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| 1 | Helicobacter pylori infection and extragastric disorders in children: A critical update显示文摘Helicobacter pylori(H. pylori) is a highly prevalent, serious and chronic infection that has been associated causally with a diverse spectrum of extragastric disorders including iron deficiency anemia, chronic idiopathic thrombocytopenic purpura, growth retardation, and diabetes mellitus. The inverse relation of H. pylori prevalence and the increase in allergies, as reported from epidemiological studies, has stimulated research for elucidating potential underlying pathophysiological mechanisms. Although H. pylori is most frequently acquired during childhood in both developed and developing countries, clinicians are less familiar with the pediatric literature in the field. A better understanding of the H. pylori disease spectrum in childhood should lead to clearer recommendations about testing for and treating H. pylori infection in children who are more likely to develop clinical sequelae. A further clinical challenge is whether the progressive decrease of H. pylori in thelast decades, abetted by modern clinical practices, may have other health consequences. | Lucia Pacifico John F Osborn Valeria Tromba Sara Romaggioli Stefano Bascetta Claudio Chiesa | 2014 | World Journal of Gastroenterology2014，20，6： | 18 |
| 2 | Consequences of Helicobacter pylori infection in children显示文摘Although evidence is emerging that the prevalence of Helicobacter pylori (H. pylori) is declining in all age groups, the understanding of its disease spectrum continues to evolve. If untreated, H. pylori infection is lifelong. Although H. pylori typically colonizes the hu-man stomach for many decades without adverse con-sequences, children infected with H. pylori can manifest gastrointestinal diseases. Controversy persists regarding testing (and treating) for H. pylori infection in children with recurrent abdominal pain, chronic idiopathic thrombocytopenia, and poor growth. There is evidence of the role of H. pylori in childhood iron deficiency anemia, but the results are not conclusive. The possibility of an inverse relationship between H. pylori and gastroesophageal reflux disease, as well as childhood asthma, remains a controversial question. A better understanding of the H. pylori disease spectrum in childhood should lead to clearer recommendations about testing for and treating H. pylori infection in children who are more likely to develop clinical sequelae. | Lucia Pacifico Caterina Anania John F Osborn Flavia Ferraro Claudio Chiesa | 2010 | World Journal of Gastroenterology2010，16，41： | 11 |
| 3 | Hydroxyapatite ceramic as a bone substitute 显示文摘 | HEISE U OSBORN J DUWE F | 1990 | Int Orthop1990，14，： | 1 |
| 4 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 5 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 6 | Sterol regulatory element-binding proteins (SREBPs):key regulators of nutritional homeostasis and insulin action显示文摘 | Osborne T F | 2000 | J Biol Chem2000，275，32： | 1 |
| 7 | SREBPs: metabolic integrators in physiology and metabolism 显示文摘 | Jeon T I Osborne T F | 2012 | Trends Endocrin Met2012，23，2： | 1 |
| 8 | Brownian motion in the stock market显示文摘 | Osborne M F M | 1959 | Operations Research1959，7，2： | 1 |
| 9 | Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women:a prospective combined analysis of two multicenter trials显示文摘 | ROBERTSON J F OSBORNE C K HOWELL A | | 0，，02： | 1 |
| 10 | Beyond constructivism显示文摘 | Osborne J F | 1996 | Science Education1996，，1： | 1 |
| 11 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 12 | The development of the bradykinin agonist labradimil as a means to increase the permeabil?ity of the blood -brain barrier: from concept to cinical evalucation显示文摘 | Emerich D F Dean RL Osborn C | 2001 | Clin Pharmacokinet2001，40，2： | 1 |
| 13 | A digital watermark显示文摘 | Van Schyndel R G Tirkel A Z Osborne C F | 1994 | IEEE Int Conf on Image Processing1994，，2： | 1 |
| 14 | Determination of5-log pathogen reduction times for heat-processed,acidified vegetable brines显示文摘 | Breidt F Hayes JS Osborne JA | 2005 | Journal of Food Protection2005，68，2： | 1 |
| 15 | Fixation of Hip Prostheses by Hydroxyapatite Ceramic Coatings显示文摘 | FURLONG R J OSBORN J F | 1991 | J Bone Joint Surg1991，73，： | 1 |
| 16 | Laser-induced sign reversal of the nonlinear refractive index of Ag nanoclusters in soda-limeglass显示文摘 | OSBORNE D H HAGLUND R F GONELLA F | 1998 | Appl Phys B Lasers Opt1998，66，4： | 1 |
| 17 | Identification and validation of colorectal neoplasia - specific methylation markers for accurate classification of disease 显示文摘 | MODEL F OSBORN N AHLQUIST D | 2007 | Mol Cancer Res2007，5，2： | 1 |
| 18 | Does marital conflict cause child maladjustment? Directions and challenges for longitudinal re- search 显示文摘 | Fincham F D Grych J H Osborne L N | 1994 | Journal of Family Psychology1994，8，2： | 1 |
| 19 | A digital watermark显示文摘 | SCHYNDEL R G TIRKEL A Z OSBORNE C F | 1994 | Proceedings of IEEE international conference of image processing Austin Texas1994，2，： | 1 |
| 20 | Structural basis of filamin A functions显示文摘 | Nakamura F Osborn TM Hartemink CA | 2007 | Cell Biol2007，179，5： | 1 |
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