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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 3 | A 'region-growing' algorithm for matching of terrain images显示文摘 | OTTO G P CHAU T K W | 1989 | Image and Vision Computing1989，7，2： | 1 |
| 4 | Characterization of PdJgamma-Alumina catalysts containing ceria 显示文摘 | Shyu J Z Otto K Watkins W L H | 1988 | J Catal1988，，114： | 1 |
| 5 | 'Region-growing” algorithm for matching of terrain images显示文摘 | Otto G P Chau T K W | | 0，，02： | 1 |
| 6 | Modutar product architecture显示文摘 | DAHMUS J B GONZALEZ-ZUGASTI J P OTTO K N | 2001 | Design Studies2001，22，5： | 1 |
| 7 | Modular Product architecture 显示文摘 | Dahmus J Gonzalez-Zugasti J Otto K | 2001 | DesignStudies2001，22，5： | 1 |
| 8 | Incorporating design effort complexity measures in product architectural design assessment 显示文摘 | Holtta K Otto K | 2005 | Design Studies2005，26，5： | 1 |
| 9 | Developmental outcome and psychosocial adjustment in children after surgery for congenital heart disease during infancy 显示文摘 | Katja H Karl - Otto D Herman K | 2007 | SRIP2007，25，2： | 1 |
| 10 | Sigmoid sinus diverticulum: a new surgical approach to the correction of pulsatile tinnitus显示文摘 | OTTO K J HUDGINS P A ABDELKAFY W | 2007 | Otol Neurotol2007，28，： | 1 |
| 11 | Minimised gear lubrica-tion by a minimum oil/air flow rate显示文摘 | Hohn B R Michaelis K Otto H P | 2009 | Wear2009，266，34： | 1 |
| 12 | Volumetric modulated arc therapy:IMRT in a single gantry arc显示文摘 | Otto K | | 0，，01： | 1 |
| 13 | Volumetric modulated arc therapy: IMRT in a single gantry arc显示文摘 | Otto K | 2008 | Med Phys2008，35，： | 1 |
| 14 | Occurrence of phthalates and bisphenol A and F in the environment 显示文摘 | Fromme H Kuchler T Otto T Pilz K Miiller J Wenzel A | 2002 | Water Research2002，36，： | 1 |
| 15 | Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly 显示文摘 | OTtO C M LIND B K KITZMAN D W | 1999 | N Engl J Med1999，341，1： | 1 |
| 16 | Positive conceptions of perfectionism:Approaches,evidence,challenges显示文摘 | Stoeber J Otto K | 2006 | Personality and Social Psychology Review2006，10，6： | 1 |
| 17 | A method for architecting product platforms显示文摘 | GONZALER-ZUGASTI J P OTTO K N BAKER J D | 2000 | Research in Engineering Deslgn2000，12，2： | 1 |
| 18 | Therapy-induced T cell responses against the universal tumor antigen Survivin显示文摘 | Otto K Andersen M H Eggert A | 2005 | Vaccine2005，23，7： | 1 |
| 19 | Volumetric modulated arc therapy: IMRT in a single gantry arc显示文摘 | Otto K | 2008 | Med Phys2008，35，1： | 1 |
| 20 | Friction experiments for filament winding applications显示文摘 | Sotiris K Otto K B | 2006 | Journal of Thermoplastic Composite Materials2006，19，5： | 1 |
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