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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Sharp weighted estimates for multilinear commutators显示文摘 | PEREZ C TRUJILLO G R | 2002 | J London Math Soe2002，65，2： | 1 |
| 3 | Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects 显示文摘 | Xu WS Perez G Ngo L | 2005 | Cancer Res2005，65，： | 1 |
| 4 | Suppression of performance curve instability of an axial-flow pump by using a double-inlet-nozzle 显示文摘 | Perez Flores P Kosyna G Wulff D | 2008 | International Journal of Rotating Machinery2008，，53： | 1 |
| 5 | Rhesus rotavirus-based quadrivalent vaccine is efficacious despite age, socioeconomic conditions and seasonality in Venezuela显示文摘 | Eglee Perez M Glass R Alvarez G | 2000 | Vaccine2000，19，78： | 1 |
| 6 | Stability of the secondary antioxidant bis (2,4 - di - tert - butylphenyl) pentaerythritol diphosphite in food simulants 显示文摘 | Perez L C Rijk R Simal G J | 1998 | Journal of Agricultural and Food Chemistry1998，46，2： | 1 |
| 7 | Autoimmune thyroiddisease in primary Sjogren syndrome 显示文摘 | Perez B Kraus A Lopez G | 1995 | Am J Med1995，99，： | 1 |
| 8 | Biosynthesis of strawberry aroma compounds through amino acid metabolism显示文摘 | Perez A G Olias R Luaces P Sanz C | 2002 | Journal of Agricultural and Food Chemistry2002，50，14： | 1 |
| 9 | Dynamical behavior of the firings in a coupled neuronal system显示文摘 | Wang W Perez G Cerdeira H A | 1993 | Phys Rev E1993，47，： | 1 |
| 10 | Ozonolysis of cinnamic acid in water medium显示文摘 | Aguilar G Perez Rey R Baluja C | 2001 | Ozone: Science & Engineering2001，23，2： | 1 |
| 11 | Molecular determinants of the pathogenicity of H5N1 influenza viruses in chickens显示文摘 | Perez D R Webster R G | 2004 | International Congress Series2004，1263，： | 1 |
| 12 | Photoperiod modi es the diurnal expression proele of VvPHYA and VvPHYB transcripts in eld-grown grapevine leaves显示文摘 | KUHN N ORMENO-NUNEZ J JAQUE-ZAMORA G PEREZ F J | 2009 | Journal of Plant Physiology2009，166，： | 1 |
| 13 | Evolution of strawberry alcohol acyltransferase activity during fruit development and storage显示文摘 | PEREZ A G SANZ C OLIAS R | 1996 | J Agric Food Chem1996，44，10： | 1 |
| 14 | Vasoregulation by the betal subunit of the calcium-activated potassium channel显示文摘 | Brenner R Perez G J Bonev A D | 2000 | Nature2000，407，6806： | 1 |
| 15 | The many roles of the eukaryotic elongation factor 1 complex显示文摘 | Sasikumar A N Perez W B Kinzy T G | | 0，，04： | 1 |
| 16 | A new type of heteropolyoxometalates formed from lacunary polyoxotungstate ions and europium or yttrium cations显示文摘 | HOWELL R C PEREZ F G JAIN S | | 0，，： | 1 |
| 17 | As- sessing signatures of selection through variation in linkage disequilibrium between taurine and indicine cattle显示文摘 | Perez A M Utsunomiya Y T Meszaros G | 2014 | Genet Sel Evol2014，5，4： | 1 |
| 18 | TNF-αand IL-10 promoter polymorphisms,HPV infection,and cervical cancer risk显示文摘 | Barbisan G Perez LO Contreras A | 2012 | Tumour Biol2012，33，5： | 1 |
| 19 | Accurateand efficient modeling to calculate the voltage dependence ofliquid crystal based reflectarray cells 显示文摘 | PEREZ P G FLORENCIO R ENCINAR J A | 2014 | IEEE Transactions onAntennas and Propagation2014，62，2： | 1 |
| 20 | Laser nitriding of an intermetallic TiA1 alloy with a diode laser 显示文摘 | Perez M G Harlan N R Zapirain F | 2006 | Surface and Coatings Technology2006，200，17： | 1 |
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