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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Rational syntheses, characterization, crystal structure, and replacement reactions of coordinated water molecules of ^10- (M =Cd, Co, Cu, Fe, Mn, Ni or Zn) 显示文摘 | Bi L H Huang R D Peng J | 2001 | J Chem Soc Dalton Trans2001，，： | 1 |
| 3 | Reaction of N-methyl-2-pyrrolidinone with carbon disulfide显示文摘 | Zong Z M Peng Y L Qin Z H | 2000 | Energy Fuels2000，14，3： | 1 |
| 4 | Experimental study on burning rates of square/rectangular gasoline and methanol pool fires under longitudinal air flow in a wind tunnel显示文摘 | HU L H LIU S PENG W | 2009 | Journal of Hazardous Materials2009，169，： | 1 |
| 5 | Synthesis and characterization of substitutional and interstitial nitrogen-doped titanium dioxides with visible light photocatalytic activity显示文摘 | Peng F Cai L Yu H | 2008 | J Solid State Chem2008，181，4： | 1 |
| 6 | An Optimization Method Inspired by Chaotic Ant Behavior 显示文摘 | LI L X YANG Y X PENG H P | 2006 | Internation- al Journal of Bifurcation Chaos2006，，16： | 1 |
| 7 | Molecular analysis of cellulose biosynthesis in Arabidopsis显示文摘 | ARIOLI T PENG L BETZNER A S BURN J WITTKE W HERTH W CAMILLERI C H(O)FTE H PLAZINSKI J BIRCH R CORKA GLOVER J REDMOND J WILLIAMSDN R E | 1998 | Science1998，279，： | 1 |
| 8 | HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced 'inside-out' signaling to extracellular matrix by preventing RhoA activation 显示文摘 | Xu H Zeng L Peng H | 2006 | Am J Physiol Renal Physiol2006，291，11： | 1 |
| 9 | Photoalignment of liquid crys- tals by cinnamate polyelectrolyte layer-by-layer ultrathin film 显示文摘 | Zhang L L Peng Z H Yao L S | 2007 | Appl Surf Sci2007，253，7： | 1 |
| 10 | Self-assembled star-shaped chlorin-core poly (6-caprolaetone) -poly ( ethyleneglycol ) diblock copolymer micelles for dual ehemo-photodynamic therapies 显示文摘 | Peng C L Shieh M J Tsai M H | 2008 | Biomaterials2008，29，26： | 1 |
| 11 | Temperature- and duration- dependent rice straw-derived biochar: Characteristics and its effects on soil properties of an UltisoI in southern China显示文摘 | PENG X YE L L WANG C H | 2011 | Soil & Tillage Research2011，112，： | 1 |
| 12 | Increased expression of the col agen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis显示文摘 | Glasson S Xu L Peng H | | 0，，08： | 1 |
| 13 | The prevalence of parasites and pathogens in Asian honeybees Apis cerana in China显示文摘 | Li J L Qin H R Wu J Sadd B M Wang X Evans J D Peng W Chen Y | 2012 | PLoS One2012，7，47： | 1 |
| 14 | Effect of Fe3 04 addition on removal of ammonium by zeolite NaA 显示文摘 | LIU H B PENG S C SHU L | 2013 | Journal of Colloid and Interface Science2013，390，1： | 1 |
| 15 | Antioxidant activity of peptide fractions from whey protein hydrolysates as measured by electron spin resonance显示文摘 | Peng X Y Xiong Y L Kong B H | 2009 | Food Chemistry2009，113，： | 1 |
| 16 | Os AAP6 functions as an important regulator of grain protein content and nutritional quality in rice显示文摘 | Peng B Kong H L Li Y B | 2014 | Nature Communications2014，5，： | 1 |
| 17 | Heat transfer characteristics of refrigerant-based nanofluid flow boiling inside a horizontal smooth tube 显示文摘 | PENG H DING G L JIANG W T | 2009 | International Journal of Refrigeration2009，32，6： | 1 |
| 18 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 19 | A new approach to the functionalization of single-walled carbon nanotubes with both alkyl and carboxyl groups 显示文摘 | Peng H Q Alemany L B Margrave J L | 2003 | J Am Chem Soc2003，125，15： | 1 |
| 20 | Research on resources optimisation deployment model and al- gorithm for collaborative manufacturing process显示文摘 | Yao C F Zhang D H Peng W L | 2006 | International Journal of Production Research2006，44，16： | 1 |
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