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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017,9,36: | 6 |
| 2 | Probability-based protein identification by searching sequence databases using mass spectrometry data显示文摘 | Pappin D J Creasy D M | 1999 | Electrophoresis1999,,20: | 1 |
| 3 | Metastability in Near-surface Rocks of Minerals in the System Al2O3-SiO2-H2O显示文摘 | Anovitz L M Perkins D Essene E J | | 0,,39: | 1 |
| 4 | Controlled trial prednisolone in acute polyneuropathy显示文摘 | Hughes R A Newsom-Davis J M Perkin G D | 1978 | Lancet1978,2,: | 1 |
| 5 | Do grain boundaries affect microwave dielectric loss in oxides 显示文摘 | BREEZE J D PERKINS J M MCCOMB D W | 2009 | J Am Ceram Soe2009,92,3: | 1 |
| 6 | The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway 显示文摘 | Perkins D Pereira E F Gober M | 2002 | J Virol2002,76,3: | 1 |
| 7 | Catalysis at the metal-support interface exemplified by the photocatalytic reforming of methanol on Pd/TiO2显示文摘 | BOWKER M JAMES D STONE P BENNETT R PERKINS N MILLARD L GREAVES J DICKINSON A | 2003 | J Catal2003,217,2: | 1 |
| 8 | Macroelectronic applications of carbon nanotube networks 显示文摘 | Novak J P Lay M D Perkins F K | 2004 | Solid - State Ele2004,48,10: | 1 |
| 9 | The Daikon sys-tem for dynamic detection of likely invariants显示文摘 | Ernst M D Perkins J H Guo P J | 2007 | Scienceof Computer Programming2007,69,3: | 1 |
| 10 | Observation of brittledeformation features at the maximum stress of westerly granite and Solnhofen limestone显示文摘 | Friedman M Perkins R D Green S J | 1970 | International Journal of Rock Mechanics and Mining Sciences1970,7,3: | 1 |
| 11 | Empowerment theory, research, and application显示文摘 | Perkins D D Zimmerman M A | 1995 | Am J Community Psychol1995,23,5: | 1 |
| 12 | Do grain boundaries affect microwave dielectric loss in oxides 显示文摘 | Breeze J D Perkins J M MeComb D W Alford N M | 2009 | Journal of the American Ceramic Society2009,92,3: | 1 |
| 13 | Immuno contraceptive effects on female rabbits infected with recombi nant myxoma virus expressing rabbit ZP2 or ZP3 显示文摘 | Mackenzie S M Mclaughlin E A Perkins H D | 2006 | Biology of Reproduction2006,74,3: | 1 |
| 14 | Probability- based protein identification by searching sequence databases using mass spectrometry data显示文摘 | Perkins D N Pappin D J C Creasy D M | 1999 | Electrophoresis1999,20,: | 1 |
| 15 | Sterically engineered perylene dyes for high efficiency oriented fluorophore luminescent solar eoncentrators显示文摘 | Benjamin W E Veit D R Perkins M J | 2014 | Chemistry of Materials2014,26,3: | 1 |
| 16 | Paelitaxel-Induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration : Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment 显示文摘 | SYMMANS W F VOLM M D SHAPIRO R L PERKINS A B KIM A Y DEMARIA S YEE H T MCMULLEN H ORATZ R KLEIN P FORMENTI S C MUGGIA F | 2000 | Clin Cancer Res2000,6,12: | 1 |
| 17 | Emotional intelligence and giftedness显示文摘 | Mayer J D Perkins D M Caruso D R | 2001 | Roeper Review2001,23,3: | 1 |
| 18 | Controled trial of prednisolone in acute polyneuropathy显示文摘 | Hughes R A Newsow-Davis J M Perkin G D | 1978 | Lancet1978,2,253: | 1 |
| 19 | Spatial decision support systems: an overview of technology and a test of efficacy显示文摘 | Crossland M D Wynne B E Perkins W C | 1995 | Decision Support Systems1995,14,: | 1 |
| 20 | namies model for internal An efficient multi-body dycombustion engine systems 显示文摘 | Zheng D M Perkins N C | 2003 | Multi-body System Dynamics2003,10,: | 1 |