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| 1 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 2 | Myocardial insulin action and the contribution of in- sulin resistance to the pathogenesis of diabetic cardiomyopathy显示文摘 | Ouwens DM Diamant M | 2007 | Arch Phys- iol Biochem2007，113，2： | 1 |
| 3 | Role of PRAS40 in Akt and roTOR signaling in health and disease 显示文摘 | Wiza C Nascirnento EB Ouwens DM | 2012 | Am J Physiol Endocrinol Metab2012，302，12： | 1 |
| 4 | Integrated care programmes for chronically ill patients:a rev- iew of systematic reviews显示文摘 | Marielle Ouwens Hub Wollersheim Rosella Hermens | 2005 | International Journal for Quality in Health Care2005，17，2： | 1 |
| 5 | Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification显示文摘 | Ouwens DM Diamant M Fodor M | 2007 | Diabetologia2007，50，9： | 1 |
| 6 | Fractures of the base of the first meta- carpal bone: results of surgical treatment 显示文摘 | van Niekerk LM Ouwens R | 1989 | Injury1989，20，： | 1 |
| 7 | Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome 显示文摘 | Ouwens DM Bekaert M Lapauw B | 2012 | Arch Physiol Biochem2012，118，3： | 1 |
| 8 | Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves显示文摘 | Guyot P Ades AE Ouwens MJ | 2012 | BMC Med Res Methodul2012，12，： | 1 |
| 9 | Cost-effectiveness of routine varicella vaccination using the measles, mumps, rubella and varicella vaccine in France: an economic analysis based on a dynamic transmission model for varicella and herpes roster 显示文摘 | Littlewood KJ Ouwens MJ Sauboin C | 2015 | Clin Ther2015，37，4： | 1 |
| 10 | Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase显示文摘 | Kessler A Uphues I Ouwens D M | 2001 | AmJ Physiol Endocrinol Metab2001，280，1： | 1 |
| 11 | Hyperosmotic stress activates the insulin receptor in CHO cells 显示文摘 | Ouwens DM Gomes de Mesquita DS Dekker J | 2001 | Biochim Biophys Acta2001，1540，2： | 1 |
| 12 | Neurosyphilis in the mixed urban-rural community of the Netherlands 显示文摘 | Daey Ouwens IM Koedijk FD Fiolet AT | 2014 | Acta Neuropsychiatr2014，26，3： | 1 |
| 13 | Diversity in dia- betes care programmes and views on high quality diabetes care: are we in need of a standardized framework? 显示文摘 | Borgermans LA Goderis G Ouwens M | 2008 | Int J Integr Care2008，8，： | 1 |
| 14 | Hydrogen micro- structure in hydrogenated amorphous silicon 显示文摘 | OUWENS J D SCHROPP R E I | 1996 | Physical Review: B1996，54，24： | 1 |
| 15 | Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity显示文摘 | Bazuine M Ouwens D M Gomes de Mesquita D S | 2003 | Eur J Biochem2003，270，19： | 1 |
| 16 | Combined gene and protein expression of hormone-sensitivelipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese men显示文摘 | De Naeyer H Ouwens D M Van Nieuwenhove Y | 2011 | Obes Facts2011，4，5： | 1 |
| 17 | Implementation of integrated care for patients with cancer: a systematic review ofinterventions and effects显示文摘 | Ouwens M Hulscher M Hcrmens R | 2009 | Int J Qual Health Care2009，21，2： | 1 |
| 18 | Cardiaccontractile dysfunction in insulin-resistant rats fed ahigh-fat diet is associated with elevated CD36-mediatedfatty acid uptake and esterification显示文摘 | Ouwens DM Diamant M Fodor M | 2007 | Diabetologia2007，50，9： | 1 |
| 19 | Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats显示文摘 | Ouwens DM Boer C Fodor M de Galan P | 2005 | Diabetologia2005，48，6： | 1 |
| 20 | Myocardial insulin action and the contribution of insulin resistance to the pathogenesis of diabetic cardiomyopathy 显示文摘 | Ouwens DM Diamant M | 2007 | Arch PhysiolBiochem2007，113，2： | 1 |
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