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| 1 | Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR:A systematic literature review显示文摘AIM:To review literature on efficacy and safety of octreotide-long-acting repeatable(LAR)used at doses higher than the Food and Drug Administration(FDA)-approved 30 mg/mo for treatment of neuroendocrine tumors(NETs).METHODS:We searched Pub Med and Cochrane Library from 1998-2012,5 conferences(American Society of Clinical Oncology,Endocrine Society,European Neuroendocrine Tumor Society,European Society for Medical Oncology,North American Neuroendocrine Tumor Society)from 2000-2013 using Me SH and keyterms including neuroendocrine tumors,carcinoid tumor,carcinoma,neuroendocrine,and octreotide.Bibliographies of accepted articles were also searched.Two reviewers reviewed titles,abstracts,and full-length articles.Studies that reported data on efficacy and safety of≥30 mg/mo octreotide-LAR for NETs in human subjects,published in any language were included in the review.RESULTS:The search identified 1086 publications,of which 238 underwent full-text review(20 were translated into English);17 were included in the review.Studies varied in designs,subjects,octreotide-LAR regimens,and definition of outcomes.Eleven studies reported use of higher doses to control symptoms and tumor progression,although symptom severity and formal quality-of-life analysis were not quantitatively measured.Ten studies reported efficacy,describing 260 subjects with doses ranging from 40 mg/mo or 30 mg/3 wk up to 120 mg/mo.Eight studies reported expert clinical opinion that supported dose escalation of octreotide-LAR up to 60 mg/mo for symptom control and suggested increased doses may be effective at preventing tumor progression.Eight studies reported safety;there was no evidence of increased toxicity associated with doses of octreotide-LAR>30 mg/mo.CONCLUSION:As reported in this review,octreotide-LAR at doses>30 mg/mo is being prescribed for symptom and tumor control in NET patients.Furthermore,expert clinical opinion provided support for escalation of somatostatin analogs for refractory hormonal symptoms. | Michael S Broder David Beenhouwer Jonathan R Strosberg Maureen P Neary Dasha Cherepanov | 2015 | World Journal of Gastroenterology2015，21，6： | 8 |
| 2 | Endoscopic evaluation in diagnosis and management of inflammatory bowel disease显示文摘Endoscopy is a keystone in the management of patients with inflammatory bowel disease(IBD).It is the fundamental diagnostic tool for IBD,and can help discern between ulcerative colitis and Crohn's disease.Endoscopic assessment provides an objective end point in clinical trials,and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy.Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy,and chromoendoscopy.Technological advances enable improved visualization and focused biopsy sampling.Endoscopic resection and close surveillance of dysplastic lesions where feasible is recommended instead of prophylactic colectomy. | Carthage P Moran Barra Neary Glen A Doherty | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 3 |
| 3 | Effects of wildfire on soils and watershed processes 显示文摘 | lee G G Neary D G Adams P W | 2004 | Journal of Forestry2004，102，6： | 1 |
| 4 | Common variation in the vitamin 0 receptor gene and risk of inflammatory bowel disease in an Irish case-control study显示文摘 | Hughes OJ McManus R Neary P O'morain C O'sullivan M | 2011 | Eu[J Gastroenterol Hepatol2011，23，9： | 1 |
| 5 | Transanal endoscopic microsurgery:a viable operative alternative in selected patients with rectal lesions显示文摘 | Neary P Makin GB White TJ | | 0，，09： | 1 |
| 6 | Comparison of POSSUM scoring and the Hardman Index in selection of patients for repair of ruptured abdominal aortic aneurysm显示文摘 | Neary WD Crow P Foy C | 2003 | Br J Surg2003，90，4： | 1 |
| 7 | Appetite Regulation:from the Gut to the Hypothalamus显示文摘 | NEARY N M GOLDSTONE A P BLOOM S R | 2004 | Clin Endocrinol2004，60，4： | 1 |
| 8 | Booming sector and de- industrialization in a small open economy 显示文摘 | Corden W M Neary J P | 1982 | Economic Journal1982，92，： | 1 |
| 9 | Absorptive capacity, R & D spillovers, and public policy 显示文摘 | LEAHY D NEARY J P | 2007 | International Journal of Industrial Organization2007，25，5： | 1 |
| 10 | Chemiluminescence, and bioluminescence in chemical analysis 显示文摘 | W R Seitz M P Neary | 1998 | Anal Chem1998，46，： | 1 |
| 11 | Booming sector and de industrializa- tion in a small open economy显示文摘 | W M Corden J P Neary | 1982 | Economic Journal1982，，92： | 1 |
| 12 | Public policy towards RD in oligopolistic industries显示文摘 | Leahy D Neary J P | 1997 | The American Economic Review1997，87，4： | 1 |
| 13 | Foreign competition and wage inequality显示文摘 | NEARY P J | 2002 | Review of International Economics2002，10，4： | 1 |
| 14 | Booming sector an de-industrialization in a small open economy显示文摘 | Corden W M Neary J P | 1982 | Economic Journal1982，92，368： | 1 |
| 15 | Diagnosis and treatment of enterovesicel fistula显示文摘 | Kavanash D Neary P Dodd JD et el | 2005 | Colorectel Dis2005，7，3： | 1 |
| 16 | Booming Sector and De - industrialization in a Small Open Economy 显示文摘 | Corden W M Neary J P | 1982 | Economic Journal1982，92，： | 1 |
| 17 | Effect of taper on endur- ance cycling capacity and single muscle fiber properties 显示文摘 | Neary JP Thomas P Martin H | 2003 | Med Sci Sports Exerc2003，35，11： | 1 |
| 18 | Immunonutrition:the role of taurine显示文摘 | Redmond H P Stapleton P P Neary P | 1998 | Nutrition1998，14，78： | 1 |
| 19 | A new approach to evaluating trade policy显示文摘 | Anderson J Neary P | 1996 | Review of Economic Studies1996，63，： | 1 |
| 20 | Electromyographic biofeedback can improve subjective and objective measures of fecal incontinence in the short term显示文摘 | Beddy P Neary P Eguare EI | 2004 | J Gastrointest Surg2004，8910，： | 1 |
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