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| 1 | Complications and survival in patients undergoing colonic stenting for malignant obstruction显示文摘AIM:To investigate whether predicting patients that might be at a higher risk for complications might serve to improve the selection of patients undergoing colonic stenting.METHODS:A retrospective review of consecutive patients who underwent an attempted self-expandable metal stent(SEMS)insertion for malignant colonic obstruction between November 2006 and March 2013.All patients were either referred for preoperative colonic decompression with the intent of a single surgical procedure,or for palliation of the malignant colorectal obstruction for unresectable cancer.Fisher’s test orχ2test was performed on categorical variables,and the t test for continuous variables.Univariable and multivariable logistic regression were used to examine the association between independent variables and the presence of complications from SEMS insertion.RESULTS:SEMS insertion was attempted in 73 patients.Males comprised 55.71%and the mean age was 67.41±12.41 years.Of these,65.15%underwent subsequent surgery,while 34.85%received SEMS as palliation for advanced disease.Extracolonic tumors were only4.76%.The majority of patients had stageⅣdisease(63.83%),while the remainder had stageⅢ(36.17%).SEMS were successfully inserted in 93.85%(95%CI:87.85%-99.85%).Perforations occurred in 4.10%,SEMS migration in 8.21%,and stent re-occlusion from ingrowth occurred in 2.74%of patients.The mean duration of follow up for the patients was 13.52±17.48 mo(range 0-73 mo).None of the variables:age,sex,time between the onset of symptoms to SEMS insertion,time between SEMS insertion and surgery,length of the stenosis,location of the stenosis,albumin level,or receiving neoadjuvant chemotherapy,could predict the development of complications from either SEMS insertion nor prolonged survival.CONCLUSION:None of the variables could predict the development of complications or survival.Further studies are required to identify patients who would benefit the most from SEMS. | Majid A Almadi Nahla Azzam Othman Alharbi Alabbas H Mohammed Nazia Sadaf Abdulrahman M Aljebreen | 2013 | World Journal of Gastroenterology2013，19，41： | 5 |
| 2 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 3 | Vitamin D status and viral response to therapy in hepatitis C infected children显示文摘AIM: To study the frequency of vitamin D deficiency in patients with hepatitis C virus(HCV) infection and to evaluate the role of vitamin D supplementation in improving antiviral therapy.METHODS: Sixty-six children aged from 7-14 years(mean ± SD, 11.17 ± 2.293) diagnosed with HCV infection were matched to 28 healthy controls. Serum levels of 25(OH) D3, calcium, phosphorus, alkaline phosphatase and plasma level of parathormone were measured. Quantitative PCR for HCV was performed Bone density was determined by dual energy X-ray absorptiometry. All cases received conventional therapy, and only 33 patients received vitamin D supplementation.RESULTS: Children with HCV showed significantly increased levels of HCV RNA(P < 0.001), parathormone(P < 0.01) and decreased vitamin D levels(P < 0.05)(33.3% deficient and 43.3% insufficient) compared with controls. Abnormal bone status(Z score-1.98 ± 0.75) was found in ribs, L-spine, pelvis and total body. Cases treated with vitamin D showed significant higher early(P < 0.04) and sustained(P < 0.05) virological response. There was a high frequency of vitamin D deficiency among the Egyptian HCV children, with significant decrease in bone density. The vitamin D level should be assessed before the start of antiviral treatment with the correction of any detected deficiency. CONCLUSION: Adding vitamin D to conventional Peg/RBV therapy significantly improved the virological response and helped to prevent the risk of emerging bone fragility. | Azza A Eltayeb Madleen Adel A Abdou Amal M Abdel-aal Mostafa H Othman | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 4 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 5 | Energy Consumption, Economic Growth and Environmental Pollutants in Indonesia 显示文摘 | Jafari Y Othman J Nor A H S M | 2012 | Journal of Policy Modeling2012，34，6： | 1 |
| 6 | The effect of chitosan load- ing on the curing characteristics, mechanical and morphologi- cal properties of chitosan-filled natural rubber(NR) , epoxi- dised natural rubber (ENR) and styrene-butadiene rubber (SBR) compounds 显示文摘 | Ismail H Shaari S M Othman N | 2011 | Polymer Testing2011，30，7： | 1 |
| 7 | Performance analysis of a double-pass photovoltaic/thermal (PV/T) solar collector with CPC and fins显示文摘 | OTHMAN M Y H YATIM B SOPIAN K | 2005 | Renewable Energy2005，30，13： | 1 |
| 8 | Safety, tolerability and pharmacokineties of the histamine H3 receptor antagonist, ABT - 288, in healthy young adults and elderly volunteers显示文摘 | Othman AA Haig G Florian H | 2013 | Br J Clin Pharmacol2013，75，： | 1 |
| 9 | Processing condi- tions-fracture toughness relationships of asphalt con- crete mixtures 显示文摘 | Aglan H Othman A Figueroa L | 1994 | Journal of Materials Science1994，29，18： | 1 |
| 10 | An automated cervi- cal pre-cancerous diagnostic system 显示文摘 | Mat-lsa N A Mashor M Y Othman N H | 2008 | Artificial Intelligence in Medicine2008，42，1： | 1 |
| 11 | Hydraulic conductivity of compacted clay frozen and thawed in situ显示文摘 | Benson C H Othman M A | 1993 | Journal of Geotechnical Engineering1993，119，2： | 1 |
| 12 | Barrier integrity of punctured gloves:NR superior to vinyl and nitrile显示文摘 | HASHIM H OTHMAN A B | 2003 | Journal of Natural Rubber Research2003，6，4： | 1 |
| 13 | Adsorption of methylene blue on low-cost adsorbents:A review显示文摘 | Mohd R Othman S Rokiah H | 2010 | J Hazard Mater2010，177，123： | 1 |
| 14 | Effect of freeze-thaw on the hydraulic conductivity and morphology of compacted clay显示文摘 | Othman M A Benson C H | 1993 | Canadian Geotechnical Journal1993，30，2： | 1 |
| 15 | Enhanced photoluminescence of Tb3 + and Eu3 + induced by energy transfer from SnO2 and Si nanocrystallites显示文摘 | Elhouichet H Othman L Moadhen A | 2003 | Materials Science and Engineering B2003，15，13： | 1 |
| 16 | Flexural behavior of engi- neered cementitious composites (ECC) slabs with polyvinyl alco- hol fibers 显示文摘 | SAID S H RAZAK H A OTHMAN I | 2015 | Construction and Building Materials2015，75，： | 1 |
| 17 | Genome constitution and classification using retrotransposon-based markers in the orphan crop banana显示文摘 | TEO C H TAN S H HO C L FARIDAH Q Z OTHMAN Y R HESLOP-HARRISON J S KALENDAR R SCHULMAN A H | 2005 | J Plant Bio2005，48，： | 1 |
| 18 | Organochlorine pesticide residues in sediments and biota from the coastal area of Dar es Salaam city,Tanzania显示文摘 | MWEVURA H OTHMAN O C MHEHE G L | 2002 | Marine Pollution Bulletin2002，45，： | 1 |
| 19 | Squalene based nanoeomposites: a new platform for the design of multifunetional pharmaceutical theragnostics显示文摘 | Arias J L Reddy L H Othman M | 2011 | A CS Nano2011，5，： | 1 |
| 20 | Performance analysis of a double-pass photovoltaic/ thermal (PV/T) solar collector with CPC and fins 显示文摘 | OTHMAN M Y H YATIM B SOPIAN K | 2005 | Renewable Energy2005，30，13： | 1 |
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