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| 1 | Multiple primary colorectal cancer: Individual or familial predisposition?显示文摘Colorectal carcinoma(CRC) is one of the most frequent cancers. Along the surface of the large bowel, several foci of CRC may appear simultaneously or over the time. The development of at least two different tumours has been defined as multiple primary CRC(MPCRC):When more than one tumour is diagnosed at the same time, it is known as synchronous CRC(SCRC), while when a second neoplasm is diagnosed some time after the resection and/or diagnosis of the first lesion, it is called metachronous CRC(MCRC). Multiple issues can promote the development of MPCRC, ranging from different personal factors, such as environmental exposure, to familial predisposition due to hereditary factors. However, most studies do not distinguish this dichotomy. High- and low-pentrance genetic variants are involved in MPCRC. An increased risk for MPCRC has been described in Lynch syndrome, familial adenomatous polyposis, and serrated polyposis. Non-syndromic familial CRCs should also be considered as risk factors for MPCRC. Environmental factors can promote damage to colon mucosae that enable the concurrence of MPCRC. Epigenetics are thought to play a major role in the carcinogenesis of sporadic MPCRC. The methylation state of the DNA depends on multiple environmental factors(e.g., smoking and eating foods cooked at high temperatures), and this can contribute to increasing the MPCRC rate. Certain clinical features may also suggest individual predisposition for MPCRC. Different etiopathogenic factors are suspected to be involved in SCRC and MCRC, and different familial vs individual factors may be implicated. MCRC seems to follow a familial pattern, whereas individual factors are more important in SCRC. Further studies must be carried out to know the molecular basis of risks for MPCRC in order to modify, if necessary, its clinical management, especially from a preventive point of view. | José A Pajares José Perea | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 7 |
| 2 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 3 | Region filling and object removal by exemplar-based image inpainting 显示文摘 | CRIMINISI A PEREA P TOYAMA K | 2004 | IEEE Transactions on Image Processing2004，13，9： | 1 |
| 4 | Communication between astrocytes and neurons:a complex language显示文摘 | Perea G Araque A | 2002 | J Physiol(Paris)2002，96，34： | 1 |
| 5 | Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes显示文摘 | Perea G Araque A | 2005 | J Neurosci2005，25，9： | 1 |
| 6 | The Value of the Modified Early Warning Score and Biochemical Parame- ters as Predictors of Patient Outcome in Acute Medical Ad- mission:A Prospective Study显示文摘 | Perea Y S Ranasinghe P Adikare A M | 2011 | Acute Med2011，10，3： | 1 |
| 7 | White light emission from rare earth activated yttrium silicate nanocrystanine powders and thin films显示文摘 | Gonzalez-Ortega J A Tejeda E M Perea N | 2005 | Optical Materials2005，27，7： | 1 |
| 8 | Primary adenoid cystic carcinoma of esophagus显示文摘 | Perea Guerrero H Frisancho Velarde O Palomino Portilla A | 2008 | Rev Gastroenterol Peru2008，28，1： | 1 |
| 9 | Continuous hydrolysis of whey proteins in a membrane recycle reactor 显示文摘 | Perea A Ugalde U | 1996 | Enzyme Microbiology and Technology1996，18，： | 1 |
| 10 | Comparison of high performance liquid chromatographic and microbiologic methods for the determination of voriconazole levels in plasma显示文摘 | PEREA S PENNICK GJ MODAK A | 2000 | Antimicrob Agents Chemother2000，44，5： | 1 |
| 11 | Comparison of diagnostic techniques for porcine proliferative enteropathy (Lawsonia intracellularis infection)显示文摘 | Huerta B Arenas A Carrasco L Maldonado A Tarradas C Carbonero A Perea A | 2003 | J Comp Pathol2003，129，23： | 1 |
| 12 | A game theoretic framework for the robust railway transit network designproblem 显示文摘 | LAPORTE G MESA J A PEREA F | 2010 | Transportation Research Part B: Methodological2010，44，4： | 1 |
| 13 | Comparison of high-performance liquid chromatographic and microbiological methods for determination of voriconazole levels in plasma显示文摘 | Perea S Pennick G J Modak A | 2004 | Antimicrob Agents Chemother2004，44，5： | 1 |
| 14 | Stochastic dominance equilibria in two-person noncooperative games 显示文摘 | Perea A Peters H Schulteis T Vermeulen D | 2006 | International Journal of Game Theory2006，34，4： | 1 |
| 15 | Continuous hydrolysis of whey proteins in a membrane recycle reactor 显示文摘 | Perea A Uglade U | 1996 | Enzyme Microbial Tech1996，18，： | 1 |
| 16 | Comparison of hi- gh-performance liquid chromatographic and microbiologi- cal methods for determination of voriconazole levels in plasma显示文摘 | Perea S Pennick G J Modak A | 2000 | Antimicrob Agents Chemother2000，44，5： | 1 |
| 17 | Molecular subgroups of small (pTl) breast carcinomas belonging exclusively to the ductal infiltrating variety 显示文摘 | SCHNEIDER J TEJERINA A PEREA C | 2007 | Cancer Genomics Proteomics2007，4，6： | 1 |
| 18 | Group B streptococcus and premature rupture of membranes and preterrn delivery显示文摘 | Matorras R Garcia Perea A Omenaca F | 1989 | Gynecol Obstet Invest1989，27，1： | 1 |
| 19 | In vitro interaction of caspofungin acetate with voriconazole against clinical isolates of Aspergillus spp显示文摘 | Perea S Gonzalez G Fothergill A W | 2002 | Antimicrob Agents Chemother2002，46，9： | 1 |
| 20 | The value of the modified early warning score and biochemicat parameters as predictors of patient outcome in acute medical admissluns a prospective study显示文摘 | Perea Y S Ranasinghe P Adikari A M | 2011 | Acute med2011，10，3： | 1 |
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