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| 1 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 2 | Systematic review of cystic duct closure techniques in relation to prevention of bile duct leakage after laparoscopic cholecystectomy显示文摘AIM To study the effect of different techniques of cystic duct closure on bile leakage after laparoscopic cholecystectomy(LC) for biliary disease.METHODS A systematic search of MEDLINE, Cochrane and EMBASE was performed. Rate of cystic duct leakage(CDL) was the primary outcome. Risk of bias was evaluated. Odds ratios were analyzed for comparison of techniques and pooled event rates for non-comparative analyses. Pooled event rates were compared for each of included techniques.RESULTS Out of 1491 articles, 38 studies were included. A total of 47491 patients were included, of which 38683(81.5%)underwent cystic duct closure with non-locking(metal)clips. All studies were of low-moderate methodological quality. Only two studies reported separate data on uncomplicated and complicated gallbladder disease. For overall CDL, an odds ratio of 0.4(95%CI: 0.06-2.48)was found for harmonic energy vs clip closure and an odds ratio of 0.17(95%CI: 0.03-0.93) for locking vs non-locking clips. Pooled CDL rate was around 1% for harmonic energy and metal clips, and 0% for locking clips and ligatures. CONCLUSION Based on available evidence it is not possible to either recommend or discourage any of the techniques for cystic duct closure during LC with respects to CDL,although data point out a slight preference for locking clips and ligatures vs other techniques. No separate recommendation can be made for complicated gallbladder disease. | Aafke H van Dijk Stijn van Roessel Philip R de Reuver Djamila Boerma Marja A Boermeester Sandra C Donkervoort | 2018 | World Journal of Gastrointestinal Surgery2018，10，6： | 3 |
| 3 | Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial显示文摘 | S Vincent Rajkumar Susanna Jacobus Natalie S Callander Rafael Fonseca David H Vesole Michael E Williams Rafat Abonour David S Siegel Michael Katz Philip R Greipp | 2010 | Lancet Oncology2010，，1： | 2 |
| 4 | Competing risks survival analysis applied to data from the Australian Orthopaedic Association National Joint Replacement Registry显示文摘 | Marianne H G Philip R Stephen E G | 2010 | Acta Orthopaedica2010，8，5： | 1 |
| 5 | Maximum andminimum temperature trends for the globe显示文摘 | David R E Briony H Philip D J | 1997 | Science1997，277，5324： | 1 |
| 6 | Zinc oxide varistors-A review 显示文摘 | Levinson L M Philip H R | 1986 | Am Ceram Soc Bull1986，65，4： | 1 |
| 7 | The Marketing Audit Comes of Age显示文摘 | PHILIP K WILLIAM T G WILLIAM H R | 1997 | Sloan Management Review1997，18，2： | 1 |
| 8 | The effect of hydrogen peroxide on a CST under cesium ion exchange conditions显示文摘 | KIN S H PHILIP M ANTHONY R G | 2003 | Separation Science and Technology2003，38，1213： | 1 |
| 9 | Characterization of novel gene, wosA, regulating FlhDC expression in Proteus mlrabilis显示文摘 | Janet K H Philip N R | 2008 | Bacteri- ol2008，3，： | 1 |
| 10 | Drying and rewetting effects on soil microbial community composition and nutrient leaching显示文摘 | Gordon H Philip M H Bardgett R D | 2008 | Soil Biology & Biochemistry2008，40，： | 1 |
| 11 | Finite element forming simulation for non- crimp fabrics using a non- orthogonal constitutive equation 显示文摘 | Yu W R Philip H Andrew L | 2005 | Composites Part A2005，36，8： | 1 |
| 12 | The role of alanine in the acute response of Giardia intestinalis to hypo-osmot- ic shock显示文摘 | Jeong H Park Philip J Schofield Michael R Edwards | 1995 | Microbiology1995，141，： | 1 |
| 13 | Accurate analytical method for the extraction of solar cell model parameters显示文摘 | Phang J C J Chan D S H Philips J R | 1984 | Electronics Letters1984，20，10： | 1 |
| 14 | Application of PLS and back-propagation neural networks for the estimation of soil properties显示文摘 | ZIAD R PHILIP K H MARA J J | 2005 | Chemometrics and Intelligent Laboratory Systems2005，75，1： | 1 |
| 15 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and sep- tic shock:2008显示文摘 | Philip R D Carlet J M Masure H | 2008 | Intensive Care Med2008，34，： | 1 |
| 16 | Epigenomic plasticity enables human pancreatic [alpha] to [Beta] cell reprogramming显示文摘 | Bramswig Nuria C Everett Logan J Schug Jonathan Dorrell Craig Liu Chengyang Luo Yanping Streeter Philip R Naji Ali Grompe Markus Kaestner Klaus H | 2013 | Journal of Clinical Investigation2013，，3： | 1 |
| 17 | Development,Organisation and Implementation of a Surgical Skills‘Boot Camp’:SIMweek显示文摘 | Singh P Aggarwal R Philip H | 2015 | World JSurg2015，39，7： | 1 |
| 18 | Progress of Reha- bilitation for Cardiac Patients Depending on the Degree of Self-Sufficiency at Admission 显示文摘 | Marx R Philips H Bassenge D | 2016 | Rehabilitation (Stuttg)2016，55，1： | 1 |
| 19 | Osteopontin: it's role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression显示文摘 | Das R Philip S Mahabeleshwar G H | 2005 | IUB MB Life2005，57，6： | 1 |
| 20 | Analysis of CANLEX liquefaction embankments:prototype and centrifuge models显示文摘 | PUEBLA H BYRME P M PHILIPS R | 1997 | Canadian Geotechnical Journal1997，34，5： | 1 |
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