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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Corticosteroids for severe influenza pneumonia: A critical appraisal显示文摘Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit(ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in s evere influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials. | Wagner Luis Nedel David Garcia Nora Jorge Ibrain Figueira Salluh Thiago Lisboa Pedro Póvoa | 2016 | World Journal of Critical Care Medicine2016，5，1： | 3 |
| 3 | Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies显示文摘 | Nora M A P Carlos A P Elsa B D | 2003 | Carbohyd Res2003，338，2： | 1 |
| 4 | Technology and Higher Education:The Impact of E-Learning Approaches on Student Academic Achievement,Perceptions and Persistence显示文摘 | Nora A Snyder B P | | 0，，： | 1 |
| 5 | An Antifungal Tetrapeptide from the culture of Penicillium canescens 显示文摘 | Brenda V B Nora I P Gabriela M C | 2009 | Chem Biod2009，6，8： | 1 |
| 6 | XAFS characterization of mercury captured from combustion gases on sorbents at low temperatures显示文摘 | Frank E H Nora Y Gerald P H | | 0，，02： | 1 |
| 7 | Cutting ege: IL-4 induces functional cell-surface expression of CXCR4 on human T cells显示文摘 | Jourdan P Abbal C Nora N Hori T Uchiyama T Vendrell JP | 1998 | J Immunol1998，160，： | 1 |
| 8 | Multiloop controller designfor a quadratic converter with a single active switch显示文摘 | RAJAGOPALAN J LEE F C NORA P | 2007 | IET ElectronPower Applm2007，，3： | 1 |
| 9 | Lal-xCaxCoO3 perovskite-type oxides: preparation, characterisation, stability, and catalyticpotentialitytbr the total oxidation of propane显示文摘 | Nora A M Bibiana P B Grange P | 2005 | Journal of Catalysis2005，231，1： | 1 |
| 10 | The inactive X chromo some adopts a unique three din, ensional conformation that is dependent on Xist RNA显示文摘 | Splinter g Wit E Nora E P | 2011 | Genes Dev2011，25，13： | 1 |
| 11 | Spatial partitioning of the regulatory landscape of the X inactivation center 显示文摘 | Nora E P Lajoie B R Schulz E G | 2013 | Nature2013，485，7398： | 1 |
| 12 | Variable length equalizers for broadband mobile systems 显示文摘 | Felip R P Noras J M David G M | 2000 | Proceedings of IEEE VTC2000，9，5： | 1 |
| 13 | Between memory and history: les lieux dememoire 显示文摘 | Nora P | 1989 | Representations1989，，26： | 1 |
| 14 | Recent advances in cheese microbiology 显示文摘 | Tom P Beresford Nora A Fitzsimons Tim M Cogan | 2001 | International Dairy Journal2001，11，： | 1 |
| 15 | Pneumonia in intubated patients:role of respiratory airway care显示文摘 | Rello J So¨nora R Jubert P | 1996 | Am J Respir Crit Care Med1996，154，1： | 1 |
| 16 | European Society of Hypertension Working Group on Obesity Obesity-induced hypertension and target organ damage: current knowledge and future directions显示文摘 | Markus P Schlaich Guido Grassi Gavin W Lambert Nora Straznicky Murray D Esler John Dixon Elisabeth A Lambert Josep Redon Krzysztof Narkiewicz Jens Jordan | 2009 | Journal of Hypertension2009，，2： | 1 |
| 17 | Linear equalizerswith dynamic and automatic length selection显示文摘 | Riera P F Noras J M Cruickshank D G M | 2001 | Electronics Letters2001，37，25： | 1 |
| 18 | Vascular Calcification Is Associated with Cortical Bone Loss in Chronic Renal Failure Rats with and without Ovariectomy: The Calcification Paradox显示文摘 | De Schutter Tineke M Neven Ellen Persy Veerle P Behets Geert J Postnov Andrei A De Clerck Nora M D’haese Patrick C | 2011 | EN2011，，4： | 1 |
| 19 | A Note on Minerals - based Sustainable De velopment : One Viable Alternative 显示文摘 | Ericsson M Noras P | 2005 | Minerals & Energy - Raw Materials Report2005，，1： | 1 |
| 20 | Regulation of X-chromosome inactivation by the X-inactivation centre显示文摘 | Augui S Nora E P Heard E | | 0，，06： | 1 |
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