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	题名	作者	年代	出处	被引量
1	Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria.	José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez	2015	World Journal of Transplantation2015，5，1：	6
2	Cracking control of concretes modified with short AR-glass fibers at early age, Experimental results on standard concrete and SCC 显示文摘	Barluenga G Herndndez- Olivares F	2007	Cement and Concrete Research2007，37，12：	1
3	Essentiality of copper in humans显示文摘	UAUY R OLIVARES M MAURICIO G	1998	Am J Clin Nutr1998，，：	1
4	Antimicrobial susceptibility of Helicobacter pylori and mechanisms of clarithromycin resistance in strains isolated from patients in Uruguay显示文摘	Torres-Debat M E Prez-Prez G Olivares A	2009	Rev Esp Enferm Dig2009，101，5：	1
5	Transcriptional and posttranslational upregulation of HER3(ErbB3) compensates for inhibition of the HER2 tyrosine kinase显示文摘	GARRETT J T OLIVARES M G RINEHART C	2011	Proc Natl Acad Sci2011，108，12：	1
6	Stabilization of periodic orbits of the buck converter by timedelayedfeedback显示文摘	Batle C Fossas E Olivar G	1999	International Journal of Circuit Theory and Applications1999，27，5：	1
7	Apoptosis is increased and cell proliferation is decreased in out-of-phase endometria from infertile and recurrent abortion patients显示文摘	Meresman G F Olivares C Vighi S	2010	Reprod Biol Endocri- nol2010，8，：	1
8	Study of Chaos in the Buck Converter显示文摘	Fossas E Olivar G	1995	IEEE Transaction on Circuits and System1995，43，1：	1
9	Antimicrobial susceptibility of Helicobacter pylori and mechanisms of clarithromycin resistance in strains isolated from patients in Uruguay显示文摘	Torres-Debat ME Perez-Perez G Olivares A	2009	Rev Esp Enferm Dig2009，101，：	1
10	Predictors of major infections in systemic lupus erythematosus显示文摘	Ruiz-Irastorza G Olivares N Ruiz-Arruza I	2009	Arthritis Res Ther2009，11，4：	1
11	Static and Dynamic Behavior of Recycled Tyre Rubber-filled Concrete 显示文摘	Hernandez Olivares F Barluenga G Bollatib M	2002	Cement Concrete Res2002，32，10：	1
12	Two-parameter discon-tinuity induced bifurcation curves in a ZAD-strategy-controlled DC-DC Buck converter 显示文摘	ANGULO F OLIVAR G BERNARDO M	2008	IEEE Transactions on Circuits and SystemsI: Regular Papers2008，55，8：	1
13	Heat transfer analysis during water spray cooling of steel rods显示文摘	MORALES R D LOPEZ A G OLIVARES I M	1990	ISIJ International1990，30，1：	1
14	Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the wnt signaling pathway显示文摘	Quintanilla RA Munoz FJ Metcalfe MJ Hitschfeld M Olivares G Godoy JA	2005	J Biol Chem2005，280，11：	1
15	lhylogenet- ie analysis of Verticillium dahliae vegetative compatibility grounps 显示文摘	Collado R M Mercado B J Olivares G C	2008	Phytopathology2008，98，9：	1
16	Predictors of major infections in systemic lupus erythematosus显示文摘	Ruiz-Irastorza G Olivares N Ruiz-Arruza I	2009	Arthritis Research&Therapy2009，11，4：	1
17	Predictors of major infections in systemic lupus erythematosus显示文摘	Ruiz-lrastorza G Olivares N Ruiz-Arruza 1	2009	Arthritis Res Ther2009，11，4：	1
18	Decidual lymphocytes of human spontaneous abortions induce apoptosis but not necrosis in JEG- 3 extravillous trophoblast cells显示文摘	Olivares EG Munoz R Tejerizo G	2002	Biol Reprod2002，67，4：	1
19	Quality of data on folic acid content in vegetables included in several Spanish food composition tables and new data on their folate content显示文摘	Olivares AB Bemal MJ Ros G	2006	Nutr Hosp2006，21，1：	1
20	PCR-based detection of Bacillus anthracis in formalin-fixed tissue from a patient receiving ciprofloxacin 显示文摘	Levine S M Perez-Perez G Olivares A	2002	J Clin Microbiol2002，40，11：	1

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