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| 1 | Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma显示文摘AIM: To assess serum cartilage oligomeric matrix protein(COMP) as a marker of cirrhosis and risk of progression to hepatocellular carcinoma(HCC). METHODS: A COMP enzyme-linked immunosorbentassay was used to test 187 patients with chronic liver diseases at the time point of first evaluation. The selected patients included 72 with chronic hepatitis B infection, 75 with chronic hepatitis C infection, 22 with primary biliary cirrhosis, 7 with autoimmune hepatitis type 1, and 11 with alcoholic liver disease. Demographic, biochemical, histological and clinical characteristics of the patients were recorded at the first evaluation. One hundred and forty-seven patients were followed for a median [interquartile range(IQR)] duration of 96.5(102) mo. The clinical, biochemical and histological data, as well as the development of cirrhosis, HCC according to internationally accepted criteria and in case of death, a liver-related cause during the follow-up period, were recorded at the electronic database of our clinic. COMP determination was also performed in 43 healthy individuals who served as the control study group.RESULTS: COMP positivity(> 15 U/L) was detected in 22%-36% among chronic liver disease groups. Strikingly, almost 83% of COMP-positive patients were cirrhotic at baseline, independently of cause of liver disease. Among the patients who developed HCC during follow-up, 73.7%(14/19) were COMP positive at baseline. COMP positivity was significantly associated with older age(P < 0.001), advanced fibrosis(P = 0.001) and necroinflammatory activity(P = 0.001), higher aspartate aminotransferase(P < 0.001), alanine aminotransferase(P < 0.02), γ-glutamyl transpeptidase(P = 0.003), alkaline phosphatase(P = 0.001), bilirubin(P < 0.05), international normalized ratio(P = 0.002) and alpha-fetoprotein levels(P < 0.02), and lower albumin(P < 0.001), and platelet count(P = 0.008). COMP levels [median(IQR)] were significantly higher in cirrhotics compared to non-cirrhotics [13.8(7.9) U/L vs 9.8(4.6) U/L, respectively; P < 0.001]. On multivariate logistic regression analysis, COMP-positivity was independently associated only with cirrhosis(OR = 4.40, 95%CI: 1.33-14.69, P = 0.015). Kaplan-Meier analysis showed that COMP positivity was significantly associated with HCC development(P = 0.007) and higher incidence of liver-related death(P < 0.001). CONCLUSION: Elevated COMP levels are strongly associated with cirrhosis and HCC progression. Serum COMP is a new promising non-invasive biomarker for HCC risk assessment in surveillance programs. | Gary L Norman Nikolaos K Gatselis Zakera Shums Christos Liaskos Dimitrios P Bogdanos George K Koukoulis George N Dalekos | 2015 | World Journal of Hepatology2015，7，14： | 7 |
| 2 | Mechanical Behaviors of Ti-Si-N Coatings Deposited by Bias Sputtering显示文摘Ti-Si-N hard coatings were deposited on steel substrates by reactive unbalanced magnetron sputtering from Ti and Si elemental targets in a mixture of Ar and N2 gases.The influences of negative bias voltage(in the range of-30 to-80 V)on the mechanical properties of the coatings were investigated.In particular,the critical cycle during dynamic impact tests was employed to indicate the bonding strength of the coatings.It was found that the Ti-Si-N coatings prepared at lower constant bias voltages could effectively improve the adhesion and the cyclic impact performance,but their hardness was dropped significantly to 13 GPa at a bias of-30 V.Higher bias voltage values induced greater hardness.A maximum hardness of 47 GPa was obtained at a bias of-60 V.However,the coating adhesion was worse in this case,and the number of impact cycles(~8×10 3)that the coatings could endure was much shorter than that of TiN binary coatings(~2×104).On the other hand,the bias voltage was varied linearly from-40 to-60 V during Ti-Si-N deposition.Under this circumstance,the hardness of the coatings deposited with the bias-graded configuration remained very high(42 GPa),and the adhesion strength was improved substantially.Also,the critical impact cycle could reach as high as 1.8×104.Therefore,bias-graded deposition can provide an effective processing route to prepare Ti-Si-N superhard coatings with high adhesion strength and impact resistance. | P W Shum | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 3 | Feasibility Study of Using DLC Coating in Conjunction with Laser Ablation process to Improve the Tribological Performance of an Engineering Surface显示文摘Increasing demands such as low friction,low wear rate,and long life-time have reached the limits of single DLC coatings.In order to meet the requirements,we propose to use an integrated approach to improve the wear property of an engineering surface.Firstly,dimples are introduced perpendicular to an engineering surface by a Nd:YAG laser emitting at 1064 nm.Subsequently,solid lubricant DLC is prepared on the patterned surface by magnetron sputtering technique.The effect of dimple densities from 7%to 45 %on tribological properties of the coating surface was revealed.The wear performance of the textured DLC surfaces was studied by a pin-on-disk reciprocating sliding wear tester under boundary lubrication and dry conditions.The results showed that the DLC coatings with appropriate dimple densities have an obvious improvement on wear performance in term of friction coefficient,wear rate and wear life,as compared to un-textured DLC coatings.In boundary lubrication conditions,the improved wear performance can be explained by the promotion of reservoirs to enhance lubricant retention during sliding.In dry condition,the dimples trap wear particles and leave a free interface between pin and sliding contact surface,and avoid the surface worn by abrasive manner,thereby improving the wear performance of the DLC coating. | Shum P W | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 4 | E-subvarieties of the variety of idempotent semirings显示文摘 | Zhao X Z Shum K P Guo Y Q | 2001 | Algebra Universalis2001，46，： | 1 |
| 5 | Strong resonance and a highly compact long period grating in a large-mode-area photonic crystal fiber 显示文摘 | Zhu Y N Shum P Chong H J | 2003 | Optics Express2003，11，16： | 1 |
| 6 | Weakly c-normal subgroups of finite groups and their properties显示文摘 | Zhu L J Guo W B Shum K P | 2002 | Comm Alg2002，30，11： | 1 |
| 7 | Improvement of high-speed turning performance of TiA1N coatings by using a pretreatment of high-energy ion implantation 显示文摘 | Shum P W Li K Y Shen Y G | 2005 | Surface and Coating Technology2005，198，3： | 1 |
| 8 | Conditionally permutable subgroups and supersolubility of finite groups显示文摘 | GUO W SHUM K P SKIBA A | 2005 | Southeast Asian Bulletin of Mathematics2005，29，2： | 1 |
| 9 | Bandwidth tunable filter and spacing tunable comb filter with chirped-fiber Bragg gratings显示文摘 | DONG X SHUM P YANG X | 2006 | Opt Commun2006，29，2： | 1 |
| 10 | On Nilpotency of Finite Groups with Some Subgroups Supplemented 显示文摘 | Guo X Shum K P | 2003 | Algebra Colloquium2003，10，3： | 1 |
| 11 | X - permutable maximal subgroup s of Sylow subgroups of finite groups 显示文摘 | Guo Wenbin Shum K P Skiba A N | 2006 | Ukrain Matem J2006，58，10： | 1 |
| 12 | Quasi-C-Ehresmann semigroups and their subclasses显示文摘 | Gang Li Y Q Guo K P Shum | 2005 | Semigroup Forum2005，70，： | 1 |
| 13 | On left C-wrpp semigroups显示文摘 | Lan Du Shum K P | 2003 | Semigroup Form2003，67，3： | 1 |
| 14 | Completion of codes with finite bi-decoding delays显示文摘 | Zhang L Shum K P Peng S L | 2003 | Theoretical Computer Science2003，306，： | 1 |
| 15 | A class of idempotent semirings,semirings显示文摘 | SEN M K GUO Y Q SHUM K P | 2000 | Semigroup Forum2000，60，： | 1 |
| 16 | Weakly c-normal subgroups of finite groups and their properties 显示文摘 | Guo W B Shum K P | 2002 | Comm in Algebra2002，30，11： | 1 |
| 17 | semipermutable subgroups of finite group 显示文摘 | Guo Wenbin Shum K P Skiba A N | 2007 | J Algebra2007，315，1： | 1 |
| 18 | (D)-subvariety of idempotent semirings显示文摘 | ZHAO X Z GUO Y Q SHUM K P | 2002 | Algebra Colloquium2002，9，1： | 1 |
| 19 | On left C-Ehresmann cyber groups显示文摘 | Gang Li K P Shum | 2005 | Advances in Algebra and Analysis2005，1，： | 1 |
| 20 | Perfect rpp semigroups 显示文摘 | Guo X J Shum K P Guo Y Q | 2001 | Communications in Algebra2001，29，6： | 1 |
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