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| 1 | Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders显示文摘Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been shown that prolonged activation of the glutamatergic system leads to nerve damage and cell death. Following release from the pre-synaptic neuron and synaptic transmission, glutamate is either taken up into the presynaptic neuron or neighbouring glia by transmembrane glutamate transporters. Excitatory amino acid transporter(EAAT) 1 and EAAT2 are Na+-dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most abundant glutamate transporters, their primary role is to modulate levels of glutamatergic excitability and prevent spill over of glutamate beyond the synapse. This role is facilitated through the binding and transportation of glutamate into astrocytes and microglia. The function of EAAT1 and EAAT2 is heavily regulated at the levels of gene expression, post-transcriptional splicing, glycosylation states and cell-surface trafficking of the protein. Both glutamatergic dysfunction and glial dysfunction have been proposed to be involved in psychiatric disorder. This review will present an overview of the roles that EAAT1 and EAAT2 play in modulating glutamatergic activity in the human brain, and mount an argument that these two transporters could be involved in the aetiologies of schizophrenia and affective disorders as well as represent potential drug targets for novel therapies for those disorders. | Georgia M Parkin Madhara Udawela Andrew Gibbons Brian Dean | 2018 | World Journal of Psychiatry2018，8，2： | 9 |
| 2 | Global cancer statistics, 2002 显示文摘 | Parkin D M Bray F Ferlay J | 2005 | CA Cancer J Clin2005，55，2： | 1 |
| 3 | Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription - PCR ( qRT - PCR) 显示文摘 | Kroh EM Parkin RK Mitchell PS Tewari M | | Methods0，50，： | 1 |
| 4 | Estimating the world cancer burden:Globocan 200l显示文摘 | Parkin D M Bray F Ferlay J | 2001 | Int J Cancer2001，94，： | 1 |
| 5 | Global cancer statistics in the year 2000 显示文摘 | Parkin D M | 2001 | Lan- cet Oncol2001，2，9： | 1 |
| 6 | Estimating the world cancer burden:globocan 2000显示文摘 | Parkin D M Bray F Ferlay J | 2001 | Int J Cancer2001，94，： | 1 |
| 7 | Acoustic based condition monitoring of a diesel engine using self-organising map networks显示文摘 | Weidong Li Robert M Parkin Joanne Coy | 2002 | Applied Acoustics2002，，63： | 1 |
| 8 | Global cancer statistics, 2002显示文摘 | Parkin D M Bray F Ferlay J | 2005 | CA Cancer J Clin2005，55，2： | 1 |
| 9 | Global cancer statistics, 2002 显示文摘 | PARKIN D M BRAY F FERLAY J | 2005 | CA - A Cancer Journal for Clinicians2005，55，2： | 1 |
| 10 | Global cancer statistics,2002显示文摘 | PARKIN D M BRAY F FERLAY J | 2005 | CA Cancer J Clin2005，5，2： | 1 |
| 11 | Global cancer statis- tics, 2002显示文摘 | Parkin D M Bray F Ferlay J | 2005 | CA Cancer J Clin2005，55，2： | 1 |
| 12 | Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy显示文摘 | Cemazar M Parkins C S Holder A L | 2001 | Br J Cancer2001，84，4： | 1 |
| 13 | Estimates of the worldwide incidence of 25 major cancers in 1990 显示文摘 | Parkin D M Pisani P Ferlay J | 1999 | Int J Cancer1999，80，6： | 1 |
| 14 | Cancer burden in the year2000:The global picture显示文摘 | Parkin D M Bray F I Devesa S S | 2001 | Eur J Cancer2001，37，8： | 1 |
| 15 | Global cancer sta-tistics ,2002 显示文摘 | Parkin D M Bray F Ferlay J | 2005 | Ca Cancer J Clin2005，55，2： | 1 |
| 16 | Detection of ketamine and its metabolites in urine by ultra high pressure liquid chromatography-tandem mass spectrometry显示文摘 | PARKIN C M TURFUS C S SMITH W N | 2008 | Journal of Chromatography B2008，876，1： | 1 |
| 17 | Global cancer statistics,2002显示文摘 | PARKIN D M BRAG F FERLAY J | 2005 | CA Cancer J Clin2005，55，2： | 1 |
| 18 | Global cancer statistics显示文摘 | Parkin D M Bray F B Pisani P | 2005 | CA Cancer J Clin2005，55，2： | 1 |
| 19 | Bringing home the bacon: industry, employment, and income in bo- real Canada 显示文摘 | PATRIQUIN M N PARKINS J R STEDMAN R C | 2009 | The Forest Chronicle2009，85，1： | 1 |
| 20 | Global cancer statistics 显示文摘 | Parkin D M Bray F B Pisani P | 2005 | CA CancerJ Clin2005，55，2： | 1 |
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