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| 1 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 2 | Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease显示文摘AIM: To validate novel single nucleotide polymorphisms (SNPs) in Greek patients with Crohn's disease (CD).METHODS: A total of 120 patients with CD, 85 patients with UC, and 100 unrelated healthy controls were genotyped. Genotyping was performed by allele-specific PCR or by PCR-RFLP analysis.RESULTS: Our results showed that the 1672T and -207C alleles were obviously over-represented in CD patients only (P<0.01 and P<0.05, respectively) compared to the control population. The G113A polymorphism was completely absent in our studied population. The odds ratio for the carriage of the TC haplotype was 2.21 for CD patients as compared with controls. Additionally, the frequency of the TC haplotype was increased in patients with ileocolitis or colitis, and was mainly associated with the fibrostenotic phenotype of the disease. Furthermore, when the TC haplotype was compared jointly with the carriage of at least one mutation of the NOD2/CARD15 gene, there was an increased risk for CD, but not for UC, compared to controls. Regarding the location of the disease, the concomitant presence of the TC haplotype and NOD2/CARD15 mutations was mainly associated with ileocolitis or ileitis. CONCLUSION: Collectively, our results suggest that the 1672T variant of the OCTN1 gene and the -207C variant of the OCTN2 gene represent risk factors for CD in the Greek population. | Maria Gazouli Gerassimos Mantzaris Athanassios J Archimandritis George Nasioulas Nicholas P Anagnou | 2005 | World Journal of Gastroenterology2005，11，47： | 12 |
| 3 | Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods:Association with particle constituents显示文摘Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter(PM) exposure.The presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM < 2.5 μm(PM2.5)pollution in China have led to serious concerns regarding the health effects of PM2.5during Asian sandstorms.We investigated how changes in PM2.5composition,as the weather transitioned towards a sandstorm,affected human airway epithelial cells.Six PM2.5samples covering two sandstorm events and their respective background and transition periods were collected in Baotou,an industrial city near the Gobi Desert in China.PM samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B,which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several metals.All PM samples potently increased the release of interleukin-6(IL-6) and interleukin-8(IL-8).Endotoxin in all samples contributed significantly to the IL-6 response,with only a minor effect on IL-8.Cr was positively correlated with both IL-6 and IL-8 release,while Si was only associated with the increase of IL-6.Our study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM. | Bin Wang Ning Li Furong Deng Nicholas Buglak George Park Shu Su Aiguo Ren Guofeng Shen Shu Tao Xinbiao Guo | 2016 | Journal of Environmental Sciences2016，28，9： | 9 |
| 4 | Kounis syndrome:a clinical entity penetrating from pediatrics to geriatrics显示文摘1 Introduction Kounis syndrome constitutes a coronary hypersensitivity disorder defined by the association of an anaphylactoid,anaphylactic,allergic or hypersensitivity reaction with an acute coronary syndrome,in a physiopathological context involving various interrelated and interacting inflammatory cells,such as mast-cells,eosinophils and platelets.[1,2]Similar entities to Kounis syndrome might involve cerebral and mesenteric arteries. | Mattia Giovannini Ioanna Koniari Francesca Mori Silvia Ricci Luciano De Simone Silvia Favilli Sandra Trapani Giuseppe Indolfi Nicholas George Kounis Elio Novembre | 2020 | Journal of Geriatric Cardiology2020，17，5： | 7 |
| 5 | NOD2/CARD15 , ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn’s disease显示文摘AIM: To assess whether the polymorphisms of NOD2/ CARD15 , autophagy-related 16-like 1 (ATG16L1 ), and interleukin-23 receptor (IL23R ) genes play a more critical role in the susceptibility of childhood-onset than in adult-onset Crohn’s disease (CD). METHODS: Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 ; rs2241880 A/G of ATG16L1 , and rs11209026 (R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals. Analysis of polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 genotyping was performed by allele specific polymerase chain reaction (PCR) or by PCR-restriction fragment length polymor-phism analysis. The polymorphisms rs2241880 A/G of the ATG16L1 , and rs11209026 (R381Q) of the IL23R gene in the children’s cohort were genotyped by PCR and melting curve analysis whereas adult group genotyping was performed using the Affymetrix Genome-Wide Human SNP Array 5.0 (500K). RESULTS: The 3020insC allele in NOD2/CARD15 was significantly higher in childhood than in adult-onset CD (P = 0.0067). Association with at least 1 NOD2/CARD15 variant was specific for ileal disease (with or without co- lonic involvement). Even if the frequency of G allele of the rs2241880 ATG16L1 polymorphism was increased in both paediatric and adult CD patients compared to con- trols (P = 0.017 and P = 0.001, respectively), no difference was observed between the childhood and the adult cohort. The rare Q allele of IL23R rs11209026 polymorphism was underrepresented in both paediatric and adult CD cases (P = 0.0018 and P = 0.04, respectively) and no difference was observed between the childhood and the adult cohort. The presence of the rs2241880 ATG16L1 and rs11209026 IL23R polymorphisms did not influence disease phenotype. CONCLUSION: Polymorphism 3020insC in NOD2/ CARD15 occurs statistically significantly more often in patients with childhood-onset CD than in patients with adult-onset CD. The ATG16L1 and IL23R variants are associated with susceptibility to CD, but not earlyonset disease. | Maria Gazouli Ioanna Pachoula Ioanna Panayotou Gerassimos Mantzaris George Chrousos Nicholas P Anagnou Eleftheria Roma-Giannikou | 2010 | World Journal of Gastroenterology2010，16，14： | 7 |
| 6 | The role of echocardiography and CT angiography in transcatheter aortic valve implantation patients显示文摘transcatheter 大动脉的阀门培植(TAVI ) 在于在有严重大动脉的狭窄的病人的其他的治疗。Multimodality 成像使用 transthoracic echocardiography (TTE ) 或 transesophageal echocardiography (脚趾) 和 multislice CT (MSCT ) 为外科手术前的管理组成奠基石技术,仙子程序的指导,列在后面在上面并且可能的 transcatheter 阀门的识别联系了复杂并发症。CT angiography 关于大动脉的体环直径和环绕的区域的全部的定义是更精确的。二维(2D ) echocardiography,与 3D 成像技术(MSCT, MRI 和 3D 脚趾) 相比低估大动脉的阀门体环直径。三维的脚趾成像提供类似于 MSCT 交付的那些的大动脉的阀门体环的大小。pre 程序的 MSCT 组成最小化 paravalvular 的存在的标准答案形式大动脉的流回,最经常的复杂并发症之一。TOE/TTE 和 MSCT 性能能预言心律调整器培植 procedural 以后的可能性。一位新短暂或坚持的先生的存在能被脚趾估计很好。TTE 和脚趾,开始在于为柱子 TAVI 评估的基本考试。在 transcatheter 心阀门失败的情况下, MSCT 能被用作另外的成像技术。 | Emmanouil Chourdakis Ioanna Koniari Nicholas G Kourlis Dimitrios Velissaris Nikolaos Koutsogiannis Grigorios Tsigkas Karl Eugen Hauptmann Bruno Sontag George Hahalis | 2018 | Journal of Geriatric Cardiology2018，15，1： | 4 |
| 7 | After Administration of Intravenous Epinephrine for bee Sting-induced Anaphylaxis: Kounis Syndrome or Epinephrine Effect?显示文摘To the Editor: In the very important report published in Chinese Medical Journal,[1] a 50-year-old male patient, stented with a bare metal stent followed by 3 overlapping drug-eluting stents, developed anaphylactic reaction following a bee sting that was treated with intravenous 0.1 mg epinephrine at a 1:100,000 together with intravenous methylprednisolone, chlorpheniramine maleate, and ranitidine.He developed, immediately after, an anterior wall myocardial infarction, and subsequent coronary arteriography revealed total occlusion in the proximal left anterior descending stent and 90% stenosis with tissue growth in the mid-stent.The authors concluded that the acute myocardial infarction occurred due to acute stent thrombosis caused by exogenous epinephrine administration.This report, however, raises important questions related to the cause and pathophysiology of these events. | Nicholas G Kounis George D Soufras Dimitrios Lianas Nicholas Patsouras | 2016 | Chinese Medical Journal2016，，4： | 2 |
| 8 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 9 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 10 | Field Cancerization in the Intestinal Epithelium of Patients With Crohn’s Ileocolitis显示文摘 | Susan Galandiuk Manuel Rodriguez–Justo Rosemary Jeffery Anna M. Nicholson Yong Cheng Dahmane Oukrif George Elia Simon J. Leedham Stuart A.C. McDonald Nicholas A. Wright Trevor A. Graham | 2012 | Gastroenterology2012，，4： | 2 |
| 11 | Emergence, development, and future of cardio-oncology in China: cardiohypersensitivity, cardiotoxicity and the Kounis syndrome显示文摘To the Editor:Cancer and cardiovascular disease constitute the two major causes of death worldwide. Whereas the incidence of cancer increases among adults up to 74 years of age, above this age the cardiovascular disease surpasses cancer as the primary cause of mortality.[1] Currently, chemotherapy, radiation therapy, and surgery are the main modalities for the treatment of cancer. However, chemotherapy can induce cardiovascular worsening, manifesting as acute and chronic symptomatology. Therefore, the verv interesting report published in Chinese Medical Journal[2] concerning a 60-year-old male patient suffering from coronary artery disease and squamous cell carcinoma of the left lung who developed an ST segment elevation myocardial infarction following treatment with afatinib (tyrosine kinase inhibitor) and gemcitabine (antimetabolite pyrimidine antagonist) and cisplatin (platinum based DNA replication inhibitor) and the subsequent discussion raise several important considerations on cardiac toxicity, cardiac hypersensitivity and the Kounis-hypersensitivity acute coronary syndrome. | Nicholas G. Kounis Ioanna Koniari Panagiotis Plotas George D. Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2019 | Chinese Medical Journal2019，，6： | 2 |
| 12 | Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) supports adhesion and migration of mesenchymal stem cells and tenocytes显示文摘AIM: To establish the potential of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) as a material for tendon repair. METHODS: The biocompatibility of PHBHHx with both rat tenocytes (rT) and human mesenchymal stem cells (hMSC) was explored by monitoring adhesive characteristics on films of varying weight/volume ratios coupled to a culture atmosphere of either 21% O2 (air) or 2% O2 (physiological normoxia). The diameter and stiffness of PHBHHx films was established using optical coherence tomography and mechanical testing, respectively. RESULTS: Film thickness correlated directly with weight/volume PHBHHx (r2 = 0.9473) ranging from 0.1 mm (0.8% weight/volume) to 0.19 mm (2.4% weight/volume). Film stiffness on the other hand displayed a biphasic response which increased rapidly at values > 1.6% weight/volume. Optimal cell attachment of rT required films of ≥ 1.6% and ≥ 2.0% weight/volume PHBHHx in 2% O2 and 21% O2 respectively. A qualitative adhesion increase was noted for hMSC in films ≥ 1.2% weight/volume, becoming significant at 2% weight/volume in 2% O2. An increase in cell adhesion was also noted with ≥ 2% weight/volume PHBHHx in 21% O2. Cell migration into films was not observed. CONCLUSION: This evaluation demonstrates that PHBHHx is a suitable polymer for future cell/polymer replacement strategies in tendon repair. | Alex J Lomas George GQ Chen Alicia J El Haj Nicholas R Forsyth | 2012 | World Journal of Stem Cells2012，4，9： | 2 |
| 13 | Kounis syndrome caused by double allergens: the more allergens present, the easier, the quicker, and the more severe the anaphylaxis显示文摘To the Editor:In the very interesting report published in the Chinese Medical Journal,[1] a 42-year-old Chinese male patient who had not any previous history of cardiovascular disease,but only bee stings without any sequelae,was stung again while was cycling outdoors. | Nicholas G.Kounis Ioanna Koniari Panagiotis Plotas George D.Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2020 | Chinese Medical Journal2020，，15： | 2 |
| 14 | Analysis of Gene Expression Patterns during Seed Coat Development in Arabidopsis显示文摘种子上衣为胚胎保护,种子水和,和疏开是重要的。种子上衣作文也农业部门感兴趣,自从它同样地为人和家畜影响营养的价值。尽管一些种子上衣基因被识别了,控制种子上衣开发的发展小径完全没被阐明,并且一个全球基因程序与种子上衣开发联系了没被报导。这研究使用联合基因并且 genomic 在 Arabidopsis thaliana 来临开始到地址这些知识差距。种子上衣开发是小卵的覆盖物区分进专业化房间类型的一个复杂过程。在 Arabidopsis,房间的最外面的层分泌粘液进 apoplast 并且开发作为小柱知道的一面第二等的房间墙。在外皮下面的层,栅,综合它的内部正切的方面上的一面第二等的房间墙。最深处的层(pigmented 层或内皮细胞层) 生产 proanthocyanidins 压缩进丹宁并且氧化,给一种棕色的颜色成熟播种。这些房间层的基因分离用 ap2-7 和 tt16-1 异种被完成,在外皮 / 栅和内皮细胞层不分别地发展的地方。这基因脱离被利用由在开发期间在关键转变孤立并且收集并且执行全球基因表达式分析种子上衣检验这些房间类型的发展程序。数据显示外皮和 pigmented 层的发展节目独立地相对继续。能被用于种子上衣开发的新基因候选人的鉴定的全球表达式数据集被产生。这些数据集为在 Arabidopsis 开发种子上衣提供全面表达式侧面,并且应该为另外的种子系统提供一个有用资源和引用。 | Gillian Dean YongGuo Cao DaoQuan Xiang Nicholas J. Provart Larissa Ramsay Abdul Ahad Rick White Gopalan Selvaraj Raju Datla George Haughn | 2011 | Molecular Plant2011，4，6： | 2 |
| 15 | Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome显示文摘 | Nicholas G Kounis Ioanna Koniari Emmanouil Chourdakis George D Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2018 | Chinese Medical Journal2018，，19： | 2 |
| 16 | Field persistence studies on pendimethalin residues in onions and soil after herbicide postemergence application in onion cultivation 显示文摘 | Nicholas G Tsiropoulos George E | 1998 | J Agric Food Chem1998，46，： | 1 |
| 17 | Laparoscopic right hepatectomy: Surgical technique显示文摘 | Nicholas O’Rourke F.R.A.C.S. George Fielding F.R.C.S. F.R.A.C.S | 2004 | Journal of Gastrointestinal Surgery2004，，2： | 1 |
| 18 | Hydrodynamic computational modelling and simulations of collisional shock waves in gas jet targets显示文摘We study the optimization of collisionless shock acceleration of ions based on hydrodynamic modelling and simulations of collisional shock waves in gaseous targets.The models correspond to the specifications required for experiments with the CO2 laser at the Accelerator Test Facility at Brookhaven National Laboratory and the Vulcan Petawatt system at Rutherford Appleton Laboratory.In both cases,a laser prepulse is simulated to interact with hydrogen gas jet targets.It is demonstrated that by controlling the pulse energy,the deposition position and the backing pressure,a blast wave suitable for generating nearly monoenergetic ion beams can be formed.Depending on the energy absorbed and the deposition position,an optimal temporal window can be determined for the acceleration considering both the necessary overdense state of plasma and the required short scale lengths for monoenergetic ion beam production. | Stylianos Passalidis Oliver CEttlinger George SHicks Nicholas PDover Zulfikar Najmudin Emmanouil PBenis Evaggelos Kaselouris Nektarios APapadogiannis Michael Tatarakis Vasilis Dimitriou | 2020 | High Power Laser Science and Engineering2020，8，1： | 1 |
| 19 | 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease显示文摘 | Loren F. Hiratzka George L. Bakris Joshua A. Beckman Robert M. Bersin Vincent F. Carr Donald E. Casey Kim A. Eagle Luke K. Hermann Eric M. Isselbacher Ella A. Kazerooni Nicholas T. Kouchoukos Bruce W. Lytle Dianna M. Milewicz David L. Reich Souvik Sen Jul | 2010 | Journal of the American College of Cardiology2010，，14： | 1 |
| 20 | Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix显示文摘 | Stephen F Badylak Kinam Park Nicholas Peppas George McCabe Mervin Yoder | 2001 | Experimental Hematology2001，，： | 1 |
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