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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | Effcieney of boundary evaluation for a cellular model显示文摘 | Bidarra R Madeira J Neels W | 2005 | Computer- Aided Design2005，37，12： | 1 |
| 4 | Solubilization and purification of enzymatically active glutathione S - transferase ( pGEX ) fusion protein显示文摘 | FRANGIONI J V NEEL B G | 1993 | Anal Biochem1993，210，1： | 1 |
| 5 | Cytology of bone marrow显示文摘 | Grindem C B Neel J A Juopperi T A | | 0，，： | 1 |
| 6 | Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation 显示文摘 | Bruecher-Encke B Griffin J Neel B | 2001 | Leukemia2001，15，9： | 1 |
| 7 | Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems 显示文摘 | McLean K J Dunford A J Neel R | 2007 | Arch Biochem Biophys2007，464，2： | 1 |
| 8 | Mdm2: Keeping p53 under control显示文摘 | Pietel J Neel H Marechol V | 1997 | Oncogene1997，15，： | 1 |
| 9 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 10 | Increased expression of epider- mal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epider- mal growth factor-mediated signal transduetion pathways 显示文摘 | Habib AA Chun S J Neel BG | 2003 | Mol Cancer Res2003，1，3： | 1 |
| 11 | Innovation and business performance: a literature review 显示文摘 | Neel A Hii J | 1998 | Judge Institute of Management Studies1998，，： | 1 |
| 12 | Efficiency of boundary evaluation for a cellular model显示文摘 | Bidarra g Madeira J Neels W J | 2005 | Computer Aided Design2005，37，12： | 1 |
| 13 | High prevalence of methicillin resistant Staphylococcus aureusin pigs显示文摘 | De Neeling A J Van den Broek M J M Spalburg E C | 2007 | Vet Microbiol2007，122，： | 1 |
| 14 | Randomized study of two different target levels of glyce mic control with the all possible range in type Ⅱ diabetes 显示文摘 | Van der Does FE E kostense PJ de Neeling J ND | 1998 | Diabetes Care1998，21，12： | 1 |
| 15 | Electric fieldsuppression of epileptiform activity in hippocampal slices显示文摘 | Gluckman B J Neel E J Netoff T I | 1996 | Journal of Neurophysiology1996，76，6： | 1 |
| 16 | Macrophage polarization: the epigcnetic point of view显示文摘 | Van den Bossche J Neele A E Hoeksema M A | 2014 | Curt' Opin Lipidol2014，25，5： | 1 |
| 17 | Using game theory to analyze wireless ad hoc networks显示文摘 | Srivastava V Neel J O MacKenzie A B | 2015 | IEEE Communications Surveys and Tutorials2015，7，14： | 1 |
| 18 | Efficiency of boundary evaluation for a cellular model 显示文摘 | Bidarra R Bronsvoort W F Neels W J | 2005 | Computer-Aided Design2005，37，12： | 1 |
| 19 | Early glottic carcinoma treated with open laryngeal procedures 显示文摘 | Thomas J V Olsen K D Neel H B | 1994 | Arch Otolaryngol Head Neck Surg1994，120，： | 1 |
| 20 | A gene(ETM)for essential tremor maps to chromosome ZP 22-P25显示文摘 | HIGGINS J J PHOLT NEELE | 1997 | Mov D isord1997，12，6： | 1 |
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