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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | 动态增强磁共振参数分析法评价NPI-2358对肿瘤的早期抗血管作用显示文摘目的:通过分析T1加权像下动态增强磁共振(DCE-MR)参数变化,探讨新型血管阻断剂NPI-2358对肿瘤的早期抗血管疗效。方法:小鼠C3H乳腺癌模型经腹腔注射7.5mg/kgNPI-2358溶液,置于7-T波谱成像系统的动态增强磁共振内,分别采集注射前后肿瘤区域的T1图像,利用Mat-lab2008软件分析数据。结果:NPI-2358组,与处理前相比,处理后1、3和6h的半定量参数IAUC均明显降低,P均<0.05;动力学参数Ktrans,与处理前相比,处理后3h明显降低,P<0.05;对照组,处理前后差异无统计学意义。结论:NPI-2358是一类起效、恢复均较为迅速的血管阻断剂,对肿瘤有早期的抗血管疗效。 | 沈媛媛 刘成霞 Bertelsen L B Nielsen T Horsman M R Stoedkilde-Joerrgensen H | 2010 | 中华肿瘤防治杂志2010，17，7： | 2 |
| 3 | Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women显示文摘 | Mullen L M Nielsen F H Hunt C D Hunt J R | 1987 | The FASEB journal1987，，1： | 1 |
| 4 | Purification andcharacterization of an extracellular protease produced by Pseudomonas fluorescens M3/6显示文摘 | KOHLMANN K L NIELSEN S S LADISCH M R | 1991 | J Dairy Sci1991，74，： | 1 |
| 5 | Dissecting the plant transcriptome and the regulatory responses to phosphate deprivation显示文摘 | Nilsson L Muller R Nielsen T H | 2010 | Physiology Plant2010，，139： | 1 |
| 6 | Thermostable enzymes for industrial applications 显示文摘 | ZAMOST B L Nielsen H Starnes R | 1991 | Ind Microbiol1991，8，： | 1 |
| 7 | Non-invasive imaging of combretastatin ac- tivity in two tumor models: association with invasive estimates 显示文摘 | Nielsen T Murata R Maxwell R J Stedkilde-Jorgensen H Oster- gaard L Ley CD etal | 2010 | Acta Oncol2010，49，7： | 1 |
| 8 | Serological characterization of Actinobacillus pleuropneumoniae biotype 1 strains antigenically related to both serotypes 2 and 7显示文摘 | Nielsen R Andresen L O Plarnbeck T | 1996 | Acta Vet Stand1996，37，3： | 1 |
| 9 | Wheat yield estimates using multi temporal NDVI satellite imagery 显示文摘 | Labus M P Nielsen G Lawarence R L | 2002 | International Journal of Remote Sensing2002，23，20： | 1 |
| 10 | Geostatistical theory and application to variability of some agronomical properties显示文摘 | VOEORA S R HATFIELD J L NIELSEN D R | 1982 | Hilgardia1982，51，： | 1 |
| 11 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 12 | Is congo red an amyloid-specific dye?显示文摘 | KHURANA R UVERSKY V N NIELSEN L | 2001 | J Biol Chem2001，276，22： | 1 |
| 13 | Drought and aquatic community resilience:The role of eggs and seeds in sediments of temporary wetlands显示文摘 | Brock M A Nielsen D L Shiel R J | | 0，，48： | 1 |
| 14 | Antibodies against App serotype 2 in mucosal secretions and sera of affected pigs as demonstrated by an enzyme-linked immunosorbent assay显示文摘 | Laftager M K Eriksen L Nielsen R | 1993 | Res Vet Microbiol1993，54，1： | 1 |
| 15 | Experimental and Theoretical Investigation of the Impact of Ultra-fast Carrier Dynamics on High-speed SOA-based All-optical Switches显示文摘 | NIELSEN L M MORE J SUZUKI R | 2006 | Optics Express2006，14，01： | 1 |
| 16 | Psychometrically equivalent polish bisyllabicwords spoken by male and female talkers显示文摘 | HARRIS R W NIELSEN W S MCPHERSON D L | 2004 | Audiofo-nologia2004，25，： | 1 |
| 17 | SimRoot: modeling and visualization of root systems显示文摘 | Lynch J P Nielsen K L Davis R D | 1997 | Plant and Soil1997，188，： | 1 |
| 18 | Effect of plant spacing variability on corn grain yield 显示文摘 | Nielsen R L | 2006 | 2006，，： | 1 |
| 19 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 20 | Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties显示文摘 | Gudjonsson T Villadsen R Nielsen H L | 2002 | Genes Dev2002，16，6： | 1 |
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