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795篇 您的检索式:作者名="O M Reilly"
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1Overview of recent advances in metastatic triple negative breast cancer显示文摘Metastatic triple negative breast cancer(TNBC)has an aggressive phenotype with a predilection for visceral organs and brain.Best responses to chemotherapy are predominately in the first line.Recent studies have demonstrated improved progression free survival with the combination of atezolizumab/pembrolizumab and chemotherapy in programmed death-ligand 1 positive metastatic TNBC.However,a recent trial in a similar population showed no benefit for atezolizumab and paclitaxel which led to a Food and Drug Administration alert.Two phase III trials(OLYMPIAD and BROCADE3)demonstrated a benefit in progression free survival(PFS)but not overall survival in patients with BRCAassociated metastatic TNBC treated with Olaparib or Talazoparib respectively.For those treated with Talazoparib,the time to deterioration in health related-quality of life was also longer compared to chemotherapy.The BROCADE3 trial demonstrated that the combination of a platinum and veliparib increased PFS in first-line metastatic TNBC but at the cost of increased toxicity.There are no headto-head comparisons of a poly(adenosine diphosphate-ribose)polymerase inhibitors(PARPi)and platinums.There are unanswered questions regarding the role of PARPi maintenance after platinum therapy as is standard of care in BRCAassociated ovarian cancer.Other areas of therapeutic interest include targeting aberrations in the phosphoinositide 3-kinase pathway,protein kinase B,mammalian target of rapamycin or utilising antibody drug conjugates.This review focusses on recent and emerging therapeutic options in metastatic TNBC.We searched PubMed,clinicaltrials.gov and recent international meetings from American Society of Clinical Oncology,San Antonio Breast Cancer Conference and the European Society of Medical Oncology.David O'Reilly Maha Al Sendi Catherine M Kelly 2021World Journal of Clinical Oncology2021,12,3:5
2Effect of semisolid microstructure on solidified phase content in 1xxx Al alloys 显示文摘Allen C M O'reilly K A Q and Cantor B 2001Acta Materialia2001,49,:2
3A rat model of bone cancer pain显示文摘S.J Medhurst K Walker M Bowes B.L Kidd M Glatt M Muller M Hattenberger J Vaxelaire T O’Reilly G Wotherspoon J Winter J Green L Urban 2002Pain2002,,:2
4A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer 显示文摘Sim B K L O'Reilly M S Liang H 1997Cancer Research1997,57,:2
5The evolving technology of DNA Fingerprinting and its application to fisheries and aquaculture 显示文摘O'Reilly P Wright J M 1995Journal of Fish Biology1995,47,:1
6Cloning of a human seventransmemhrane domain receptor, LESTR,that is highly expressed in leukocytes显示文摘Loetscher M Geiser T O'Reilly T 1994J Biol Chem1994,269,1:1
7Evolution and Revolution:Mastering the Dynamics of Innovation and Change显示文摘Tushman M L O'Reilly 1996California Man- agement Review1996,38,4:1
8Expression of angiostation eDNA in a murine fibrosarcoma suppresses primary tumor growth and produce long-term doumancy of metastases显示文摘Cao Y H O'Reilly M S Marashall B 1998J Clin Invest1998,101,5:1
9Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases显示文摘Cao Y H O'Reilly M S Marshall B 1998J Chin Ivest1998,101,:1
10The evolving technology of DNA fingerprinting and its application to fisheries and aquaculture 显示文摘O' Reilly P T Wright J M 1995Journal ofFish Biology1995,47,:1
11Azo-reductase activated budesodine prodrugs for colon targeting 显示文摘RU1Z J F M KEDZIORA K REILLY M O 2012Bioorg Med Chem Lett2012,22,24:1
12Review of automotive disc brake squeal 显示文摘KINKAID N M O'REILLY O M PAPADOPOULOS P 2003Journal of Sotmd and Vibration2003,267,1:1
13On coupled longitudinal and lateral vibrations of elastic rods显示文摘O'REILLY O M 2001Journal of Sound and Vibration2001,247,5:1
14Ambidextrous organizations: Managing evolutionary and revolutionary change显示文摘Tushman M L and O'Reilly C A 1996California Management Review1996,38,4:1
15Quantification of red blood cells using atomic force microscopy显示文摘O'Reilly M McDonnell L O'Mullane J 2001Ultramicroscopy2001,86,12:1
16Impedance formulas for planar magnetic structures with spiral windings显示文摘Hurley W G Duffy M C O'Reilly S 1999IEEE Trans on Indu Electronics1999,46,2:1
17Angiostatin :A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma 显示文摘O'Reilly M S Holmgren L Shing Y 1994Cell1994,79,21:1
18Bel-2 family gene expression during severe hyperoxia inducedlung injury 显示文摘O' Reilly M A Staversky R'J Huyck H L 2000Lab Invest2000,80,12:1
19A functional variant at a prostate cancer predispositionlocus at 8q24 is associated with PVT1 expression显示文摘Meyer KB Maia AT O'Reilly M 2011PLoS Genet2011,7,10:1
20Regulation of exoprotein gene expression in Staphylococcus aureus by agar显示文摘RECSEI P KREISWIRTH B O'REILLY M 1986Mol Gen Genet1986,202,1:1
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