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| 1 | Can tranexamic acid change preoperative anemia management during total joint arthroplasty?显示文摘AIM: To investigate the postoperative transfusion and complication rates of anemic and nonanemic total joint arthroplasty patients given tranexamic acid(TXA).METHODS: A cross-sectional prospective study was conducted of primary hip and knee arthroplasty cases performed from 11/2012 to 6/2014. Exclusion criteria included revision arthroplasty, bilateral arthroplasty, acute arthroplasty after fracture, and contraindication to TXA. Patients were screened prior to surgery, with anemia was defined as hemoglobin of less than 12 g/d L for females and of less than 13 g/d L for males. Patients were divided into four different groups, based on the type of arthroplasty(total hip or total knee) and hemoglobin status(anemic or nonanemic). Intraoperatively, all patients received 2 g of intravenous TXA during surgery. Postoperatively, allogeneic blood transfusion(ABT) was directed by both clinical symptomsand relative hemoglobin change. Complications were recorded within the first two weeks after surgery and included thromboembolism, infection, and wound breakdown. The differences in transfusion and complication rates, as well as the relative hemoglobin change, were compared between anemic and nonanemic groups.RESULTS: A total of 232 patients undergoing primary joint arthroplasty were included in the study. For the total hip arthroplasty cohort, 21%(18/84) of patients presented with preoperative anemia. Two patients in the anemic group and two patients in the nonanemic group needed ABTs; this was not significantly different(P = 0.20). One patient in the anemic group presented with a deep venous thromboembolism while no patients in the nonanemic group had an acute complication; this was not significantly different(P = 0.21). For nonanemic patients, the average change in hemoglobin was 2.73 ± 1.17 g/d L. For anemic patients, the average change in hemoglobin was 2.28 ± 0.96 g/d L. Between the two groups, the hemoglobin difference of 0.45 g/d L was not significant(P = 0.13). For the total knee arthroplasty cohort, 18%(26/148) of patients presented with preoperative anemia. No patients in either group required a blood transfusion or had an acute postoperative complication. For nonanemic patients, the average change in hemoglobin was 1.85 ± 0.79 g/d L. For anemic patients, the average change in hemoglobin was 1.09 ± 0.58 g/d L. Between the two groups, the hemoglobin difference of 0.76 g/d L was significant(P < 0.001). CONCLUSION: TXA administration results in low transfusion and complication rates and may be a useful adjunct for TJA patients with preoperative anemia. | Duy L Phan Joseph B Rinehart Ran Schwarzkopf | 2015 | World Journal of Orthopedics2015，6，7： | 5 |
| 2 | Prostaglandins as endogenous mediators of interleukin production显示文摘 | Runkel S L Chensus S W Phan S H | 1985 | J Immunol1985，136，1： | 2 |
| 3 | Improved quarter-point crack tip element显示文摘 | GRAY L J PHAN A V PAULINO G H | 2003 | Engineering Fracture Mechanics2003，70，： | 1 |
| 4 | Milk-clotting enzymes pro- duced by culture of Bacillus su, btilis natto 显示文摘 | Shieh C H Phan Thi L A Shih I L | 2009 | Biochemical Engi- neering Journal2009，43，： | 1 |
| 5 | Functional neuroanatomy of e-motion:a meta-analysis of emotion activation studies in PET and Mf RI显示文摘 | Phan K L Wager T Taylor S F | 2002 | NeuroImage2002，16，2： | 1 |
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| 7 | Estimating intensity of atmospheric ice accretion on stationary structures显示文摘 | Makkonen L Phan L C | | 0，，10： | 1 |
| 8 | Biological variability of sperm DNA denaturation in infertile men显示文摘 | Zini A Kamal K Phan D et a l | 2001 | Urology2001，58，2： | 1 |
| 9 | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolide derived from tylosin 显示文摘 | Phan L T Jian T Chen Z | 2004 | J Med Chem2004，47，： | 1 |
| 10 | A Laplacian approach to multi-oriented text detection in video显示文摘 | Shivakumara P Phan T Q Tan C L | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，33，2： | 1 |
| 11 | Chemotactic factors and renal inflammation 显示文摘 | Rovin B H Phan L T | 1998 | Am J Kidney Dis1998，31，6： | 1 |
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| 13 | The influence of electro-freezing on ice for- mation on high-voltage DC transmission lines显示文摘 | Phan C L Laforte J L | 1981 | Cold Regions Science and Technology1981，4，1： | 1 |
| 14 | Switchable Solvents Con- sisting of Amidine/Alcohol or Guanidine/Alcohol Mixtures显示文摘 | L Phan D Chiu D J Heldebrant | 2008 | In- dustrial & Engineering Chemistry Research2008，47，3： | 1 |
| 15 | GPS muhipath mitiga-tion:a nonlinear regression approach 显示文摘 | Phan Q H Tan S L Ian McLoughlin | 2013 | GPS Solut2013，17，： | 1 |
| 16 | Review of mechanical properties of HSC at elevated temperature显示文摘 | PHAN L T CARINO N J | | 0，，01： | 1 |
| 17 | Milk-clotting enzymes produced by culture of Bacillus subtilis natto显示文摘 | SHIEH C J PHAN T L A SHIH I L | 2009 | Biochemical Engineering Journal2009，43，1： | 1 |
| 18 | Review of mechanical properties of HSC at elevated temperature 显示文摘 | Phan L T Carino N J | 1998 | Journal of Materials inCivil Engineering1998，10，1： | 1 |
| 19 | Algorithms for supporting disconnected write operations for wireless Web access in mobile client-server environments 显示文摘 | I R Chen N A Phan I L Yen | 2002 | IEEE Trans on Mobile Computing2002，1，1： | 1 |
| 20 | Evaluation of the production potential of bio-oil from Vietnamese biomass resources by fast pyrolysis 显示文摘 | Phan B M Q Duong L T Nguyen V D | 2014 | Biomass and Bioenergy2014，62，： | 1 |
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