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| 1 | Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy显示文摘AIM: To reviewing genetic and epigenetic make-up of metastatic colorectal cancers(m CRCs) addicted to epidermal growth factor receptor(EGFR) signalling.METHODS: The present study summarizes the potential value of prognostic and predictive biomarkers in selecting m CRC patients treated with anti-EGFR therapy. A meta-analysis was performed using a systematic search of Pub Med, Medline and Web of Science to identify eligible papers until March 21 st, 2016 using these following terms: ‘‘colorectal cancer'', 'predictive biomarkers' ', 'anti-EGFR therapy', 'KRAS', 'NRAS'', 'PIK3CA', 'TP53', 'PTEN', ‘‘EGFR', 'MET', 'HER2', 'epiregulin', 'amphiregulin', 'prognostic biomarkers', 'BRAF', 'miR NA' and 'antibody-dependent cell-mediated cytotoxicity(ADCC) activity'. Two investigators independently evaluated and extracted data from each identified studies based on selected criteria of inclusion and exclusion. RESULTS: The introduction of agents targeting EGFR such as cetuximab and panitumumab increased overall survival of mC RCs. Nevertheless, it has firstly became evident that response rates to cetuximab regimens in unselected patient populations were typically lower than 30%. Clinical data confirmed the predictive value of RAS mutations for resistance to cetuximab and panitumumab leading to the license of these monoclonal antibodies exclusively for the management of patients with RAS-wild type colorectal cancers. So far the identification of predictive biomarkers have generated interesting, though preliminary and, at times, conflicting data on the importance of tumour mR NA levels of EGFR ligands, of activating mutations in other genes such as NRAS and PIK3 CA. The prognostic value of selected micro RNAs level and ADCC activity is under investigation, while the prognostic impact of BRAF status remains controversial.CONCLUSION: This review focuses on the personalized treatment of m CRC and discusses the potential of new prognostic and predictive biomarkers in selecting patients treated with anti-EGFR therapy. | Cristiana Lo Nigro Vincenzo Ricci Daniela Vivenza Cristina Granetto Teresa Fabozzi Emanuela Miraglio Marco C Merlano | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 2 | Steel and concrete composite beams with flexible shear connection: exact analytical expression of the stiffness matrix and applications 显示文摘 | FAELLA C MARTINELLI E NIGRO E | 2002 | Computers and Structures2002，30，11： | 1 |
| 3 | Identification of a DNA binding protein cooperating with estrogen receptor as RIZ(retinoblastoma interacting zinc finger protein)显示文摘 | Medici N Abbondanza C Nigro V | 1999 | Biochem Biophys Res Commun1999，264，3： | 1 |
| 4 | Mutations inGDI1 are responsible for X-linked non-specific mental retar-dation显示文摘 | D'Adamo P Menegon A Lo Nigro C | 1998 | Nat Genet1998，19，： | 1 |
| 5 | The comet assay for the evaluation of the genetic hazard of pollutants in cetaceans: preliminary results on the genotoxic effects of methyl-mercury on the bottle-nosed dolphin (Tursiops truncatus) lymphocytes in vitro显示文摘 | BETTI C NIGRO M | 1996 | Marine Pollution Bul- letin1996，32，7： | 1 |
| 6 | Role of NADPH oxidase inatherosclerosis显示文摘 | Violi F Basili S Nigro C | 2009 | Future Cardiol2009，5，1： | 1 |
| 7 | Randomized trial onthe ef- fect of sevoflurance on polypropylene membrane oxygenator perfor- mance显示文摘 | Nigro Neto C Arnoni R Rida BS | 2013 | J Cardiothorac Vasc Anesth2013，27，5： | 1 |
| 8 | Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A 显示文摘 | SATOH K NIGRO P BERK B C | 2010 | Antioxid Redox Signal2010，12，5： | 1 |
| 9 | Congenital and perinatal cytomegalovirus lung infection显示文摘 | Coclite E Di Natale C Nigro G | 2013 | J Ma- tern Fetal Neonatal Med2013，26，17： | 1 |
| 10 | Non-recurrent la- ryngeal nerve coexisting with ipsilateral recurrent nerve personal experience and literature review 显示文摘 | Geraci G Lo Nigro C Sciuto A | 2011 | G Chir2011，32，5： | 1 |
| 11 | Oxidative stress and vascular smooth muscle cell growth: A mechanistic linkage by cyclophilin A 显示文摘 | Satoh K Nigro P Berk B C | 2010 | An- tioxid Redox Signal2010，，12： | 1 |
| 12 | Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A显示文摘 | SATOH K NIGRO P BERK B C | 2010 | Antioxid Redox Signal2010，5，： | 1 |
| 13 | Ultrastructural evidence of Wolbachia Rickettsiales in Drosophila simulans and their relationships with undirectional cross-incompatibility显示文摘 | Louis C Nigro L | 1989 | Invertebrate pathology1989，54，： | 1 |
| 14 | Steel and concrete composite beams with flexible shear connection: 'exact' analytical expression of the siffness matrix and applications显示文摘 | Faella C Martinelli E Nigro E | 2002 | Comp Struct2002，80，： | 1 |
| 15 | Role of NADPH Oxidase in Atherosclerosis显示文摘 | Violi F Basili S Nigro C | 2009 | Future Cardiology2009，5，1： | 1 |
| 16 | Influence of a nanoscal gold thin layer on Ti/SnO2-Sb2O5 electrodes显示文摘 | Chen A C Nigro S | 2003 | J Phys Chem B2003，107，13： | 1 |
| 17 | Diagnosis and treatment of prostatitis in Canada显示文摘 | Nickel J C Nigro M Valiquette L | 1998 | Urology1998，52，5： | 1 |
| 18 | Ultrastructural evidence of Wolbachia Rickettsiales in Drosophila simulans and their relationships with unidirectional cross-incompatibility 显示文摘 | Nigro L | 1989 | J Invert Pathol1989，54，： | 1 |
| 19 | Role of NAI)PH oxidase ira atherosclerosis显示文摘 | Violi F Basili S Nigro C | 2009 | Future Cardiol2009，5，： | 1 |
| 20 | Ultrastructural evidence of Wolbachia rick- ettsiales in Drosophila simulans and their relationships with unidirectional cross incompatibility 显示文摘 | Louis C Nigro L | 1989 | J of Invertebrate Path1989，54，： | 1 |
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