每 m L含量均值分别为 96.57u、2 2 6.44u、1 93.81 u、1 1 0 .89u;TNF- α含量均值分别为 P2 组 1 .1 2 μg/ L,P3 组 3.67μg/ L,P4组 1 .30 μg/ L,对照组则为 0 .40μg/ L;IFN-γ含量均值分别为 P2 组 360 ng/ L,P3 组 486 ng/ L,P4组 2 59ng/ L,对照组则为 1 5.63 ng/ L;各组经方差分析和 Q检验 ,证实 AE病人病理的三个不同时期 ,其 s IL- 2 R,TNF- α和 IFN- γ的含量均有显著性差异 (P<0 .0 1 )。 s IL- 2 R含量均值除 P2 与对照组无差异外 (P>0 .0 5) ,其余各组与 P2 组和对照组均有显著性差异 (P<0 .0 5) ;TNF- α含量在 P3 组最高 (P<0 .0 1 ) ;AE各组病人的 IFN- γ含量明显高于对照组 (P<0 .0 1 ) ,而 AE病人组间却并无差异 (P>0 .0 5)。低水平的 s IL- | 史大中 李富荣 B Bartholomot DA Vuitton PS Craig | 2001 | 地方病通报2001，16，4： | 4 |
| 3 | 一般人群中腹型肥胖和新发心房颤动的关系显示文摘已知身高越高,体质量越大,心房颤动发生风险越高。然而,心房颤动的风险是否与腹型肥胖有关尚不清楚。Baek等纳入韩国国民健康保险计划全国样本队列中基线无心房颤动的成人501 690人,年龄(47.6±14.3)岁,女性250 664人,占50%。测定其体质量指数(body mass index,BMI)和腰围,将BMI〈18.5kg/m2定义为低体质量,18.5~〈25.0kg/m2定义为正常体质量;25.0~〈30.0kg/m2定义为超重;≥30.0kg/m2定义为肥胖;将腰围≥90(男性)和≥80cm(女性)定义为腹型肥胖。 | 刘莉 叶鹏 Baek YS Yang PS Kim TH Uhm JS Park J Pak HN Lee MH Joung B | 2017 | 中华高血压杂志2017，25，9： | 4 |
| 4 | Serum sIL-2R,TNF-α and IFN-γ in alveolar echinococcosis显示文摘AIM: To approach the relationship between alveolar echinococcosis (AE) pathology and level of sIL-2R,TNF-α and IFN-γ in sera and the significance of cytokines in development of AE.METHODS: After 23 patients with AE were confirmed by ELISA and ultrasound, their sera were collected and the concentrations of sIL-2R,TNF-α and IFN-γ were detected by double antibody sandwich. Twelve healthy adults served as controls. According to the status of livers of AE patients by ultrasound scanning, they were divided into 4 groups: P2,P3, P4 groups and C group (control). Average of concentrations of sIL-2R, TNF-α and IFN-yin homologous group was statistically analyzed by both ANOV and Newman-Keuls, respectively.RESULTS: The mean of sIL-2R in P2 group was 97±29, P3:226±80, P4:194±23 and control group (111±30)×10^3 u/L(P<0.01). The mean of TNF-α in P2 group was 1.12±0.20, P3:3.67±1.96, P4:1.30±0.25 and control group 0.40±0.19 μg/L(P<0.01). The mean of IFN-γ in P2 group was 360±20, P3:486±15, P4:259±19 and control group: 16±2 ng/L (P<0.01).Judged by ANOV and Newman-Keuls, the mean concentrations of sIL-2R, TNF-α and IFN-γ had a significant difference among groups. Except for P2group, the mean sIL-2R between other groups of AE patients had a significant difference (P<0.05). The mean of TNF-α concentration in P3 group was the highest (P<0.01). The mean of IFN-γ concentration in all patients was higher than that in control group (P<0.01),but there was no difference between AE groups (P>0.05).CONCLUSION: Low sIL-2R level indicates an early stage of AE or stable status, per contra, a progression stage. Higher level of TNF-α might be related to the lesion of liver. The role of single IFN-γ is limited in immunological defense against AE and it can not fully block pathological progression. | Da-Zhong Shi Fu-Rong Li B Bartholomot DA Vuitton PS Craig | 2004 | World Journal of Gastroenterology2004，10，24： | 3 |
| 5 | 肝泡球蚴病超声声象类型及病理分型与血清sIL-2R的关系显示文摘B 超对肝占位性病变的诊断具有直观和定位准确的特点,已被用作临床病理分型的主要手段.随着 B 超在泡球蚴病诊断和流行病学中应用的普及,泡球蚴病超声象的分型及临床分型日益受到重视.但直到现在对其声象类型仍有分歧.Hadni 参照肝癌的分型标准,将泡球蚴分为3种临床类型。 | 史大中 李富荣 B Bartholomot PS Craig DA Vuitton | 2000 | 世界华人消化杂志2000，8，7： | 2 |
| 6 | The anglo-scandinavian cardiac outcomes trial lipid lowering arm: extended observations 2 years after trial closure显示文摘 | Sever PS Poulter NR Dahlof B | 2008 | Eur Heart J2008，29，4： | 1 |
| 7 | Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes:principal results of the Conduit Artery Function evaluation (CAFE) Study显示文摘 | Willinams B Lacv PS Thom SM | 2006 | Circulation2006，113，9： | 1 |
| 8 | Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations,in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm(ASCOT-LLA):a multi centre randomised controlled trial显示文摘 | Sever PS Dahl(o)f B Poulter N | 2003 | Lancet2003，361，9364： | 1 |
| 9 | Natrelle saline-filled breast implants:a prospective 10-year study显示文摘 | Walker PS Walls B Murphy DK | 2009 | Aesthet Surg J2009，29，1： | 1 |
| 10 | Nitric oxide regulates monocyte chemotactic protein-1 显示文摘 | Tsao PS Wang B Buitrago R | 1997 | Circulation1997，96，3： | 1 |
| 11 | Urea cycle disorders:clinical presentation outside the newborn period 显示文摘 | Smith W Kishnani PS Lee B | 2005 | Crit CareClin2005，21，4： | 1 |
| 12 | Autoimmune thyroid dis- ease in Indian children with type 1 diabetes mellitus显示文摘 | Menon PS Vaidyanathan B Kaur M | 2001 | J Pediatr Endocrinol Metab2001，14，3： | 1 |
| 13 | ACCF/ASE/ ACEP/ASNC/SCAI/SCCT/SCMR 2007 appropriateness criteria for transthoracic and transesophageal echocardiography显示文摘 | Douglas PS Khandheria B Stainback RF | | 0，，： | 1 |
| 14 | Dedifferentiated chon drosarcoma:the role of chemotherapy with updated out- comes 显示文摘 | Dickey ID Rose PS Fuchs B | 2004 | J Bone Joint Surg Am2004，86，11： | 1 |
| 15 | The prevalence of undiagnosed re- nal failure in a cohort of COPD patients in western Norway 显示文摘 | Gjerde B Bakke PS Ueland T | 2012 | Respir- atory medicine2012，106，3： | 1 |
| 16 | Development and evaluation of a novel floating in situ gelling system of amoxicillin for eradication of Helicobacter pylori显示文摘 | Rajinikanth PS Balasubramaniam J Mishra B | 2007 | Int J Pharm2007，335，12： | 1 |
| 17 | Human metapneunmvirus in severe respiratory syncytial virus bronchiolitis 显示文摘 | Greensill J McNamara PS Dove W Flanagan B Smyth RL Hart CA | 2003 | Emerg Infect Dis2003，9，3： | 1 |
| 18 | The neurotrophins BDNF,NT-3,and NG F display distinct patterns of retrograd e axonal transport in peripheral and cen teral neurons显示文摘 | Distefano PS Friedman B Radziejewskic | 1992 | Nuron1992，8，： | 1 |
| 19 | Development and evaluation of a novel floating in situ gelling system of amoxicillin for eradication of Helicobacter pylori 显示文摘 | Rajinikanth PS Balasubramaniam J Mishra B | 2007 | Int J Pharm2007，335，12： | 1 |
| 20 | Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than average cholesterol concentrations, in the Anglo-Scandinavian Crdiac Outcome Trial-Lipid Lowering Arm (ASCOT-LLA): a muhicentre randomized controlled trial 显示文摘 | Sever PS Dahlof B Pouher NR | 2003 | Lancet2003，361，： | 1 |
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