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| 1 | Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) F.Muell in streptozotocin—induced diabetic rats显示文摘Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models.Methods:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg p.o.while hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg p.o.per day for 21 days in Streptozotocin(STZ) induced diabetic rats.Further,glucose uptake by hemidiaphram was also evaluated.The total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also determined.Results:The results showed high level of phenolic content in AHE.AHE also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and deoxyribose.Furthermore there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the AHE.AHE increased glucose uptake on isolated rat hemi-diaphragm compared to control group.Conclusions:AHE reduce blood glucose level in STZ-induced diabetic model.It does not show significant effect in normoglycemic study but showes significant effect in OGT.AHE has significant antioxidant activity,which may be attributed to high phenolic content. | Patel DK Kumar R Prasad SK Sairam K Hemalatha S | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 22 |
| 2 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 3 | Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus:A pilot ex-vivo study显示文摘AIM:To investigate a classification of endocytoscopy(ECS)images in Barrett’s esophagus(BE)and evaluate its diagnostic performance and interobserver variability.METHODS:ECS was applied to surveillance endoscopic mucosal resection(EMR)specimens of BE ex-vivo.The mucosal surface of specimen was stained with 1%methylene blue and surveyed with a catheter-type endocytoscope.We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation.The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS.RESULTS:Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures(two images per each classification)into one of four histopathologic categories as follows:(1)BEC1-squamous epithelium;(2)BEC2-BE without dysplasia;(3)BEC3-BE with dysplasia;and(4)BEC4-esophageal adenocarcinoma(EAC)in BE.Accuracy of diagnosis in staff physicians and clinical fellows were,respectively,100%and 99.4%for BEC1,95.8%and83.0%for BEC2,91.7%and 83.0%for BEC3,and95.8%and 98.3%for BEC4.Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897,respectively.CONCLUSION:This is the first study to investigate classification system of ECS in BE.This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. | Yutaka Tomizawa Prasad G Iyer Louis M Wongkeesong Navtej S Buttar Lori S Lutzke Tsung-Teh Wu Kenneth K Wang | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 4 | Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population显示文摘Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field. | Frances M Mitchell Sanjay K Prasad Gerald F Greil Peter Drivas Vassilios S Vassiliou Claire E Raphael | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 2 |
| 5 | Treatment of simulated Reactive Yellow 22 (Azo) dye effluents using Spirogyra species 显示文摘 | Mohan S V Rao N C Prasad K K J | 2002 | Waste Management2002，22，6： | 1 |
| 6 | Simulation of Frontal Barrier Offset Impacts and Comparison of Intrusions and Decelerations 显示文摘 | SAHA N K CALSO S M PRASAD P | 1995 | SAE Transactions1995，104，1： | 1 |
| 7 | A 75 ka record of palaeoclimatic changes inferred from crystallinity of illite from Nal Sarovar, western India 显示文摘 | Pandarinath K Prasad S Gupta S K | 1999 | J Geol Soc India1999，54，5： | 1 |
| 8 | Modular product design: A life cycle view 显示文摘 | GERSHENSON J K PRASAD G J ALLAMNENI S | 1999 | Journal of Integrated Design and Process Science1999，3，4： | 1 |
| 9 | Purification and partial chara -ctcrization of thcrmostablc scrinc alkaline protease from a newly isolated Bacillus subtilis PE-11 显示文摘 | ADINARAYANA K ELLAIAH P PRASAD D S | 2003 | AAPS Pharmaceutical Science and Technology2003，4，4： | 1 |
| 10 | Zinc biosorption on Tectona grandis L leaves biomass:Equilibrium and kinetic studies显示文摘 | Kumar Y P King P Prasad V S R K | 2006 | Chemical Engineering Journal2006，124，1： | 1 |
| 11 | Effect of zine on free radicals and proline in Brassica and Cajanus显示文摘 | Alia K V Prasad S K Saradhi P P | 1995 | Phytochemistry1995，39，： | 1 |
| 12 | Effect of zinc on free radicals and proline in Brassica and Cajanus显示文摘 | Alia Prasad K V S K Saradhi P P | 1995 | Phytochemistry1995，39，1： | 1 |
| 13 | Voltammetric sensor for barbituric acid based on a solgel derivated molecularly imprinted polymer brush grafted to graphite electrode显示文摘 | PATEL A K SHARMA P S PRASAD B B | 2009 | International Journal of Pharmaceutics2009，371，1： | 1 |
| 14 | Experimen- tal study of an air-cooled thermal rnanagement system for high capacity lithium-titanate batteries 显示文摘 | Giuliano M R Ajay Prasad K Advani S G | 2012 | Journal of Power Sources2012，216，： | 1 |
| 15 | Micro- structural Modeling of Metadynamic Recrystallization in Hot Working of In718 Superalloy 显示文摘 | Medeiros S C Prasad Y V R K Frazier W G | 2000 | Materials Science and Engineering2000，293，： | 1 |
| 16 | Drying kinetics and rehydration characteristics of microwave-vacuum and convective hot-air dried mushrooms显示文摘 | GIRI S K PRASAD S | 2007 | Journal of Food Engineering2007，78，2： | 1 |
| 17 | Treatment of Simulated Reactive Yellow 22 (Azo) Dye Effluents Using Spirogyra Species 显示文摘 | VENKATA MOHAN S CHANDRASEKHAR RAO N KRISHNA PRASAD K KARTHIKEYAN J | 2002 | Waste Management2002，22，： | 1 |
| 18 | Treatment of complex chemical wastewater in a sequencing batch reactor (SBR) with an aerobic suspended growth configuration显示文摘 | Venkata Mohan S Chandrashekara Rao N Krishna Prasad K | 2005 | Process Biochemistry2005，40，15： | 1 |
| 19 | Enhanced tolerance to photoinhibition in transgenic plants through targeting of glycinebetaine biosynthesis into the chloroplasts显示文摘 | Prasad K V S K Saradhi P P | 2004 | Plant Science2004，166，5： | 1 |
| 20 | Hot working of commercial Ti-6A1-4V with an equiaxed a-β microstructure: materials modeling considerations 显示文摘 | Seshacharyulu T Medeiros S C Prasad Y V R K | 2000 | Materials Science and Engineering2000，284，： | 1 |
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