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| 1 | Cerebrovascular reactivity mapping for brain tumor presurgical planning显示文摘This article provides a review of Blood Oxygen Level Dependent functional magnetic resonance imaging(BOLD fMRI)applications for presurgical mapping in patients with brain tumors who are being considered for lesion resection.Initially,the physical principle of the BOLD effect is discussed,followed by a general overview of the aims of presurgical planning.Subsequently,a review of sensorimotor,language and visual paradigms that are typically utilized in clinical fMRI is provided,followed by a brief description of studies demonstrating the clinical impact of preoperative BOLD fMRI.After this thorough introduction to presurgical fMRI,a detailed explanation of the phenomenon of neurovascular uncoupling(NVU),a major limitation of fMRI,is provided,followed by a discussion of the different approaches taken for BOLD cerebrovascular reactivity(CVR)mapping,which is an effective method of detecting NVU.We then include one clinical case which demonstrates the value of CVR mapping in clinical preoperative fMRI interpretation.The paper then concludes with a brief review of applications of CVR mapping other than for presurgical mapping. | Domenico Zaca Jun Hua Jay J Pillai | 2011 | World Journal of Clinical Oncology2011，2，7： | 7 |
| 2 | Clinical utility of cerebrovascular reactivity mapping in patients with low grade gliomas显示文摘AIM:To evaluate neurovascular uncoupling(NVU)associated with low grade gliomas(LGG)using blood oxygen level dependent(BOLD)cerebrovascular reactivity mapping.METHODS:Seven patients with low grade gliomas referred by neurosurgeons for presurgical mapping were included in this pilot study.Cerebrovascular reactivity(CVR)mapping was performed by acquiring BOLD images while patients performed a block-design breath-hold(BH)hypercapnia task.CVR mapping was expressed as BOLD percentage signal change(PSC)from baseline associated with performance of the BH hypercapnia task.Standard T2*Dynamic Susceptibility Contrast perfusion imaging was performed and relative cerebral blood volume(rCBV)and relative cerebral blood flow(rCBF)maps were generated.Structural T1 weighted MR images were also acquired.A correlation analysis between intratumoral normalized(via ratio with contralateral homologous regions)BOLD BH PSC[referred to as(nCVR)]and intratumoral normalized resting state rCBV(rCBF)values(i.e.,nCBV and nCBF,respectively)was performed.RESULTS:No significant correlation was seen between the normalized BOLD BH PSC(i.e.,nCBV)and nCBV or nCBF.However,the average nCVR(median=0.50,z=-2.28,P=0.01)was significantly less than 1.0,indicating abnormally reduced vascular responses in the tumor regions relative to normal contralesional homologous regions,whereas the average nCBV(median=0.94,z=-0.92,P=0.375)and nCBF(median=0.93,z=-1.16,P=0.25)were not significantly higher or lower than 1.0,indicating iso-perfusion in the tumor regions relative to normal contralesional homologous regions.These findings suggest that in LGG,hyperperfusion that is seen in high grade gliomas is not present,but,nevertheless,abnormally decreased regional CVR is present within and adjacent to LGG.Since the patients all demonstrated at least some residual function attributable to the cortical regions of impaired CVR,but were incapable of producing a BOLD response in these regions regardless of the tasks performed,such regionally decreased CVR is indicative of NVU.The low nCVR ratios indicate high prevalence of NVU in this LGG cohort,which is an important consideration in the interpretation of clinical presurgical mapping with functional magnetic resonance(MR)imaging.CONCLUSION:Our preliminary study shows that BH CVR mapping is clinically feasible and demonstrates an unexpectedly high prevalence of NVU in patients with LGG. | Jay J Pillai Domenico Zacá | 2011 | World Journal of Clinical Oncology2011，2，12： | 4 |
| 3 | Membrane-encapsulated controlled release urea fertilizers based on acrylamide copolymers 显示文摘 | Abrahamand J Rajasekharan Pillai V N | 1996 | Journal of Applied Polymer Science1996，60，： | 1 |
| 4 | A maintenance study of fishing vessel equipment using delay-time analysis显示文摘 | Pillay A Wang J Wall A D | 2001 | Journal of Quality in Maintenance Engineering2001，7，2： | 1 |
| 5 | Perioperative lateral tro- chanteric wall fractures:sliding hip screw versus percutaneous com- pression plate for intertrochanteric hip fractures 显示文摘 | Langford J Pillai G Ugliailoro AD | 2011 | Orthop Trauma2011，25，4： | 1 |
| 6 | 显示文摘 | Pillai S K Hamoudi S Belkacemi K J | 2013 | Appl Catal A-Gen2013，455，： | 1 |
| 7 | Genetic strueture and biogeography of Asian arowana (Scleropages formosus) determined by microsatellite and mitochondrial DNA analysis显示文摘 | TANG P Y SIVANANTHAN J PILLAY S O | 2004 | Asian Fisheries Scienee2004，17，： | 1 |
| 8 | Efficacy of anescherichia coli phytase in broilers fed adequate or reducedphosphorus diets and its effect on carcass characteristics显示文摘 | Pillai P B Owens C M Emmert J L | 2006 | Poult Sci2006，85，10： | 1 |
| 9 | The MLQ Revisited:Psychometric Properties and Recommendations显示文摘 | Tejeda M J Scandura T A Pillai R | 2001 | Leadership Quarterly2001，12，： | 1 |
| 10 | Ultraviolet radiation and skin aging:roles of reactive oxygen species,inflammation and protease activation,and strategies for prevention of inflammation-induced matrix degradation-a review显示文摘 | Pillai S Oresajo C Hayward J | 2005 | Int J Cosmet Sci2005，27，： | 1 |
| 11 | A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1显示文摘 | Pillay J Kamp V M van-Hoffen E | | 0，，01： | 1 |
| 12 | Influence of solution p H on the electron transport of the self-assembled nanoarrays of single-walled carbon nanotube-cobalt tetra-aminophthalocyanine on gold electrodes:Electrocatalytic detection of epinephrine显示文摘 | Ozoemena K I Nkosi D Pillay J | 2008 | Electrochimica Acta2008，53，6： | 1 |
| 13 | Poly (ADP-ribose) polymerase-1-deficient mice are protected from angiotensin Ⅱ-induced cardiac hypertrophy显示文摘 | PILLAI J B GUPTA M RAJAMOHAN S B | 2006 | Am J Physiol Heart Circ Physiol2006，291，： | 1 |
| 14 | Young’s modulus for laminated machine structures with particular reference to switched reluctance motor vibrations 显示文摘 | Tang Z J Pillay P Omekanda A M | 2004 | Transactions on Industry Applications2004，40，3： | 1 |
| 15 | Perioperative lateral tro- chanteric wall fractures: sliding hip screw versus percutaneous compression plate for intertrochanteric hip fractures 显示文摘 | Langford J Pillai G Ugliailoro A D | 2011 | J Orthop Trauma2011，25，4： | 1 |
| 16 | Modified Failure Mode and Effects Analysis Using Approximate Reasoning显示文摘 | Pillay A Wang J | 2003 | Reliability Engineering & System Safety2003，79，1： | 1 |
| 17 | “Supercharged”isoperistaltic coloninterposition for long-segment esophageal reconstruction显示文摘 | Kesler K A Pillai S T Birdas T J | 2013 | Ann Thorac Surg2013，95，4： | 1 |
| 18 | A risk ranking approach incorporating fuzzy set theory and grey theory显示文摘 | PILLAY A WANG J | 2003 | Engineering Reliability &System Safety2003，79，1： | 1 |
| 19 | Coronary artery surgery and extracor- poreal circulation: the search for a new standard 显示文摘 | Pillai J B Suri R M | 2008 | J Car- diothorac Vasc Anesth2008，22，4： | 1 |
| 20 | Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA显示文摘 | Leslie A Kavanagh D Honeyborne I Pfafferott K Edwards C Pillay T Hilton L Thobakgale C Ramduth D Draenert R Le Gall S Luzzi G Edwards A Brander C Sewell A K Moore S Mullins J Moore C Mallal S Bhardwaj N Yusim K Phillips R Klenerman P Korber B Kiepiela P Walker B Goulder P | 2005 | J Exp Med2005，201，6： | 1 |
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