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| 1 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 2 | Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial显示文摘 | JY Douillard D Cunningham AD Roth M Navarro RD James P Karasek P Jandik T Iveson J Carmichael M Alakl G Gruia L Awad P Rougier | 2000 | The Lancet2000，，9209： | 4 |
| 3 | In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium 显示文摘 | Navarro P Giner R M Recio M C | 2001 | Life Sci2001，68，10： | 2 |
| 4 | Polymorphisms in the endothelial protein C receptor gene and thrombophilia显示文摘 | Medina P Navarro S Estelles A | 2007 | Thromb Haemost2007，98，： | 1 |
| 5 | Oxidative stress induced by copper in sunflower plants显示文摘 | Garcia A Baquedano F J Navarro P | 1999 | Free Radical Research1999，31，10： | 1 |
| 6 | Why do corporations give to charity? Journal of Business 显示文摘 | Navarro P | | 610，1988，： | 1 |
| 7 | Thermo-rheological behaviour and storage stability of ground tire rubber-modified bitumens显示文摘 | NAVARRO F J PARTAL P MART?NEZ-BOZA F | 2004 | Fuel2004，83，14： | 1 |
| 8 | Damage control surgery in the era of damage control resuscitation 显示文摘 | Lamb CM MaeGoey P Navarro AP | 2014 | Br J Anaesth2014，113，2： | 1 |
| 9 | Rheological characteris- tics of ground the robber-modified bitumen显示文摘 | Navarro F J Partal P Martinez F et d | 2002 | Chemical Engi- neering Journal2002，89，13： | 1 |
| 10 | Porcine lgA allotypes are not equally transcribed or expressed in heterozygous swine 显示文摘 | Navarro P Christensen R K Weber P | 2000 | Molecular-Immunology2000，37，11： | 1 |
| 11 | CBN and vitrified bond:A new focus显示文摘 | Navarro N P | 1986 | Machine and tool blue book1986，81，10： | 1 |
| 12 | Acute respiratory distress syndrome in trauma patients : ICU mortality and prediction factors 显示文摘 | Navarrete - Navarro P Ruiz -Bailen M Rinera Fernandez R | 2000 | Intensive Care Med2000，26，： | 1 |
| 13 | Thermo-rheological behaviour and storage stability of ground tire rubber-modified bitumens显示文摘 | Navarro F J Partal P Martinez-Boza F | 2004 | Fuel2004，83，： | 1 |
| 14 | Envi ronmental heterogeneity, spatial segregation of prey, and the utilization o{ southwest Atlantic mud{iats by migratory shore birds显示文摘 | RIBE1RO P D IRIBARNE O O NAVARRO D | 2004 | Ibis2004，146，： | 1 |
| 15 | A maize defense-inducible gene is a major facilitator superfamily member related to bacterial multidrug resistance efflux antiporters显示文摘 | SIMMONS C R Fridlender M Navarro P A | | 0，，： | 1 |
| 16 | Novel recycled polyethylene/ground tire rubber/bitumen blends for use in roofing applications : Thermo-mechanical properties显示文摘 | Navarro F J Partal P Martinez-Boza F J | 2010 | Polymer Testing2010，29，5： | 1 |
| 17 | UVB effects on early developmental stages of commercially important macroalgae in southern Chile 显示文摘 | Navarro N P Mansilla A Palacios M | 2008 | J Appl Phyco12008，20，： | 1 |
| 18 | Adsorption of antimony and arsenic from a copper electrorefining solution onto activated carbon显示文摘 | Navarro P Alguacil F J | 2002 | Hydrometallurgy2002，66，123： | 1 |
| 19 | Influence of crumb rubber concentration on the rheological behavior of a crumb rubber modified bitumen显示文摘 | NAVARRO F J PARTAL P MART?NEZ-BOZA F | 2005 | Energy & Fuels2005，19，5： | 1 |
| 20 | Histamine induces tyrosine phospholylation of endothelial cell-to-cell adherens junctions 显示文摘 | Andriopoulou P Navarro P Zanetti A | 1999 | Arterioscler Thromb Vasc Biol1999，19，： | 1 |
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