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| 1 | Bile-acid-induced cell injury and protection显示文摘Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. Several pathways are involved in triggering hepatocyte apoptosis. Toxic BAs can activate hepatocyte death receptors directly and induce oxidative damage, thereby causing mitochondrial dysfunction, and induce endoplasmic reticulum stress. When these compounds are taken up and accumulate inside biliary cells, they can also cause apoptosis. Regarding extrahepatic tissues, the accumulation of BAs in the systemic circulation may contribute to endothelial injury in the kidney and lungs. In gastrointestinal cells, BAs may behave as cancer promoters through an indirect mechanism involvingoxidative stress and DNA damage, as well as acting as selection agents for apoptosis-resistant cells. The accumulation of BAs may have also deleterious effects on placental and fetal cells. However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity, due in part to an enhancement in glutathione levels; and the inhibition of liver cell apoptosis. Other natural BAs or their derivatives, such as cholyl-N- methylglycine or cholylsarcosine, have also aroused pharmacological interest owing to their protective properties. | Maria J Perez Oscar Briz | 2009 | World Journal of Gastroenterology2009，15，14： | 53 |
| 2 | Overall rate, location, and predictive factors for positive surgical margins after robot-assisted laparoscopic radical prostatectomy for high-risk prostate cancer显示文摘我们与高风险的前列腺癌症在 271 个病人报导全面的率,地点和积极外科的边缘(PSM ) 的预兆的因素。在 2008 年 4 月和 2011 年 10 月之间,我们有希望地从作为 D'Amico 分类的病人收集了数据高风险经历了帮助机器人的 laparoscopic 激进分子前列腺切除术。PSM 的全面的率和地点被报导。逐步的逻辑回归模型被适合估计 PSM 的预兆的因素。PSM 的全面的率是 25.1%(271 个病人中的 68 个) 。这些 PSM,(68 中的 26 个)38.2% 是 posterolateral (PL ) , 26.5%(68 中的 18 个) multifocal, 16.2%(68 中的 11 个) 在顶, 14.7%(68 中的 10 个) 在膀胱颈,并且 4.4%(3/68 ) 在另外的地点。有病理学的阶段 pT2 的病人的 PSM 率是 8.6%(140 中的 12 个) , 26.6%(64 中的 17 个) pT3a, 53.3%(32/60 ) pT4 的 pT3b,和 100%(7 中的 7 个) 。在包括 pre- , intra- ,和手术后的参数的一个逻辑回归模型,身体团索引(机会比率[或] :1.09;95% 信心间隔[CI ] :1.01-1.19, P= 0.029 ) ,病理学的舞台(pT3b 或更高对 pT2;或:5.14;95% CI:1.92-13.78;P = 0.001 ) 并且肿瘤的百分比(或:46.71;95% CI:6.37-342.57;P < 0.001 ) 是为 PSM 的独立预兆的因素。在病人在的 PSM 的最普通的地点高风险是 PL 方面,它反映报导肿瘤攻击性。PSM 的唯一的重要预兆的因素是病理学的结果,例如在标本和病理学的舞台的肿瘤的百分比。 | Sung Gu Kang Oscar Schatloff Abdul Muhsin Haidar Srinivas Samavedi Kenneth J Palmer Jun Cheon Vipul R Patel | 2016 | Asian Journal of Andrology2016，18，1： | 9 |
| 3 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 4 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 5 | Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001显示文摘AIM: To evaluate how proximal colon polyps interpreted as hyperplastic polyps in 2001 would be interpreted by expert pathologists in 2007. METHODS: Forty consecutive proximal colon polyps ≥ 5 mm in size, removed in 2001, and originally interpreted as hyperplastic polyps by general pathologists at Indiana University, were reviewed in 2007 by 3 GI pathologists. RESULTS: The gastrointestinal (GI) pathologists interpreted 85%, 43% and 30% of the polyps as sessile serrated polyps (sessile serrated adenomas). The overall Kappa was 0.16. When diagnoses were compared in pairs, Kappa values were 0.38 and 0.25 (fair agreement) and 0.14 (slight agreement). CONCLUSION: Many polyps interpreted as hyperplastic in 2001 were considered sessile serrated lesions by GI pathologists in 2007, but there is substantial inter-observer variation amongst GI pathologists. | Omer Khalid Sofyan Radaideh Oscar W Cummings Michael J O'Brien John R Goldblum Douglas K Rex | 2009 | World Journal of Gastroenterology2009，15，30： | 3 |
| 6 | Mapping aboveground biomass by integrating geospatial and forest inventory data through a k-nearest neighbor strategy in North Central Mexico显示文摘As climate change negotiations progress,monitoring biomass and carbon stocks is becoming an important part of the current forest research.Therefore,national governments are interested in developing forest-monitoring strategies using geospatial technology.Among statistical methods for mapping biomass,there is a nonparametric approach called k-nearest neighbor(kNN).We compared four variations of distance metrics of the kNN for the spatially-explicit estimation of aboveground biomass in a portion of the Mexican north border of the intertropical zone.Satellite derived,climatic,and topographic predictor variables were combined with the Mexican National Forest Inventory(NFI)data to accomplish the purpose.Performance of distance metrics applied into the kNN algorithm was evaluated using a cross validation leave-one-out technique.The results indicate that the Most Similar Neighbor(MSN)approach maximizes the correlation between predictor and response variables(r=0.9).Our results are in agreement with those reported in the literature.These findings confirm the predictive potential of the MSN approach for mapping forest variables at pixel level under the policy of Reducing Emission from Deforestation and Forest Degradation(REDD+). | Carlos A AGUIRRE-SALADO Eduardo J TREVIO-GARZA Oscar A AGUIRRE-CALDERóN Javier JIMNEZ-PREZ Marco A GONZLEZ-TAGLE José R VALDZ-LAZALDE Guillermo SNCHEZ-DíAZ Reija HAAPANEN Alejandro I AGUIRRE-SALADO Liliana MIRANDA-ARAGóN | 2014 | Journal of Arid Land2014，6，1： | 3 |
| 7 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 8 | Rivero,Inmaculada Ortiz,Photo-Fenton process as an efficient alternative tothe treatment of landfill leachates显示文摘 | Oscar Primo Mar'Ia J | 2008 | Journal of Hazardous Materials2008，，153： | 1 |
| 9 | New pseudopterosin and seco-pseudopterosin diterpene glycosides from two Colombian isolates of Pseudopterogorgia elisabethae and their diverse biological activities显示文摘 | Rodriguez Ⅱ Shi Y P Oscar J G | 2004 | J Nat Prod2004，67，： | 1 |
| 10 | Evolution of a Nearshore Coastal Observatory显示文摘 | OSCAR S ROBERT J C JOSH K SCOTT G | 2003 | Sea Technology2003，，11： | 1 |
| 11 | The effect of competi- tion on individual tree basal area growth in mature stands of Pinus cooped blanco in Durango (Mexico) 显示文摘 | Corral R J Alvarez Gonzalez J Oscar A | 2005 | European Journal of Forest Research2005，124，2： | 1 |
| 12 | Fuel ethanol production: Process design trends and integration opportunities 显示文摘 | Carlos A Cardonaa Oscar J Sanchez | 2007 | Bioresource Technology2007，，98： | 1 |
| 13 | 显示文摘 | Peruzzo Pablo J Anbinder Pab!o S Pardini Oscar R | 2011 | Progress in Organic Coatings2011，，72： | 1 |
| 14 | Secondary ettringite formation in concrete subjected to different curing conditions显示文摘 | OSCAR R B MILANESI A C MAIZA P J | 2000 | Cement and Concrete Research2000，30，9： | 1 |
| 15 | High Temperature Mechanical Behavior of a 30% Ni - 19% Cr Steel 显示文摘 | Jose A J Oscar A R Maria T L | 2003 | ISIJ International2003，，12： | 1 |
| 16 | Chattering detection in cylindrical grinding processes using the wavelet transform 显示文摘 | OSCAR G B EDUARDO R JUAN C J | 2006 | International Journal of Machine Tools& Manufacture2006，46，12： | 1 |
| 17 | Polyurethane/acrylate hybrids : effects of the acrylic content and thermal treatment on the polymer properties 显示文摘 | Pablo J P Pablo S A Oscar R P | 2010 | Journal of Applied Polymer Science2010，116，： | 1 |
| 18 | Carbon monitoring costs and their effect on incentives to sequester carbon through forestry显示文摘 | OSCAR J C RUSSELL M W KENNETH G M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，，154： | 1 |
| 19 | Age and Racial Variation in Central Corneal Thickness of Preschool and School-aged Children显示文摘 | Haider Kathryn M Mickler Casey Oliver Dana Moya Frank J Cruz Oscar A Davitt Bradley V | 2008 | Journal of Pediatric Ophthalmology and Strabismus2008，，4： | 1 |
| 20 | Polyure- thane/Acrylate hybrids : Effect of the Acrylate Content and Thermal Treatment on the Polymer Properties 显示文摘 | Pablo J Peruzzo Pablo S Anbinder Oscar R Paradini | 2010 | Journal of Applied Poly- mer Science2010，116，5： | 1 |
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