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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hqoqpup0b6pqu6pcw.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 3 | Interplay between proliferation and differentiation within the myogenic lineage显示文摘 | Olson E N | 1992 | Dev Biol1992，154，： | 2 |
| 4 | Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress显示文摘 | FREY N BARRIENTOS T OLSON E N | 2004 | Nature Medicine2004，10，12： | 1 |
| 5 | Contributions of residue 45(CD3) and heme-6-propionate to the bimolecular and geminate recombination reactions of myoglobin显示文摘 | Carver T E Olson J S | 1991 | Biochemistry1991，30，： | 1 |
| 6 | Gap filling strategies for long term energy flux data sets显示文摘 | Falge E Baldocchi D Olson R J | 2001 | Agricultural and Forest Meteorology2001，107，1： | 1 |
| 7 | MieroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets显示文摘 | van Rooij E Olson EN | 2007 | J Clin In- vest2007，117，9： | 1 |
| 8 | Giardia and Cryptosporidium in Canadian farm animals显示文摘 | Olson M E Thorlakson C L DEselliers L et a1 | 1997 | Vet Parasitol1997，68，4： | 1 |
| 9 | The many roles of histone deacetylases in development and physiology: implications for disease and therapy 显示文摘 | Haberland M Montgomery R L Olson E N | | Nat Rev Genet0，10，1： | 1 |
| 10 | Role of Derlin-I protein in proteostasis regulation of ATP-sensitive potas- sium channels显示文摘 | WANG F OLSON E M SHYNG S L | 2012 | J Biol Chem2012，287，10： | 1 |
| 11 | Individual differences in the development of early peer aggression:integrating contributions of self-regulation,theory of mind,and parenting显示文摘 | OLSON S L LOPEZ-DURAN N LUNKENHEIMER E S | 2011 | Dev Psychopathol2011，23，1： | 1 |
| 12 | Effects of hyperoxia on VEGF, its receptors, and HIF- 2alpha in the newborn rat lung 显示文摘 | HOSFORD G E OLSON D M | 2003 | Am J Physiol Lung Cell Mol Physiol2003，285，1： | 1 |
| 13 | The role of chemokines in term and premature rupture of the fetal membranes; a review显示文摘 | Gomez-Lopez N Laresgoiti-Servitje E Olson DM | 2010 | Biol Reprod2010，82，5： | 1 |
| 14 | Opportunities for im- proving milk production efficiency in dairy cattle: triennial lactation symposium 显示文摘 | Connor E E Hutchison J L Olson K M | 2011 | J Anim Sci2011，90，： | 1 |
| 15 | Gap filling strategies for defensible annual sums of net ecosystem exchange显示文摘 | Falge E Baldocchi D Olson R | 2001 | Agricultural and Forest Meteorology2001，107，： | 1 |
| 16 | Cardiac plasticity显示文摘 | Hill J A Olson E N | 2008 | New England J Med2008，358，13： | 1 |
| 17 | Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins显示文摘 | FREY N OLSON E N | 2002 | J Biol Chem2002，277，13： | 1 |
| 18 | Signaling pathways in skeletal muscle remodeling显示文摘 | BASSEL - DUBY R OLSON E N | 2006 | Annu Rev of Biochem2006，75，： | 1 |
| 19 | Biology of Cryptosporidium parvum in pigs:from weaning to market显示文摘 | Guselle N J Appelbee A J Olson M E | 2003 | Vet Parasitol2003，113，1： | 1 |
| 20 | Spatial and temporal distributtons of prochlorophyte picoplankton in the North Atlantic Ocean显示文摘 | Olson R L Chisholm S W Zettler E R | 1990 | Deep Sea Research1990，37，： | 1 |
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