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| 1 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 2 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 3 | 澳大利亚MSA体系:通过食用品质评价牛肉品质显示文摘<正>澳大利亚肉类标准(MSA)是一个质量管理体系,旨在为消费者提供牛肉食用品质的准确描述。MSA分级系统中,消费者品尝的感官效果被用来描述牛肉的可口性。简单来讲,未经培训的消费者采用0~100直线标度的方法对牛肉样品的嫩度、多汁性、风味和总体接受度进行测试打分,包括下列语言叙述:不满意等级(无评分级)、普通级(或3星级)、良好级(或4星级)、优级(或5星级)。然后对4个感官指标通过权重换算。 | Pethick D W olkinghorne R P Thompson J M 吴鑫 | 2015 | 中国畜牧杂志2015，51，S1： | 2 |
| 4 | Dietary calcium and dairy products accelerate weight and fat loss during energy restriction in obese adults显示文摘 | ZEMEL M B THOMPSON W ZEMEL P | 2002 | Am J Clin Nutr2002，75，： | 2 |
| 5 | Selective detection of aroma compontents by acoustic wave sensors coated with conducting polymers films显示文摘 | Deng Z P Stone D C Thompson M | | Analyst0，121，： | 2 |
| 6 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 7 | Kinetics of the development of a nonehromate conversion coating for magnesium alloys and magnesium based metal matrix composites显示文摘 | Gonzalez-Nunez M A Lkeldon P Thompson G E | 1999 | Corrosion1999，55，12： | 1 |
| 8 | Fluctuating resources in plant communities: a general theory of invisibility显示文摘 | Davis M A Grime J P Thompson K | 2000 | Journal of Ecology2000，88，： | 1 |
| 9 | The Computer-Aided Design of Modular Fixturing Systems 显示文摘 | Grippo P M Gandhi M V Thompson B S | 1987 | The Int J ofAdv ManufTechnology1987，2，2： | 1 |
| 10 | Nutrient and microbial dynamics in high-intensity, zero-exchange shrimp ponds in Belize显示文摘 | Burford M A Thompson P J Mclntosh R P | 2003 | Aquaculture2003，219，14： | 1 |
| 11 | Proposed failure mechanism in a discontinuously reinforced aluminum alloy 显示文摘 | You C P Thompson A W Bernstein I M | 1987 | Scripta Metall1987，21，： | 1 |
| 12 | Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast Cancer progression 显示文摘 | Thompson M E Jensen R A Obermiller P S | 1995 | Nat Genet1995，9，4： | 1 |
| 13 | Global cycles of relative changes of sea level显示文摘 | VAIL P R MITCHUM R M THOMPSON S | 1977 | Am Ass Petrol Geol1977，26，： | 1 |
| 14 | Solvent effects on copper nano-particle, growth behavior in AOT reverse micelle 显示文摘 | CASON J P MILLER M E THOMPSON J B | 2001 | Physchem: B2001，105，12： | 1 |
| 15 | En hanced biotransformation of TCE using plant terpenoid in contaminated groundwater显示文摘 | BROWN J R M THOMPSON I P PATON G I | 2009 | Applied Microbiology2009，49，6： | 1 |
| 16 | The contribution of flocculated material to shrimp (Litopenaeus vannamei) nutrition in a highintensity zeroexchange system显示文摘 | Burford M Thompson P J McIntosh R P | 2004 | Aquaculture2004，232，1： | 1 |
| 17 | Direct mapping of hippocampal surfaces with intrinsic shape context显示文摘 | Shi Y G Thompson P M de Zubicaray G I | | 0，，03： | 1 |
| 18 | The use of high resolution magnetic resonance imaging in the prenatal diagnosis of fetal nuchaltumors 显示文摘 | Knox E M Muamar B Thompson P J | 2005 | Ultrasound Obstet Gyneco12005，26，6： | 1 |
| 19 | Ingestion of amniotic fluid enhances opiate analgesia in rats显示文摘 | KRISTAL M B THOMPSON A C ABBOTT P | 1986 | Physiology&behavior1986，38，： | 1 |
| 20 | Specification-Based Prototyping for Embedded Systems显示文摘 | Mats P E Heimdahl Steven p Miller | 1999 | Software Eng Notes1999，24，6： | 1 |
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