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| 1 | Impacts of common factors of life style on serum liver enzymes显示文摘AIM: To investigate the impacts of gender, age and factors of life style(alcohol, overweight, coffee and smoking) on serum liver enzymes.METHODS: Serum alanine aminotransferase(ALT) and gamma-glutamyltransferase(GGT) were measured from 6269 apparently healthy individuals(2851 men, 3418 women, mean age 45 ± 12 years, range 25-74 years) in a national cross-sectional health survey. All subjects underwent detailed clinical examinations and interviews including the amount and pattern of alcoholuse, coffee consumption and smoking habits. RESULTS: In this population with a mean ± SD alcohol consumption of 65 ± 105 g/wk and body mass index(BMI) of 26.1 ± 4.3 kg/m2, both ALT and GGT were significantly influenced by alcohol use(P < 0.001) and BMI(P < 0.001), whereas smoking increased only GGT(P < 0.001). A significant effect of age on ALT was seen in men(P < 0.001) whereas not in women. Significant two-factor interactions of alcohol use in men were observed with age(ALT: P < 0.01; GGT: P < 0.001) and BMI(GGT: P < 0.05). For ALT, a significant interaction also occurred between BMI and age(P < 0.005). In contrast, women showed significant interactions of alcohol use with BMI(GGT: P < 0.05), smoking(GGT: P < 0.001), and coffee consumption(GGT: P < 0.001). CONCLUSION: Life-style associated changes in liver enzymes may reflect health risks, which should be considered in the definition of normal limits for liver enzymes. | Joanna Danielsson Pivikki Kangastupa Tiina Laatikainen Mauri Aalto Onni Niemel | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-ahered expression 显示文摘 | Leucci E Onnis A Cocco M | 2010 | Int J Cancer2010，126，6： | 1 |
| 3 | Results of laser in situ keratomileusis in dif ferent degrees of myopia显示文摘 | Maldonado-Bas A Onnis R | 1998 | Ophthalmology1998，105，4： | 1 |
| 4 | Analysis of the fracture behaviour of a stitched single-lap joint 显示文摘 | AYMERICH F ONNIS R PRIOLO P | 2005 | Composites: Part A2005，36，： | 1 |
| 5 | Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase in- hibitors显示文摘 | Onnis V Congiu C Bjorklund E | 2010 | J Med Chem2010，53，5： | 1 |
| 6 | Non-invasive glucose measurement based on selective near in frared absorption: requirements on instrumentation and spectral range显示文摘 | Jussi Tenhunen Harri Kopola Onni Ahola | 1998 | Measurement1998，24，1： | 1 |
| 7 | MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogeneticmechanism involving miRNA deregulation 显示文摘 | Leucci E Cocco M Onnis A | 2008 | J Pathol2008，216，： | 1 |
| 8 | Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties 显示文摘 | Cocco MT Congiu C Onnis V | 2003 | Eur J Med Chem2003，38，5： | 1 |
| 9 | Cadmium and copper change root growth and morphology of Pinus pinca andPinus pinaster seedlings 显示文摘 | Arduini I Godbold DL Onnis A | 1994 | Physiol Plant1994，92，： | 1 |
| 10 | Production and detection theory of pulsed photoacoustic wave with maximum amplitude and minimum distortion in absorbing liquid显示文摘 | Zuomin Zhao Seppo Nissila Onni Ahola and Risto Myllyla | 1998 | IEEE1998，，： | 1 |
| 11 | Cadmium and copper change root growth and morphology of Pinus pinca and Pinus pinaster seedlings显示文摘 | Arduini I Godbold D L Onnis A | 1994 | Physiol Plant1994，92，： | 1 |
| 12 | MYC translocation-negative classical Burkitt lymphoma cases:an alternative pathogenetic mechanism involving miRNA deregulation显示文摘 | Leucci E Cocco M Onnis A | | 0，，04： | 1 |
| 13 | B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression显示文摘 | Leucci E Onnis A Cocco M | | 0，，06： | 1 |
| 14 | Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors显示文摘 | Onnis V Congiu C Bj(o)rklund E | 2010 | J Med Chem2010，53，5： | 1 |
| 15 | Development of HIF-1 inhibitors for cancer therapy显示文摘 | Onnis B Rapisarda A Melillo G | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 16 | Comparison of ^99mTc-ciprofloxacin,^99mTc-white blood cell and three phase bone imaging in the diagnosis of hip prosthesis infections:improved diagnostic accuracy with extended imaging time显示文摘 | Larikka M Ahonen A Onni N | 2002 | Nucl Med Commun2002，23，： | 1 |
| 17 | B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttran- scriptional level by miRNA-altered expression 显示文摘 | Leucci E Onnis A Cocco M | 2010 | Int J Cancer2010，126，6： | 1 |
| 18 | Alteration of microRNAs regulated by c-Myc in Burkitt lymphoma显示文摘 | Onnis A De Falco G Antonicelli G | 2010 | PLoS One2010，5，9： | 1 |
| 19 | Development of HIF-1 inhibitors for cancer therapy 显示文摘 | ONNIS B RAPISARDA A MELILLO G | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 20 | Pars interartieu- laris fenestration in the treatment of foraminal lumbar disc hemiation:a further surgical approach 显示文摘 | Di Lorenzo N Porta F Onnis G | 1998 | Neuro- surgery1998，42，1： | 1 |
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