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| 1 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 2 | Inhibition of smoothened decreases proliferation of Synoviocytes in rheumatoid arthritis显示文摘像成纤维细胞的 synoviocytes (FLS ) 在风湿性关节炎(RA ) 贡献 synovial 增生。Smoothened (Smo ) 是发信号的声音的刺猬(嘘) 的一个关键部件并且贡献肿瘤房间增长。这研究的目的是在 RA synoviocyte 增长调查 Smo 的角色。FLS 从 RA synovium 被孤立。发信号的嘘用一个 Smo 对手(GDC-0449 ) 和在 FLS 指向 Smo 基因的小介入 RNA (siRNA ) 被学习。房间增长被使用 kit-8 试金和房间周期分发确定, apoptosis 被流动 cytometry 评估。房间周期相关的基因和蛋白质被即时 PCR 和西方的污点检测。与 GDC-0449 或 Smo-siRNA 对待的 FLS 与控制相比显示出显著地减少的增长(P < 0.05 ) 。有 GDC-0449 的孵化或有 Smo-siRNA 的 transfection 与控制相比导致了 G 1 阶段房间的重要增加(P < 0.05 ) 。房间周期拘捕被 cyclin D1 和 E1 mRNA 表示的重要增加验证,在在 Smo-siRNA transfected 房间的 cyclin 依赖的 kinase p21 mRNA 表示的减少(P < 0.05 ) 。cyclin D1 的蛋白质表示也是在 Smo 基因以后的 downregulated 击倒(P < 0.05 ) 。结果建议发信号的嘘以一种 Smo 依赖的方式在 RA-FLSs 增长起一个重要作用并且可以贡献 synovial 增生。指向嘘发信号可以帮助与 RA 在病人控制联合损坏。 | Shang-ling Zhu Jian-lin Huang Wei-xiang Peng Dan-chun Wu Min-qi Luo Qiu-xia Li Zhao-xia Li Xiao-xue Feng Fang Liu Ming-xia Wang Wei-qian Chen Nancy Olsen Song Guo Zheng | 2017 | Cellular & Molecular Immunology2017，14，2： | 9 |
| 3 | CD69 expression on airway eosinophils and airway inflammation in a murine model of asthma显示文摘Background Asthma is a chronic airway disease with inflammation characterized by physiological changes (airway hyper-responsiveness, AHR) and pathological changes (inflammatory cells infiltration and mucus production). Eosinophils play a key role in the allergic inflammation. But the causative relationship between eosinophils and airway inflammation is hard to prove. One of the reasons is lack of activation marker of murine eosinophils. We investigated the expression of CD69 on murine eosinophils in vitro, the relationship between the expression of CD69 on eosinophils from peripheral blood and bronchoalveolar lavage fluid and on airway inflammation in asthmatic mice. Methods Eosinophils from peripheral blood of IL-5 transgenic mice (NJ.1638) were purified. Mice were divided into five groups: wild type mice sensitized and challenged with saline (WS group), wild type mice sensitized and challenged with ovalbumin (WO group), IL-5-/- mice sensitized and challenged with saline and transferred with purified eosinophils (ISE group), IL-5-/- mice sensitized and challenged with OVA and transferred with purified eosinophils (IOE group), IL-5-/- mice sensitized and challenged with OVA and transferred with purified eosinophils, pretreated with anti CD4 monoclonal antibody (IOE+antiCD4mAb group). IL-5-/- mice were sensitized with OVA at day 0 and day 14, then challenged with OVA aerosol. On days 24, 25, 26 and 27 purified eosinophils were transferred intratracheally to IL-5-/- mice. On day 28, blood and BALF were collected and CD69 expression on eosinophils measured by flowcytometry. Results Purified eosinophils did not express CD69. But eosinophils cultured with PMA+MA, IFN-γ, IL-5 or GM-CSF expressed CD69 strongly. Eosinophils from blood of WO, WS group did not express CD69 at all. The numbers of eosinophils in BALF of WO group, IOE group, ISE group and IOE+antiCD4mAb group were significantly higher than in mice of WS group which did not have eosinophils at all. CD69 expression on eosinophils in BALF of IOE and WO groups was strong. Eosinophils in BALF of ISE and IOE+antiCDmAb groups did not express CD69. The mucus production result was similar to CD69 expression. There were eosinophils infiltration in lung slides of all groups except WS group. Conclusion Activation in airway of eosinophils could directly lead to airway inflammation. | WANG Hui-ying SHEN Hua-hao James J Lee Nancy A Lee | 2006 | Chinese Medical Journal2006，，23： | 8 |
| 4 | Connecting scales: Achieving in-field pest control from areawide and landscape ecology studies显示文摘Areawide 管理有完成然而,在那里指向害虫的答案的长历史是节肢动物天赋敌人的 areawide 管理的小焦点。显示出在生来的敌人丰富和产地差异之间的一种积极关系的风景生态学研究表明风景依赖者害虫抑制,但是还没有清楚地连接了他们的调查结果到害虫管理或到与要求控制的庄稼联系的害虫的套房。相反焦点经常在单个害虫种类和他们的生来的敌人的模型系统上。我们建议从生来的敌人捕获害虫控制的管理行动可能向前正在来如果:(i) 害虫建筑群和特定的管理行动上的反应和预言者变量焦点的套房;(ii )“the landscape” 的贡献被估计预定和生来的敌人移民并且移民到并且从目标庄稼,以及害虫的数字识别;并且(iii ) 与庄稼发展阶段排列的害虫控制阀值是基准在害虫上测量生来的敌人的影响,接着允许在学习区域之间的比较,和归纳。为了完成害虫控制,我们将需要合并什么从模型害虫和生来的敌人系统的生态的理解被学习了并且与内场害虫管理集成 areawide 风景管理。 | Nancy A. Schellhorn Hazel R. Parry Sarina Macfadyen Yongmo Wang Myron P. Zalucki | 2015 | Insect Science2015，22，1： | 6 |
| 5 | High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways显示文摘The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary habits.Since sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including SLE.Given the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE model.We used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient mice.We observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC activation.NaCl treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in vitro.Pretreatment of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced lupus.These mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal lesions.The p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune activities.Taken together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of SLE.Thus,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases. | Ze Xiu Xiao Xiaojiang Hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao Baoqing Sun Joseph A.Bellanti Nancy Olsen Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 6 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 7 | TGF-β-induced CD4+FoxP3+regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model显示文摘CD4^(+)FOXP3^(+)Treg cells are central to the maintenance of self-tolerance and can be defective in autoimmunity.In autoimmune rheumatic diseases,dysfunctional self-tolerance,is to a large extent,caused by insufficient Treg-cell activity.Although nTregs have therapeutic effects in vivo,their relative scarcity and slow rate of in vitro expansion hinder the application of nTreg therapy.It was previously reported that EVs contribute significantly to the suppressive function of FOXP3^(+)Treg cells.Considering that the stability and plasticity of nTregs remain major challenges in vivo,we established EVs derived from in vitro TGF-β-induced Treg cells(iTreg-EVs)and assessed their functions in a murine model of autoimmune arthritis.The results demonstrated that iTreg-EVs preferentially homed to the pathological joint and efficiently prevented the imbalance in Th17/Treg cells in arthritic mice.Furthermore,we found that miR-449a-5p mediated Notch1 expression modulation and that miR-449a-5p knockdown abolished the effects of iTreg-EVs on effector T cells and regulatory T cells in vitro and in vivo.Taken together,our results show that iTreg-EVs control the inflammatory responses of recipient T cells through miR-449a-5p-dependent modulation of Notch1 and ameliorate the development and severity of arthritis,which may provide a potential cell-free strategy based on manipulating iTreg-EVs to prevent autoimmune arthritis. | Jingrong Chen Feng Huang Yuluan Hou Xiaorong Lin Rongzhen Liang Xiaojiang Hu Jun Zhao Julie Wang Nancy Olsen Song Guo Zheng | 2021 | Cellular & Molecular Immunology2021，18，11： | 2 |
| 8 | Estimating the risk of collisions between bicycles and motor vehicles at signalized intersections 显示文摘 | Wang Yinhaia Nihan Nancy L | 2004 | Accident Analysis and Preventian2004，36，5： | 1 |
| 9 | Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Predictor of Outcome in Head-and-Neck Squamous Cell Carcinoma Patients With Nodal Metastases显示文摘 | Amita Shukla-Dave Nancy Y. Lee Jacobus F.A. Jansen Howard T. Thaler Hilda E. Stambuk Matthew G. Fury Snehal G. Patel Andre L. Moreira Eric Sherman Sasan Karimi Ya Wang Dennis Kraus Jatin P. Shah David G. Pfister Jason A. Koutcher | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 10 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 1 |
| 11 | Achieving eugastrinemia in MEN1 patients: Both duodenal inspection and formal lymph node dissection are important显示文摘 | Paxton V. Dickson Thereasa A. Rich Yan Xing Gilbert J. Cote Huamin Wang Nancy D. Perrier Douglas B. Evans Jeffrey E. Lee Elizabeth G. Grubbs | 2011 | Surgery2011，，6： | 1 |
| 12 | Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation显示文摘 | Wang H Y Li W W Nancy J | | 0，，34： | 1 |
| 13 | Isolation and Characterization of Circulating Tumor Cells in Patients with Metastatic Colorectal Cancer显示文摘 | Steven J. Cohen R. Katherine Alpaugh Steve Gross Shawn M. O’Hara Denis A. Smirnov Leon W.M.M. Terstappen W. Jeffrey Allard Maryann Bilbee Jonathan D. Cheng John P. Hoffman Nancy L. Lewis Ann Pellegrino André Rogatko Elin Sigurdson Hao Wang James C. Watson | 2006 | Clinical Colorectal Cancer2006，，2： | 1 |
| 14 | Clinical correlation needed: What do emergency physicians do after an equivocal ultrasound for pediatric acute appendicitis?显示文摘 | Naresh Ramarajan Rajesh Krishnamoorthi Laleh Gharahbaghian Elizabeth Pirrotta Richard A. Barth Nancy E. Wang | 2014 | J. Clin. Ultrasound2014，，： | 1 |
| 15 | The co-movement of stock markets in East Asia did the 1997-显示文摘 | Nancy Huyghebaert Lihong Wang | 2010 | China Economic Review2010，，21： | 1 |
| 16 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 1 |
| 17 | G protein β3 subunit variant and essential hypertension in Taiwan — a case–control study显示文摘 | Cheng-Ho Tsai Hung-I Yeh Yusan Chou Hsin-Fu Liu Tzu-Yao Yang Jyh-Chwan Wang Nancy M. Wang Jan-Gowth Chang | 2000 | International Journal of Cardiology2000，，2： | 1 |
| 18 | Toll-like receptors in inflammation, infection and cancer显示文摘 | Keqiang Chen Jian Huang Wanghua Gong Pablo Iribarren Nancy M. Dunlop Ji Ming Wang | 2007 | International Immunopharmacology2007，，10： | 1 |
| 19 | Trends in Acute Myocardial Infarction in Young Patients and Differences by Sex and Race, 2001 to 2010显示文摘 | Aakriti Gupta Yongfei Wang John A. Spertus Mary Geda Nancy Lorenze Chileshe Nkonde-Price Gail D’Onofrio Judith H. Lichtman Harlan M. Krumholz | 2014 | Journal of the American College of Cardiology2014，，： | 1 |
| 20 | Lack of Commensal Flora in Helicobacter pylori –Infected INS-GAS Mice Reduces Gastritis and Delays Intraepithelial Neoplasia显示文摘 | Jennifer L. Lofgren Mark T. Whary Zhongming Ge Sureshkumar Muthupalani Nancy S. Taylor Melissa Mobley Amanda Potter Andrea Varro Daniel Eibach Sebastian Suerbaum Timothy C. Wang James G. Fox | 2011 | Gastroenterology2011，，1： | 1 |
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