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| 1 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 2 | Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants显示文摘 | Nikolai V K Irina A R Natalia A I | 2002 | J Gen Virol2002，83，： | 1 |
| 3 | Epitope mapping of the hemagglutinin molecule of a highly pathogenic HSN1 influenza virus by using monoclonal antibodies显示文摘 | Nikolai V K Irina A R Elena A G | 2007 | J Virol2007，81，12： | 1 |
| 4 | Synthesis and reactions of 1,1-diamino-2,2-dinitroethylene显示文摘 | Nikolai V Latypov Jan Bergman | 1998 | Tetrahe-dron1998，，11： | 1 |
| 5 | J Phys Chem B显示文摘 | Nikolai Gaponik Talapin D V Rogach A L | 2002 | 106:7 1772002，106，： | 1 |
| 6 | Structure of anti- gen-ic sites on the haemagglutinin molecule of H5 avian influen- za v-irus and phenotypic variation of escape mutants 显示文摘 | Nikolai V K Irina A R Natalia A I | 2002 | J Gen Virol2002，83，： | 1 |
| 7 | Computing Currency Invariant Indices with an Application to Minimum Variance Currency Baskets显示文摘 | Nikolai V Hovanov James W Kolari | 2004 | Journal of Economic Dynamics and Control2004，28，： | 1 |
| 8 | Effect of Technological Factors on Strip Profile in Twin-Roll Casting Process显示文摘 | Nikolai Z Mihail V | 1998 | ISIJ International1998，38，10： | 1 |
| 9 | Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypie variation of escape mutants 显示文摘 | Nikolai V Kaverin Irina A | 2002 | Journal of General Virology2002，83，： | 1 |
| 10 | Construction of long DNA molecules using long PCR-based fusion of several fragments simultaneously显示文摘 | Nikolai A S Anton V B Yevgeniya A N | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 11 | Copulas : A Review and Recent Developments 显示文摘 | Mendes B V M Kolev Nikolai Anjos U | 2006 | Stochastic Models2006，22，4： | 1 |
| 12 | Network control with delay measurement and estimation显示文摘 | Nikolai V Jean-Philippe G Christophe A | 2008 | Control Engineering Practice2008，17，2： | 1 |
| 13 | Design and Syn- thesis of Highly Photostable Fluorescence Sensing 1, 8-Naph- thalimide-Based Dyes Containing s-Triazine UV Absorber and HALSUnits显示文摘 | Vladimir B B Nikolai I G Nevena V M | 2010 | SensActuators B2010，148，1： | 1 |
| 14 | Effective medium theories for irregular structures: Aggregation of small particles显示文摘 | NIKOLAI V V GORDEN V THOMAS H | 2007 | Applied Optics2007，46，19： | 1 |
| 15 | Construction of long DNA molecules using long PCR based fusion of several fragments simultaneously 显示文摘 | Nikolai A S Anton V B Yevgeniya A N | 2004 | Nuc- leic Acids Researsh2004，32，2： | 1 |
| 16 | Purification of zinc sulfate solutions from cobalt and nickel through activated cementation显示文摘 | Boyan S B Victoria V K Nikolai K K | 2004 | Hydrometallurgy2004，73，2： | 1 |
| 17 | Inclusion com-plexes of carotenoids with cyclodextrin's 1H NMR,EPR and optical Studies显示文摘 | Nikolai E Polyako V Tatyana V | 2004 | Free Radical Biology&Medicine2004，36，7： | 1 |
| 18 | Copulas: A Review and Recent Developments 显示文摘 | MENDES B V M NIKOLAI K ANJOS U | 2006 | Stochastic Models2006，22，4： | 1 |
| 19 | Kinetics of aerobic liquid phase oxidation of organic compounds显示文摘 | Tatiana V Bukharkina Nikolai G Digurov | 2004 | Organic Process Research & Development2004，8，： | 1 |
| 20 | Anterior cervical fusion with the Orion locking plate system显示文摘 | Heidecke V Nikolai G Burkert W | 1998 | Spine1998，23，16： | 1 |
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