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| 1 | The suppressors of cytokine signaling (SOCS) proteins:Important feedback inhibitors of cytokine action 显示文摘 | Nicola N A Greenhalgh C J | 2000 | Exp Hematol2000，28，10： | 4 |
| 2 | 运用ICF评定肌肉骨骼系统健康状况的影响显示文摘目的建议联合使用国际疾病分类(ICD)及国际功能、残疾和健康分类(ICF),并应用肌肉骨骼系统(MSK)状况的例子来说明运用方法。方法根据在ICD中MSK状况的分类和现有的ICF核心分类集(ICF Core Sets)MSK状况的类目作为备选类目来专门说明专项功能。另一方法是考虑来自在文献中出现的已经应用的测量方法或工具的类目。结果从6个MSK状况的核心分类集、两种特定的保健治疗环境、一种MSK临床研究环境和8篇工具相关的文献中抽取相关的ICF类目。结论 ICD-ICF联合使用通过考虑疾病和功能状况来强调健康状况的影响,从而促进临床保健治疗。因此,有证据显示,在ICD修订版背景下ICD和ICF之间有可操作性的联系和互补作用。 | Nenad Kostanjsek Reuben Escorpizo Annelies Boonen Nicolas E.Walsh Tefvik Bedirhan stün Gerold Stucki 李晶晶 祝捷 邹智 荀芳 邱卓英 | 2011 | 中国康复理论与实践2011，17，2： | 4 |
| 3 | Diabetic macular edema:New promising therapies显示文摘The treatment of diabetic macular edema is rapidly evolving.The era of laser therapy is being quickly replaced by an era of pharmacotherapy.Several pharmacotherapies have been recently developed for the treatment of retinal vascular diseases such as diabetic macular edema.Several intravitreal injections or sustained delivery devices have undergone phase 3 testing while others are currently being evaluated.The results of clinical trials have shown the superiority of some of these agents to laser therapy.However,with the availability of several of these newer agents,it may be difficult to individualize treatment options especially those patients respond differently to various therapies.As such,more effort is still needed in order to determine the best treatment regimen for a given patient.In this article,we briefly summarize the major new therapeutic additions for the treatment of diabetic macular edema and allude to some future promising therapies. | Hanan N Al Shamsi Jluwi S Masaud Nicola G Ghazi | 2013 | World Journal of Diabetes2013，4，6： | 4 |
| 4 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 5 | “The Art and Science of Total Synthesis at the Down of the Twenty - First Centry” Angen显示文摘 | Nicolaou KC Vourloumis D Winssinger N | 2000 | Chem Int Ed Engl2000，39，： | 1 |
| 6 | Design of symmetric conic-section flexure hinges based on closed-form compliance equations显示文摘 | Nicolae Lobontiu Jeffrey S N Paine Ephrahim Garcia | 2002 | Mechanism and Machine Theory2002，37，： | 1 |
| 7 | Aerosol inorganic ions in a semiarid region on the southeastern Spanish Mediterranean coast显示文摘 | Nicolas J F Galindo N Yubero E | 2009 | Water Air and Soil Pollution2009，201，14： | 1 |
| 8 | Correlation between 3D ultrasound appearance and postnatal findings in bilateral malforma- tions of the fetal hands显示文摘 | Muscatello A Mastrocola N Di Nicola M | 2012 | Fetal Diagn Thcr2012，31，2： | 1 |
| 9 | Detection of Epileptic Electroencephalogram Based on Permutation Entropy and Support Vector Machines显示文摘 | Nicolaou N Georgiou J | | 0，，01： | 1 |
| 10 | Role of monocyte chemoattractant protein-1(MCP-1/CCL2)in migration of neural progenitor cells toward glial tumors显示文摘 | Suresh N M Saafan Z M Nicolas C R | 2009 | J Neuro Res2009，87，7： | 1 |
| 11 | Dietary iodide controls its own absorption through post-transcriptional regulation of the intestinal Na+ /I-symporter 显示文摘 | Nicola JP Revna-Nevra A Carraso N | 2012 | J Physicl2012，590，23： | 1 |
| 12 | 'The Art and Science of Total Synthesis at the Down of the Twenty-Frist Centry' Angen显示文摘 | Vourloumis D Winssinger N | 2000 | Chem Int Ed Engl2000，39，： | 1 |
| 13 | Chemical synthesis and biolog- ical evaluation of novel epothilone B and trans-12,13-cyclopropyl epothilone B analogues显示文摘 | Nicolaou KC Ritz n A Namoto K | 2002 | Tetrahedron2002，58，32： | 1 |
| 14 | Pre-expanded ultra-thin supraclavicular flaps for (full)face reconstruction with reduced donorsite morbidity and without the need for microsurgery显示文摘 | Nicola H R N | 2005 | Plast Reconstr Surg2005，115，7： | 1 |
| 15 | An efficient tool for predicting the structural acoustic and vibration response of sandwich plates in light or heavy fluid显示文摘 | Foin O Nicolas J Atalla N | 1999 | Applied Acoustics1999，57，： | 1 |
| 16 | Design of symmetric conic-section flexure hinges based on closed-form compliance equations显示文摘 | Nicolae Lobontiu Jeffrey S N Paine | 2001 | Mechanism and Machine Theory2001，11，： | 1 |
| 17 | Design of symmetric conic-section flexure hinges based on closed-form compliance equations 显示文摘 | Nicolae Lobontiu Jaffrey S N Paine Ephrahim Garcia | 2002 | Mechanism and Machine Theory2002，37，： | 1 |
| 18 | Enzy- matic effect of hypoderminA, a parasite protease, on bovine lympho- cyte membrane antigens显示文摘 | MOIRE N NICOLAS - GAULARD I LE VERN Y | 1997 | Parasite Immunel1997，19，1： | 1 |
| 19 | Pollution by hexachlo-robenzene and pentachlorophenol in the coastat plain of Sāo Paulo state显示文摘 | Nascimento N R Nicola S M C Rezende M O O | 2004 | Geoderma2004，121，34： | 1 |
| 20 | Studies toward diazonamide A: Development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure显示文摘 | Nicolaou K C Snyder S A Giuseppone N | 2004 | J Am Chem Soc2004，126，10： | 1 |
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