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| 1 | Review of the current targeted therapies for non-small-cell lung cancer显示文摘The last decade has witnessed the development of oncogene-directed targeted therapies that have significantly changed the treatment of non-small-cell lung cancer(NSCLC). In this paper we review the data demonstrating efficacy of gefitinib, erlotinib, and afatinib, which target the epidermal growth factor receptor(EGFR), and crizotinib which targets anaplastic lymphoma kinase(ALK). We discuss the challenge of acquired resistance to these small-molecular tyrosine kinase inhibitors and review promising agents which may overcome resistance, including the EGFR T790 Mtargeted agents CO-1686 and AZD9291, and the ALKtargeted agents ceritinib(LDK378), AP26113, alectinib(CH/RO5424802), and others. Emerging therapies directed against other driver oncogenes in NSCLC including ROS1, HER2, and BRAF are covered as well. The identification of specific molecular targets in a significant fraction of NSCLC has led to the personalized deployment of many effective targeted therapies, with more to come. | Kim-Son H Nguyen Joel W Neal Heather Wakelee | 2014 | World Journal of Clinical Oncology2014，5，4： | 13 |
| 2 | Impact of the suction line accumulator on the frost/defrost performance of an air-source heat pump with a scroll compressor显示文摘 | Nutter D W O'Neal D L Payne W V | 1996 | ASHRAE Transaction1996，102，1： | 4 |
| 3 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 4 | Effect of planar anisotropy on wrinkle formation tendencies in curved sheets 显示文摘 | TUGCUA P NEALE K W | 2001 | International Journal of Mechanical Sciences2001，43，3： | 2 |
| 5 | On pre-straining and the evolution of material anisotropy in sheet metals显示文摘 | WU P D MACEWEN S R LLOYD D J JAIN M TUGCU P NEALE K W | 2005 | Int J Plasticity2005，21，： | 1 |
| 6 | Catchment-scale advection and dispersion as a mechanism for fractal scaling in stream tracer concentrations显示文摘 | Kirchner J W Feng X H Neal C | 2001 | Journal of hydrology2001，254，： | 1 |
| 7 | Di- verse groups and information sharing: The effect of congruent ties显示文摘 | Williams K W Mannix E A Neale M A | 2004 | Journal of Experimental Social Psy- chology2004，40，4： | 1 |
| 8 | The habitual consumer显示文摘 | Wood W Neal D T | 2009 | Journal of Consumer Psychology2009，19，4： | 1 |
| 9 | Fiber-reinforced Polymer-confined Circular Concrete Columns: Investigation of Size and Slenderness Effects 显示文摘 | Theriault M Neale K W Claude S | 2004 | Journal of Composite for Construction2004，4，323： | 1 |
| 10 | Experimental investigation of bonded fiber reinforced polymer-concrete joints under cyclic loading 显示文摘 | Bizindavyi L Neale K W Erki M A | 2003 | Journal of Composites for Construction2003，7，2： | 1 |
| 11 | Development status of the VOXSO-combined NOx/SO2 flue gas treatment process显示文摘 | J L Haslbeck L G Neal W T Ma | 1998 | Integrated Environmental Control1998，，3： | 1 |
| 12 | Development of an Effective Palladium Removal Process for VEGF Oncology Candidate AG13736 and a Simple,Efficient Screening Technique for Scavenger Reagent Identification显示文摘 | ERIK J F BRIGITTE L E NEAL W S | 2008 | Organic Process Research & Development2008，，12： | 1 |
| 13 | Predictions of forming limit dia-grams using a rate-sensitive crystal plasticity model 显示文摘 | ZHOU Y NEALE K W | 1995 | Inter-national Journal of Mechanical Sciences1995，37，1： | 1 |
| 14 | Glutamine synthetase of pea leaves I Purifieation, stabilization, and pH optima 显示文摘 | O'Neal D Joy K W | 1973 | Arch Bioehem Biophys1973，，159： | 1 |
| 15 | Impact of the suction line accumulation on the frost/defrost performance of an air-source heat pump with a scroll compressor显示文摘 | Nutter D W O'Neal D L Vance W | 1990 | ASHRAE1990，96，10： | 1 |
| 16 | Mutations in an auxin receptor homolog AFB5 and in SGT1bconfer resistance to synthetic picolinate auxins and not to 2,4-D or IAA in Arabidopsis显示文摘 | WALSH T A NEAL R MERLO A O HONMA M HICKS G R WOLFF K MATSUMURA W DAVIES J P | 2006 | Plant Physiology2006，142，： | 1 |
| 17 | Practical significance of Brinkman's extension of Darcy's law: coupled parallel flows within a channel and a bounding porous medium显示文摘 | Neale G Nader W | 1974 | The Canadian Journal of Chemical Engineering1974，52，： | 1 |
| 18 | Thermal interference of adjacent legs in a vertical U-tube heat exchanger for a ground- coupled heat pump 显示文摘 | N K Muraya D L O Neal W M Heffington | 1996 | ASHRAE Transactions1996，102，2： | 1 |
| 19 | Impact of the suction line accumulator on the frost/defrost performance of an air-source heat pump with a scroll compressor显示文摘 | Nutter D W O'Neal D L Payne W V | 1993 | ASHRAE Transaction1993，99，1： | 1 |
| 20 | Predictions of forming limit diagrams using a rate-sensitive crystal plasticity model 显示文摘 | Zhou Y Neale K W | 1995 | IntJ MechSci1995，37，： | 1 |
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