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| 1 | 铅对肾上腺皮质细胞线粒体的氧化损伤显示文摘【目的】研究铅对肾上腺皮质细胞氧化应激和线粒体功能的影响 ,为了解其肾上腺皮质毒作用机制提供依据。【方法】原代分离培养豚鼠肾上腺皮质细胞 ,以 0、6 2 5、12 5、2 5、5 0、10 0 μmol/L醋酸铅 (PbAc)处理细胞 ,观察PbAc诱导肾上腺皮质细胞活性氧 (ROS)产生和线粒体损伤作用。ROS检测采用荧光分光光度法 ,线粒体膜电位 (MMP)和细胞存活状态采用Rh12 3和PI双标记、流式细胞术检测 ,细胞ATP水平采用化学发光法测定。【结果】PbAc染毒后肾上腺皮质细胞ROS形成水平随剂量增加而增加 ,具有剂量效应关系 [^y=4 16 +10 2 1× 1g(x+1) ,P <0 0 1,R2 =0 6 41];线粒体膜电位呈剂量依赖性降低 ,Rh12 3的平均荧光强度 (MFI)在 6 2 5~ 10 0 μmol/L各剂量组依次为 1 0 1,0 94,0 96 ,0 95和 0 91,与对照组(1 35 )比较具有显著性差异 (P <0 0 1) ;染毒后细胞死亡率轻度增加 ,与对照组 (1 0 2 % )比较 ,5 0 μmol/L和 10 0 μmol/L的PbAc组分别为 3 16 %和 3 40 % ,差异具有显著性 (P <0 0 5 ) ;ATP水平降低与PbAc剂量之间存在剂量效应关系 [^y =2 12 96 5 7- 5 15 92 5× 1g(x +1) ,P <0 0 1,R2 =0 5 6 8],剂量和时间对ATP水平的影响呈协同抑制作用 (P <0 0 1)。【结论】线粒体氧化应激介导肾? | 杨杏芬 庄志雄 魏青 凌莉 范瑞泉 Shen H M Ong C N | 2001 | 中山医科大学学报2001，22，1： | 8 |
| 2 | Assessment of lymph node involvement in colorectal cancer显示文摘Lymph node metastasis informs prognosis and is a key factor in deciding further management, particularly adjuvant chemotherapy. It is core to all contemporary staging systems, including the widely used tumor node metastasis staging system. Patients with nodenegative disease have 5-year survival rates of 70%-80%, implying a significant minority of patients with occult lymph node metastases will succumb to disease recurrence. Enhanced staging techniques may help to identify this subset of patients, who might benefit from further treatment. Obtaining adequate numbers of lymph nodes is essential for accurate staging. Lymph node yields are affected by numerous factors, many inherent to the patient and the tumour, but others related to surgical and histopathological practice. Good lymph node recovery relies on close collaboration between surgeon and pathologist. The optimal extent of surgical resection remains a subject of debate. Extended lymphadenectomy, extra-mesenteric lymph node dissection, high arterial ligation and complete mesocolic excision are amongst the surgical techniques with plausible oncological bases, but which are not supported by the highest levels of evidence. With further development and refinement, intra-operative lymphatic mapping and sentinel lymph node biopsy may provide a guide to the optimum extent of lymphadenectomy, but in its present form, it is beset by false negatives, skip lesions and failures to identify a sentinel node. Once resected, histopathological assessment of the surgical specimen can be improved by thorough dissection techniques, step-sectioning of tissue blocks and immunohistochemistry. More recently, molecular methods have been employed. In this review, we consider the numerous factors that affect lymph node yields, including the impact of the surgical and histopathological techniques. Potential future strategies, including the use of evolving technologies, are also discussed. | Mark L H Ong John B Schofield | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 8 |
| 3 | Season of the year influences infection rates following total hip arthroplasty显示文摘AIM To research the influence of season of the year on periprosthetic joint infections.METHODS We conducted a retrospective review of the entire Medicare files from 2005 to 2014. Seasons were classified as spring, summer, fall or winter. Regional variations were accounted for by dividing patients into four geographic regions as per the United States Census Bureau(Northeast, Midwest, West and South). Acute postoperative infection and deep periprosthetic infections within 90 d after surgery were tracked. RESULTS In all regions, winter had the highest incidence of periprosthetic infections(mean 0.98%, SD 0.1%) and was significantly higher than other seasons in the Midwest, South and West(P < 0.05 for all) but not the Northeast(P = 0.358). Acute postoperative infection rates were more frequent in the summer and were significantly affected by season of the year in the West.CONCLUSION Season of the year is a risk factor for periprosthetic joint infection following total hip arthroplasty(THA). Understanding the influence of season on outcomes following THA is essential when risk-stratifying patients to optimize outcomes and reduce episode of care costs. | Samuel Rosas Alvin C Ong Leonard T Buller Karim G Sabeh Tsun yee Law Martin W Roche Victor H Hernandez | 2017 | World Journal of Orthopedics2017，8，12： | 4 |
| 4 | 重新审视β受体阻滞剂在高血压及心血管疾病中的地位显示文摘β受体阻滞剂可降低心肌梗死后的死亡率,并改善收缩性心力衰竭患者的预后;可减少高风险患者手术前治疗的不良事件;在较年轻的患者中(60岁以下),β受体阻滞剂的疗效与其它抗高血压药物相似;β受体阻滞剂可能改善冠心病的预后,并延缓疾病的进展;在预防高血压患者的心血管事件方面,阿替洛尔的疗效可能不如其它β受体阻滞剂以及其它抗高血压药物。 | H T Ong 张海燕(编译) | 2007 | 中国处方药2007，6，6： | 2 |
| 5 | Noor Grafting of sodium carboxymethylcellulose (CMC) with glycidyl methacrylate and development of UV curable coatings from CMC-g-GMA induced by cationic photoinitiators显示文摘 | Lin Ong Hui Kumar R N Rozman H D | 2005 | Carbohydrate Polymers2005，59，1： | 1 |
| 6 | Moving element method for train-track dynamics显示文摘 | Koh C G Ong J S Y Chua D K H Feng J | 2003 | International Journal for Numerical Methods in Engineering2003，56，： | 1 |
| 7 | Connectivity-based multiple-circle fitting显示文摘 | Qiao Yu Ong S H | 2004 | Pattern Recognition2004，37，4： | 1 |
| 8 | Peripherally inserted centralcatheters and upper extremity deep vein thrombosis 显示文摘 | Ong B Gibbs H Catchpole I | 2006 | Australas Radiol2006，50，： | 1 |
| 9 | Predictors of nonalcoholic ste- atobepatitis and advanced fibrosis in morbidly obese patients 显示文摘 | Ong JP Elariny H Collantes R | 2005 | Obesity Surgery2005，15，： | 1 |
| 10 | Research frontier: memetic computation-past,present & future 显示文摘 | ONG Y S LIM M H CHEN Xian-shun | 2010 | IEEE Computational Intelli- gence Magazine2010，5，2： | 1 |
| 11 | Regulatory role of T cells in a murine model of lymphoproliferative disease 显示文摘 | Raveche E Fernandes H Ong H | 1998 | Cellular Immunology1998，187，： | 1 |
| 12 | Magnetic properties of BaFe12-2xZnxZrxO19 particles显示文摘 | WEI F L FANG H C ONG C K | 2000 | J Appl Phys2000，87，： | 1 |
| 13 | Critical cooling rates for glass formation in Zr-Al-Cu-Ni alloys 显示文摘 | HNG H H LI Y NG S C ONG C K | 1996 | J Non-Cryst Solids1996，208，12： | 1 |
| 14 | Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia Miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells 显示文摘 | Liu J Shen H M Ong C N | 2001 | Life Sciences2001，69，16： | 1 |
| 15 | Vertebral artery domi- nance contributes to basilar artery culwatult and peri-verte brobasilar junctional infarcts显示文摘 | H ong J M Chung CS Bang OY | 2009 | J Neurol Neurosurg Psychia- try2009，80，： | 1 |
| 16 | Factors inurning chloride transport in concrete structures exposed to ma- rine environments显示文摘 | SONG H A-WON LEE CH ANG-H ONG KI YONGANN | 2008 | Cement and concrete composites2008，30，2： | 1 |
| 17 | Synthesis, characterization and comparative study of nano- Ag--TiO2 against Gram- positive and Gram- negative bacteria under fluorescent light 显示文摘 | BARUDIN N H A SREEKANTAN S ONG M T | 2014 | Food Control2014，，46： | 1 |
| 18 | Low temperature character/zation of nano-sized BaFe12-2xZnxSnxO19 particlesJournal of Magnetism and Magnetic Materials显示文摘 | Fang H C Ong C K Zhang X Y | 1999 | Journal of Magnetism and Magnetic Materials1999，191，： | 1 |
| 19 | Wastewater treatment with bacterial augmentation显示文摘 | Chin K K Ong S L Poh L H | 1998 | Water Sci Technol1998，33，8： | 1 |
| 20 | Long wave ultrasound may enhance bone regeneration by altering OPG/RANKL ratio in human osteo- blast-like cells显示文摘 | Maddi A Hal H Ong ST | 2006 | Bone2006，39，2： | 1 |
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