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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip显示文摘 | WEINSTEIN R S NICHOLAS R W MANOLAGAS S C | 2000 | J Clin Endocrinol Metab2000，85，8： | 1 |
| 3 | Structural and mechanistic investigation of a phosphatemodified HZSM-5 catalyst for methanol conversion显示文摘 | Abubakar S M Marcus D M Lee J C Ehresmann J O Chen C Y Kletnieks P W Guenther D R Hayman M J Pavlova M Nicholas J B Haw J F | | 0，，10： | 1 |
| 4 | Field and laboratory studies of Desmodora cazca Gerlach,1956 (Desmodoridae:Nematoda) from mangrove mud-flats显示文摘 | Nicholas W L Stewart A C Marples T G | 1988 | Nematologica1988，34，3： | 1 |
| 5 | Plant antitumor agents(29): Synthesis and biological activity of ring D and ring E modified analogues of camptothecin显示文摘 | Nicholas A W Wani M C Manikumar G | 1990 | J Med Chem1990，33，3： | 1 |
| 6 | Influence of ingesting a Carbohydrate-Electrolyte Solution on Endurance Capacity During Intermittent High-intensity Shuttle Running显示文摘 | NICHOLAS C W | 1995 | J Sports Sci1995，，13： | 1 |
| 7 | An Environmental Do- main Classification of Canada Using Earth Observation Data for Biodiversity Assessment显示文摘 | Nicholas C C Michael A W Donald I | 2009 | Ecological Informatics2009，4，： | 1 |
| 8 | Substituted phenylarsonic acids; structures and spectroscopy 显示文摘 | Lloyd Nicholas C Morgan Hugh W Nicholson Brian K | 2008 | Journal of Organometallic Chemistry2008，693，14： | 1 |
| 9 | Parallel genetic simulated annealing:A massively parallel SIMD algorithm显示文摘 | Hao C Nicholas S F Daniel W W | 1998 | Parallel and Distributed Systems1998，9，2： | 1 |
| 10 | Observer bias and sub-sampling efficiencies for estimating the number of migrating fish in rivers using dual-frequency identification sonar(DIDSON)显示文摘 | Pertremana I C Nicholas E J Scott W M | 2014 | Fisheries Research2014，，155： | 1 |
| 11 | Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip显示文摘 | Weinstein R S Nicholas R W Manolagas S C | 2000 | J Clin Endocrinol Metah2000，85，9： | 1 |
| 12 | Inhibition of matrilysin expression by antisense or RNA interference decreases lysophosphatidic acid - induced epithelial ovarian cancer invasion 显示文摘 | Feng W Yoel S Nicholas C | 2006 | Mol Cancer Res2006，4，11： | 1 |
| 13 | Fermentation of cocoa beans: influence of microbial activities and flavone concentrations on the flavour of chocolate显示文摘 | NICHOLAS C TOM D W SOLOMON K A | 2008 | Journal of the Science of Food amd Agriculture2008，88，13： | 1 |
| 14 | Linkages among Commodity Futures Markets and Dynamic Welfare Analysis 显示文摘 | RAUSSER GORDON C NICHOLAS A W | 1990 | The Review of Economics and Statistics1990，，172： | 1 |
| 15 | Methylbenzenes are the organic reaction centers for methanol-to-olefin catalysis on HSAPO-34显示文摘 | SONG W G HAW J F NICHOLAS J B HENEGHAN C S | 2000 | J Am Chem Soc2000，122，10： | 1 |
| 16 | Production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α by inflammatory granuloma fibroblasts显示文摘 | Stephen W C Robert E S | 1994 | Am J Pathol1994，144，： | 1 |
| 17 | Factors which control bulk chlorine decay rates显示文摘 | JAMES C P NICHOLAS B H JOHN R W | 2000 | Water Res2000，34，1： | 1 |
| 18 | Cooperative Diversity in Wireless Networks: Efficient Protocols and Outage Behavior 显示文摘 | Nicholas L J Tse D N C Wornell Gy W | 2004 | IEEE Trans on Information Theory2004，50，12： | 1 |
| 19 | High-cycle Fatigue of Diagonally Cracked Reinforced Concrete Bridge Girders: Field Tests 显示文摘 | HIGGINS C FARROW III W C NICHOLAS B S | 2006 | Journal of Bridge Engineering2006，11，6： | 1 |
| 20 | Factors which control bulk chlorine decay rates显示文摘 | James C P Nicholas B H John R W | 2000 | Water Res2000，34，1： | 1 |
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