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139篇 您的检索式：作者名="NOSKE"

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	题名	作者	年代	出处	被引量
1	Polo-like kinase 1 expression is a prognostic factor in human colon cancer显示文摘AIM: To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1(PLK1) in colon cancer.METHODS: Expression of PLK1 was investigated by immunohistochemistry (158 cases) and immunoblotting in tissue of colon adenomas and adenocarcinomas. PLK1expression patterns were correlated with clinicopathological parameters and patient prognosis. In addition, expression of PLK1 was evaluated by immunoblot and PCR in colon carcinoma cell lines, and coexpression of PLK1 with the proliferation marker Ki-67 was investigated.RESULTS: Weak PLK1 expression was observed in normal colon mucosa and adenomas. In contrast, 66.7% of carcinomas showed strong expression of PLK1.Overexpression of PLK1 correlated positively with Dukes stage (P<0.001), tumor stage (P = 0.001) and nodal status (P<0.05). Additionally, PLK1 expression was a prognostic marker in univariate survival analysis (P<0.01) and had independent prognostic significance (RR = 3.3, P = 0.02)in patients with locoregional disease. Expression of PLK1 mRNA and protein was detected in all cell lines investigated. Coexpression of PLK1 and Ki-67 was observed in the majority of colon cancer cells, but a considerable proportion of cells showed PLK1 positivity without Ki-67expression.CONCLUSION: PLK1 is a new prognostic marker for colon carcinoma patients and may be involved in tumorigenesis and progression of colon cancer. Strategies focusing on PLK1 inhibition in vivo might therefore represent a promising new therapeutic approach for this tumor entity.	Wilko Weichert Glen Kristiansen Mathias Schmidt Volker Gekeler Aurelia Noske Silvia Niesporek Manfred Dietel Carsten Denkert	2005	World Journal of Gastroenterology2005，11，36：	16
2	Genome-wide gene expression profiling of formalin-fixed paraffin-embedded breast cancer core biopsies using microarrays 显示文摘	Budczies J Weichert W Noske A	2011	J Histochem Cytochem2011，59，2：	1
3	Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis显示文摘	Noske A LindenbergJL Darb-Esfahani S	2008	On col Rep2008，20，6：	1
4	Transpedicular wedge resection osteotomy for the treatment of a kyphotic Andersson lesion complicating ankylosing spondylitis 显示文摘	Van Royen BJ Kastelijns RC Noske DP etal	2006	Eur Spine J2006，15，2：	1
5	Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State显示文摘	Wenjun Guo Zuzana Keckesova Joana Liu Donaher Tsukasa Shibue Verena Tischler Ferenc Reinhardt Shalev Itzkovitz Aurelia Noske Ursina Zürrer-H?rdi George Bell Wai Leong Tam Sendurai A. Mani Alexander van Oudenaarden Robert A. Weinberg	2012	Cell2012，，5：	1
6	Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer 显示文摘	Denkert C Loibl S Noske A	2010	J Clin Oneol2010，28，1：	1
7	Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation:increased expression of AKT in advanced ovarian cancer显示文摘	Kaszubiak A Weichert W	2007	Cancer Lett2007，246，12：	1
8	Machine Tool Monitoring Applied to Lathe Chucks显示文摘	Tnshoff H K Noske H	1990	Annals of the CIRP1990，39，1：	1
9	Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer显示文摘	Noske A Kaszubiak A Weichert W	2007	Cancer Lett2007，246，12：	1
10	Expression of the nu-clear export protein chromosomal region maintenance/ex-portin 1/Xpo1 is a prognostic factor in human ovarian can-cer显示文摘	Noske A Weichert W Niesporek S	2008	Cancer2008，112，8：	1
11	Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer显示文摘	Denkert C Loibl S Noske A		0，，01：	1
12	Specific inhibition of AKT2 by RNA interference results in reduction of ovarian can- cer cell proliferation:increased expression of AKT in advanced ovarian cancer 显示文摘	Noske A Kaszubiak A Weichert W	2007	Cancer Letters2007，246，12：	1
13	C,enome-wide gene expression profiling of formalin-fixed paraffin-embedded breast cancer core biopsies using microarrays显示文摘	Budczies J Weichert W Noske A		0，，02：	1
14	Specific inhibition of AKT2 by RNA Interfeemce resμLts in reduction of ovarian cancer cell proliferation:Increased expression of AKT in advanced ovarian cancer显示文摘	Noske A Kaszubiak A Weichert W	2006	Concer Lea2006，235，1：	1
15	Historical milestones regarding torsion of the scrotal organs 显示文摘	Noske HD Kraus SW Altinkilic BM Weidner W	1998	J Urol1998，159，1：	1
16	Cerebral microdialysis and positron emission tomography after surgery for aneurysmal subarachnoid hemorrhage in grade Ⅰ patients 显示文摘	Noske DP Peerdeman SM Comans EF	2005	Surg Neurol2005，64，2：	1
17	Expression of class I his- tone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas 显示文摘	Weichert W Denkert C Noske A	2008	Neoplasia2008，10，9：	1
18	Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation:increased expression of AKT in advanced ovarian cancer显示文摘	Kaszubiak A Weiehert W	2007	Cancer Lett2007，246，12：	1
19	An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian careinomas显示文摘	Noske A Schwabe M Weichert W	2011	BMC Caneer2011，11，1：	1
20	ARID1A mutations and PI3K/AKT pathway alterations in endometriosis and endometriosis- associated ovarian carcinomas 显示文摘	Samartzis EP Noske A Dedes KJ	2013	Int J Mol Sci2013，14，18：	1

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