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| 1 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 2 | Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits. | Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet | 2023 | aBIOTECH2023，4，2： | 2 |
| 3 | Head and neck injuries in fatal motorcycle collisions as determined by detailed autopsy显示文摘 | Ouellet JV Smith TA | 2002 | Annu Proc Assoc Adv Automot Med2002，46，： | 1 |
| 4 | Joint factoranalysis versus eigenchannels in speaker recognition显示文摘 | Kenny P Boulianne G Ouellet P | 2007 | IEEE Transactions on Audio Speech and LanguageProcessing2007，15，4： | 1 |
| 5 | Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice显示文摘 | Bergeron Y Ouellet N Deslauriers AM | 1998 | Infect Immun1998，66，3： | 1 |
| 6 | Novel carboxyl-amine bonding methods for poly(dimethylsiloxane)-based devices 显示文摘 | Ouellet E Yang C W T Lin T | 2010 | Langmuir2010，26，11： | 1 |
| 7 | Molecular characterization of two plant BI-1 homologues which suppress Bax-induced apoptosis in human 293 cells显示文摘 | Bolduc N Ouellet M Pitre F | 2003 | Planta2003，216，： | 1 |
| 8 | Regulation of a wheat actin-depolymerizing factor during cold acclimation显示文摘 | Ouellet F Carpentier E Cope M G | 2001 | Plant Physiol2001，125，： | 1 |
| 9 | Simultaneous percutaneous right portal vein embolization and left liver tumor radiofrequency ablation prior to a major right hepatic resection for bilateral colorectal metastases 显示文摘 | Elias D Santoro R Ouellet JF | 2004 | Hepatogastroenterology2004，51，60： | 1 |
| 10 | mucosal T cells regulate paneth and intermediate cell numbers in the small intestine of T spiralis infected mice 显示文摘 | Kamal M Wakelin D Ouellete AJ | 2001 | Clin Exp Immunol2001，126，1： | 1 |
| 11 | Joint factor analysis versus eigenehannels in speaker recognition 显示文摘 | Kenny P Boulianne G Ouellet P | 2007 | IEEE Trans Audio Speech Lang Process2007，15，4： | 1 |
| 12 | Population pharmacokinetics of gabapentin in infants and children显示文摘 | Bockbrader HN Wesche DL Shapiro DY Garofalo E | 2001 | Epilepsy Res2001，47，3： | 1 |
| 13 | Joint factor analysis versus eigenchannels in speaker recognition显示文摘 | Kenny P Boulianne G Ouellet P | 2007 | IEEE Transactions on Audio Speech and Language Processing2007，15，4： | 1 |
| 14 | Anode Baking Furnace Modeling for Process op-Timization 显示文摘 | OUELLET R | 1995 | Light Metals1995，66，5： | 1 |
| 15 | Comparison of the aetiology of stillbirth over five decades in a single centre:a retrospective study显示文摘 | Wou K Ouellet MP Chen MF | 2014 | BMJ Open2014，4，00： | 1 |
| 16 | From gene profiling to diagnostic markers:IL-18 and FGF-2 complement CA125 as serum-based markers in epithelial ovarian cancer显示文摘 | Le PAGE C OUELLET V MADORE J | 2006 | Int J Cancer2006，18，7： | 1 |
| 17 | Production of the antimalarial drug precursor artemisinic acid in engineered yeast显示文摘 | Ro DK Paradise EM Ouellet M | 2006 | Nature2006，440，7086： | 1 |
| 18 | Subjective and objective measures ofinsomnia in the context of traumatic brain injury;a preliminarystudy显示文摘 | Ouellet M C Morin C M | 2006 | Sleep Med2006，7，： | 1 |
| 19 | Molecular verification and characterization of BYDV-resistant germ plasms derived from hybrids of wheat with Thinopyrum ponticum and Th. intermedium显示文摘 | X. Y. Zhang A. Koul R. Petroski T. Ouellet G. Fedak Y. S. Dong R. R. C. nWang | 1996 | Theoretical and Applied Genetics1996，，7： | 1 |
| 20 | Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers显示文摘 | OUELLET D HSU A QIAN J | 1998 | Br J Clin Pharmacol1998，46，2： | 1 |
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