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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Targeted therapies in gastric cancer and future perspectives显示文摘Advanced gastric cancer(AGC) is associated with a high mortality rate and, despite multiple new chemotherapy options, the survival rates of patients with AGC remains poor. After the discovery of targeted therapies, research has focused on the new treatment options for AGC. In the last two decades, many targeted molecules were developed against AGC. Currently, two targeted therapy molecules have been approved for patients with AGC. In 2010, trastuzumab was the first molecule shown to improve survival in patients with HER2-positive AGC as part of a first-line combination regimen. In 2014, ramucirumab was the second targeted molecule to improve survival rates and was suggested as treatment for patients with AGC who had progressed after firstline platinum plus fluoropyrimidine with or without anthracycline chemotherapy. Ramucirumab was the first targeted therapy acting as a single agent in patients with advanced gastroesophageal cancers. Although these two molecules were introduced into clinical use, many other promising molecules have been tested in phase Ⅰ-Ⅱ trials. It is obvious that in the near future many different targeted therapies will be in use for treatment of AGC. In this review, the current status of targeted therapies in the treatment of AGC and gastroesophageal junction tumors, including HER(2-3) inhibitors, epidermal growth factor receptor inhibitors, tyrosine kinase inhibitors, antiangiogenic agents, c-MET inhibitors, mammalian target of rapamycin inhibitors, agents against other molecular pathways fibroblast growth factor, Claudins, insulin-like growth factor, heat shock proteins, and immunotherapy, will be discussed. | Ozan Yazici M Ali Nahit Sendur Nuriye Ozdemir Sercan Aksoy | 2016 | World Journal of Gastroenterology2016，22，2： | 11 |
| 3 | Widespread deregulation of microRNA expression in human prostate cancer显示文摘 | Ozen M Creighton C J Ozdemir M Ittmann M | 2008 | Oncogene2008，27，12： | 1 |
| 4 | Transverse sinus air after cranial trauma显示文摘 | CIHANGIROGLU M OZDEMIR H KALENDER O | 2003 | Eur J Radiol2003，48，2： | 1 |
| 5 | Determination of the best nonlinear function in order to estimate growth in Morkaraman and Awassi lambs显示文摘 | Topal M Ozdemir M Aksakal V | | 0，，： | 1 |
| 6 | Primary primitive neuroectodermal tumor of the lumbar extradural space显示文摘 | Ozdemir N Usta G Minoglu M | 2008 | J Neurosurg Pediatri2008，2，3： | 1 |
| 7 | Comparison of the adsorption characteristics of azo-reaetive dyes on mezoporous minerals显示文摘 | Ozdemir O Armagan B Turan M | 2004 | Dyes Pigments2004，62，1： | 1 |
| 8 | Optimization of edible whey protein films containing preservatives for water vapor permeability,water solubility and sensory characteristics显示文摘 | Ozdemir M Floros J D | 2008 | Journal of Food Engineering2008，86，： | 1 |
| 9 | Effects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels aftor spinal cord trauma显示文摘 | Ozdemir M Cengiz SL Gurbilek M | 2005 | Mngnes Res2005，18，3： | 1 |
| 10 | Intravitreal triamcinolone acetonide for treatment of cystoid macular oedema in patients with retinitis pigmentosa显示文摘 | Ozdemir H Karacorlu M Karacorlu S | 2005 | Acta Ophthalmol Scand2005，83，2： | 1 |
| 11 | Intracranial hem- orrhage in children with congenital factor deficiencies显示文摘 | Patiroglu T Ozdemir M A Unal E | 2011 | Childs Nerv Syst2011，27，11： | 1 |
| 12 | Freeze-drying of pharmaceutical products: research and development needs 显示文摘 | Sadikoglu H Ozdemir M Seker M | 2006 | Drying Technology2006，24，7： | 1 |
| 13 | Synthesis and characterization of MCM-41 with different methods and adsorption of Sr2+ on MCM-41 显示文摘 | Yilmaz M S Ozdemir O D Piskin S | 2015 | Research on Chemical Intermediates2015，41，1： | 1 |
| 14 | Synthesis and Characterization of MCM-41 with Different Methods and Adsorption of Sr2+on MCM-41显示文摘 | Yilmaz M S Ozdemir O D Piskin S | 2015 | Research on Chemical Intermediates2015，41，1： | 1 |
| 15 | Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects 显示文摘 | OZATA M OZDEMIR I LICINIO J | 1999 | Journal of Clinical Endocrinology & Metabolism1999，84，10： | 1 |
| 16 | Inereased basic fibroblast growth factor levels in serum and blister fluid from patients with vitiligo显示文摘 | Ozdemir M Yillar G Wolf R | 2000 | Acta Derm Venereol2000，80，6： | 1 |
| 17 | Multidetector CT angiography of renal vasculature: normal anatomy and variants 显示文摘 | Turkvatan A Ozdemir M Cumhur T | 2009 | Eur Radiol2009，19，1： | 1 |
| 18 | An inflammatory verrueous epider- mal nevus concomitant with psoriasis: treatment with adalimumab显示文摘 | Ozdemir M Balevi A Esen H | 2012 | Dermatol Online J2012，18，10： | 1 |
| 19 | T regulatory cells and their counterparts:masters of immune regulation显示文摘 | Ozdemir C Akdis M Akdis CA | 2009 | Clin Exp Allergy2009，39，5： | 1 |
| 20 | Widespread deregulation of microRNA expression in human prostate cancer显示文摘 | Ozen M Creighton C J Ozdemir M Ittmann M | 2008 | Oncogene2008，27，： | 1 |
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