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| 1 | 颈椎三维有限元模型的建立及意义显示文摘目的 :建立颈椎 (C4~C7)三维有限元模型 ,以期应用于临床实验研究。方法 :根据正常中年女性CT与CT重建片 ,采用CAD数据处理技术 ,输入相关的材料特性 ,构建C4~C7三维有限元模型。模型包括颈C4~C74个椎体、C4 / 5~C6 / 73个椎间盘以及后部结构与主要的 5条韧带。共 2 178个三维固体 2 0节点有限元结构。在1 8Nm作用力下 ,观察节段运动与力 位移反应。对比国内外的实验结果进行检验。结果 :生物力学实验结果与以往实验模型结果基本相符。结论 :所建立的颈椎三节段有限元模型可以模拟颈椎生物力学实验。 | 陈伯华J 孙鹏J Natarajan N An H Andersson GB | 2002 | 中国脊柱脊髓杂志2002，12，2： | 37 |
| 2 | Recent advances based on the synergetic effect of adsorption for removal of dyes from waste water using photocatalytic process显示文摘The problem of textile dye pollution has been addressed by various methods,mainly physical,chemical,biological,and acoustical.These methods mainly separate and/or remove the dye present in water.Recently,advanced oxidation processes(AOP)have been focused for removal of dye from waste water due to their advantages such as ecofriendly,economic and capable to degrade many dyes or organic pollutant present in water.Photocatalysis is one of the advance oxidation processes,mainly carried out under irradiation of light and suitable photocatalytic materials.The photocatalytic activity of the photocatalytic materials mainly depends on the band gap,surface area,and generation of electron–hole pair for degradation dyes present in water.It has been observed that the surface area plays a major role in photocatalytic degradation of dyes,by providing higher surface area,which leads to the higher adsorption of dye molecule on the surface of photocatalyst and enhances the photocatalytic activity.This present review discusses the synergic effect of adsorption of dyes on the photocatalytic efficiency of various nanostructured high surface area photocatalysts.In addition,it also provides the properties of the water polluting dyes,their mechanism and various photocatalytic materials;and their morphology used for the dye degradation under irradiation of light along with the future prospects of highly adsorptive photocatalytic material and their application in photocatalytic removal of dye from waste water. | Subramanian Natarajan Hari C.Bajaj Rajesh J.Tayade | 2018 | Journal of Environmental Sciences2018，30，3： | 22 |
| 3 | Design concepts of an aircraft wing: composite and morphing airfoil with auxetic structures显示文摘 | P R BUDARAPU Sudhir Sastry Y B R NATARAJAN | 2016 | Frontiers of Structural and Civil Engineering2016，10，4： | 10 |
| 4 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 5 | Isolation, identification, Pb(Ⅱ) biosorption isotherms and kinetics of a lead adsorbing Penicillium sp. MRF-1 from South Korean mine soil显示文摘A heavy metal contaminated soil sample collected from a mine in Chonnam Province of South Korea was found to be a source of heavy metal adsorbing biosorbents.Chemical analyses showed high contents of lead(Pb) at 357 mg/kg and cyanide(CN) at 14.6 mg/kg in the soil.The experimental results showed that Penicillium sp.MRF-1 was the best lead resistant fungus among the four individual metal tolerant fungal species isolated from the soil.Molecular characterization of Penicillium sp.MRF-1 was determined using ITS regions sequences.Effects of pH,temperature and contact time on adsorption of Pb(II) by Penicillium sp.MRF-1 were studied.Favorable conditions for maximum biosportion were found at pH 4 with 3 hr contact time.Biosorption of Pb(II) gradually increased with increasing temperature.Efficient performance of the biosorbent was described using Langmuir and Freundlich isotherms.Adsorption kinetics was studied using pseudo first-order and pseudo second-order models.Biosorbent Penicillium sp.MRF-1 showed the maximum desorption in alkali conditions.Consistent adsorption/desorption potential of the biosorbent in repetitive cycles validated the efficacy of it in large scale.SEM studies given notes on surface modification of fungal biomass under metal stress and FT-IR results showed the presence of amino groups in the surface structure of the biosorbent.In conclusion,the new biosorbent Penicillium sp.MRF-1 may potentially be used as an inexpensive,easily cultivatable material for the removal of lead from aqueous solution. | Natarajan Velmurugan Grim Hwang Muthuswamy Sathishkumar Tae Kie Choi Kui-Jae Lee Byung-Taek Oh Yang-Soo Lee | 2010 | Journal of Environmental Sciences2010，22，7： | 7 |
| 6 | Exposure to polycyclic aromatic hydrocarbons with special focus on cancer显示文摘Polycyclie aromatic hydrocarbons(PAHs) are a group of compounds consisting of two or more fused aromatic rings.Most of them are formed during incomplete combustion of organic materials such as wood and fossil fuels,petroleum products,and coal.The composition of PAH mixtures varies with the source and is also affected by selective weathering effects in the environment.PAHs are ubiquitous pollutants frequently found in a variety of environments such as fresh water and marine sediments,the atmosphere,and ice.Due to their widespread distribution,the environmental pollution due to PAHs has aroused global concern.Many PAHs and their epoxides are highly toxic,mutagenic and/or carcinogenic to microorganisms as well as to higher forms of life including humans.The main aim of this review is to provide contemporary information on PAH sources,route of exposure,worldwide emission rate,and adverse effects on humans,especially with reference to cancer. | Thamaraiselvan Rengarajan Peramaiyan Rajendran Natarajan Nandakumar Boopathy Lokeshkumar Palaniswami Rajendran Ikuo Nishigaki | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，3： | 6 |
| 7 | 妊娠期高血压疾病对远期心血管病的影响显示文摘对妇女妊娠期高血压疾病(hypertensive disorder of pregnancy,HDP)史的研究,可能有助于改善动脉粥样硬化性心血管病的风险评估。但是,有HDP既往史的中年无症状妇女在未来患心血管病的风险仍未知。该研究旨在探讨有或无HDP既往史的中年女性心血管病的远期发病率。纳入标准:在前瞻性、观察性英国生物资料库中,纳入40~69岁并至少有一活产的英国妇女,对其中一亚组妇女进行了无创性动脉硬度测量。 | 周卫(译) 叶鹏(摘、审校) Honigberg MC Zekavat SM Aragam K Klarin D Bhatt DL Scott NS Peloso GM Natarajan P | 2020 | 中华高血压杂志2020，28，2： | 6 |
| 8 | Anti-inflammatory activity of Alpinia officinarum hance on rat colon inflammation and tissue damage in DSS induced acute and chronic colitis models显示文摘The purpose of this study was to investigate the possible prophylactic effects of Alpinia officinarum hance on experimentally induced acute and chronic colitis models,in-vivo and in-vitro.Acute and chronic colitis were induced in Male Wistar rats by administration of Dextran Sulfate Sodium(DSS)in drinking water.DSS induction exhibited colon shrinkage,increased the Disease Activity Index(DAI)score,increased the levels of inflammatory markers and caused severe anemia.DSS induced animals,co-treated with the hexane extract of Alpinia officinarum(HEAO)(200 mg/kg body wt),effectively suppressed colonic injury that was evidenced by the reduced DAI score,colon weight/length ratio,histological damage,proinflammatory markers and MPO activity.Further,it restored the colonic antioxidants near to normal levels by regulating the oxidative stress via attenuation of lipid peroxidation.Our results revealed that the degree of colitis caused by the administration of DSS was significantly attenuated by HEAO.In addition,the in-vitro study showed that HEAO treatment inhibited the proliferation of HT-29 cells and down regulated the mRNA expression of NF-B and COX-2.Taken together,these results suggest that HEAO is a promising anti-oxidant and anti-inflammatory agent that support its possible therapeutic role in the treatment of colitis. | Vijayabharathi Rajendiran Vidhya Natarajan Sivasithamparam Niranjali Devaraj | 2018 | Food Science and Human Wellness2018，7，4： | 5 |
| 9 | In vitro biofilm formation by uropathogenic Escherichia coli and their antimicrobial susceptibility pattern显示文摘Objective:To detect in vitro biofilm formation of uropathogenic Escherichia coli(E.coli)(UPEC) strains isolated from urine specimens and also to determine their antimicrobial susceptibility pattern using 13 commonly used antibiotics.Methods:The present study comprised of 166 urine specimens collected from tertiary care hospitals in and around Coimbatore.South India. All the specimens were subjected to gram staining,bacterial culture and the E.coli strains were screened for biofilm formation using Tube Method(TM),Congo Red Agar(CRA) and Tissue Culture Plate method(TCP) respectively.Subsequently,the antimicrobial susceptibility test was performed by Kirby Bauer-disk diffusion method for the biofilm and non-biofilm producing E. coli strains.Results:Of the 100(60.2%) E.coli strains,72 strains displayed a biofilm positive phenotype under the optimized conditions in the Tube Method and the strains were classified as highly positive(17,23.6%),moderate positive(19.26.3%) and weakly positive(36.50.0%). similarly under the optimized conditions on Congo Red agar medium,biofilm positive phenotype strains were classified as highly positive(23,23%).moderate positive(37.37%) and weakly positive(40,40%).While in TCP method,the biofilm positive phenotype strains were also classified as highly positive(6.6%),moderate positive(80.80%) and weakly positive(14,14%),it didn’t not correlate well with the tube method for detecting biofilm formation in E.coli.The rates of antibiotic resistance of biofilm producing E.coli were found to be 100%for chloramphenicol and amoxyclav(amoxicillin and clavulanic acid),86%for gentamicin and cefotaxime.84%for ceftazidime,83%for cotrimoxazole and piperacillin/tazobactam,75%for tetracycline and 70% for amikacin,Conclusions:This study reveals the prevalence and antimicrobial susceptibility pattern of biofilm and non-biofilm producing uropathogenic E.coli strains. | Poovendran Ponnusamy Vidhya Natarajan Murugan Sevanan | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，3： | 5 |
| 10 | 纳米钯催化苄基氯代物与烯丙基硼酸频哪醇酯的羧化Suzuki偶联反应(英文)显示文摘CO_2是廉价的Cl源,同时具有无毒、储量丰富的优点,符合绿色化学发展要求.利用CO_2构筑新的C-C键是化学固定CO_2的重要方法.β,γ-不饱和酯类结构单元是许多生物活性分子的重要组成部分,经由双π-烯丙基钯中间体与CO_2反应,合成新的β,γ-不饱和酯类化合物,具有重要意义.CO_2与有机硼化合物的羧化反应己有报道,有机硼化合物具有低毒、对水不敏感等优点.但是己报道的羧化Suzuki偶联反应存在诸多缺点:(1)需要使用含膦或者氮杂环卡宾配体的催化剂,而这些催化剂的制备过程使前期实验步骤变得冗长,同时反应液的酸化后处理过程也会造成环境污染;(2)有机硼试剂的官能团兼容范围窄,限制了底物范围的拓展.本课题组以原位生成的纳米钯粒子为催化剂,在CO_2存在的温和条件下,高效实现了苄氯与烯丙基硼酸频哪醇酯的羧化Suzuki偶联反应.反应过程中无其它配体加入,反应结束后不需要酸化或酯化的后处理过程.该反应将具有广泛的官能团兼容性.本文以TBAB稳定的纳米钯粒子为催化剂,在温和条件下,实现了氯甲基芳香化合物、烯丙基硼酸频哪醇酯和CO_2的三组分羧化Suzuki偶联反应.最佳反应条件为:Pd(acac)_2(5mol%)、TBAB(0.7mmol,1.4 equiv.)、KF(1mmol,2.0 equiv.)、苄基卤代物(0.5 mmol)、烯丙基硼酸频哪醇酯(0.6 mmol,1.2 equiv.)、CO_2(2.0 MPa)、溶剂THF(5 mL),50℃反应24h.在最佳反应条件下,苯环、萘环以及杂芳环的氯甲基化合物均可发生该羧化反应.苯环上取代基的位置对产物的收率有影响.当使用1-溴甲基萘作为底物时反应也能够发生,收率与1-氯甲基萘作为底物时的收率相当.与已报道有机硼试剂的羧化反应相比,该反应体系无需加入配体,原位生成了纳米钯粒子,避免了催化剂或者配体的复杂制备过程.该反应中,氟离子的存在是必要的,对烯丙基硼酸频哪醇酯具有活化作用. | 孙健 王加升 冯秀娟 Yoshinori Yamamoto Abdulrahman I.Almansour Natarajan Arumugam Raju Suresh Kumar 包明 | 2018 | Chinese Journal of Catalysis2018，39，7： | 4 |
| 11 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 12 | 联合国教科文组织“人与生物圈”计划40周年 全球回顾与展望显示文摘2011年是联合国教科文组织提出并实施“人与生物圈”计划40周年,中国人与生物圈国家委员会将举行各种庆祝活动,出版《人与生物圈》杂志系列特别纪念专辑是其中之一。为了让读者更好地更深入地了解这一项伟大的全球性政府间科学计划,本刊记者专门采访了联合国教科文组织地球科学与生态科学处处长兼人与生物圈计划国际秘书处秘书长NatarajanIshwaran先生(简称Ishwaran)。 | Natarajan Ishwaran 陈向军 先义杰 王瑾 | 2011 | 人与生物圈2011，，3： | 3 |
| 13 | Ciona intestinalis as an emerging model organism: its regeneration under controlled conditions and methodology for egg dechorionation显示文摘 | LIU Li-ptng XIANG Jian-hai DONG Bo NATARAJAN Pavanasam YU Kui-jie CAI Nan-er | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，6： | 3 |
| 14 | First Complete Genome Sequence of a Probiotic Enterococcus faecium Strain T-110 and Its Comparative Genome Analysis with Pathogenic and Non-pathogenic Enterococcus faecium Genomes显示文摘Enterococci bacteria are important in environmental,food and clinical microbiology.Enterococcus faecium is a nosocomial pathogen that causes bacteremia,endocarditis and other infections.It is among the most prevalent organisms encountered in hospital-associated infections accounting for approximately 12%of nosocomial infections in the USA(Linden and Miller,1999).However,certain strains of E.faecium are not only non-pathogenic but also have | Purushothaman Natarajan Madasamy Parani | 2015 | Journal of Genetics and Genomics2015，42，1： | 3 |
| 15 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 16 | Monitoring vegetation dynamics in East Rennell Island World Heritage Site using multi-sensor and multi-temporal remote sensing data显示文摘East Rennell of Solomon Island is the first natural site under customary law to be inscribed on UNESCO’s World Heritage List.Potential threats due to logging,mining and agriculture led to the site being declared a World Heritage in Danger in 2013.For East Rennell World Heritage Site(ERWHS)to‘shed’its‘Danger’status the management must monitor forest cover both within and outside of ERWHS.We used satellite data from multiple sources to track forest cover changes for the entire East Rennell island since 1998.95%of the island is still covered by undisturbed forests;annual average normalized difference vegetation index(NDVI)for the whole island was above 0.91 in 2015.However,vegetation cover in the island has been slowly decreasing,at a rate of–0.0011 NDVI per year between 2000 and 2015.This decrease less pronounced inside ERWHS compared to areas outside.While potential threats due to forest clearing outside ERWHS remain the forest cover change from 2000 to 2015 has been below 15%.We suggest ways in which the Government of Solomon Islands could use our data as well as unmanned air vehicles and field surveys to monitor forest cover change and ensure the future conservation of ERWHS. | Mengmeng Wang Guojin He Natarajan Ishwaran Tianhua Hong Andy Bell Zhaoming Zhang Guizhou Wang Meng Wang | 2020 | International Journal of Digital Earth2020，13，3： | 3 |
| 17 | MicroRNAs in neuroblastoma tumorigenesis,therapy resistance,and disease evolution显示文摘Neuroblastoma(NB)deriving from neural crest cells is the most common extra-cranial solid cancer at infancy.NB originates within the peripheral sympathetic ganglia in adrenal medulla and along the midline of the body.Clinically,NB exhibits significant heterogeneity stretching from spontaneous regression to rapid progression to therapy resistance.MicroRNAs(miRNAs,miRs)are small(19-22 nt in length)non-coding RNAs that regulate human gene expression at the post-transcriptional level and are known to regulate cellular signaling,growth,differentiation,death,stemness,and maintenance.Consequently,the function of miRs in tumorigenesis,progression and resistance is of utmost importance for the understanding of dysfunctional cellular pathways that lead to disease evolution,therapy resistance,and poor clinical outcomes.Over the last two decades,much attention has been devoted to understanding the functional roles of miRs in NB biology.This review focuses on highlighting the important implications of miRs within the context of NB disease progression,particularly miRs’influences on NB disease evolution and therapy resistance.In this review,we discuss the functions of both the“oncomiRs”and“tumor suppressor miRs”in NB progression/therapy resistance.These are the critical components to be considered during the development of novel miR-based therapeutic strategies to counter therapy resistance. | Natarajan Aravindan Karthikeyan Subramanian Dinesh Babu Somasundaram Terence S.Herman Sheeja Aravindan | 2019 | Cancer Drug Resistance2019，2，4： | 3 |
| 18 | Chemical composition and antioxidant capacity of the aqueous extract of Phellodendron amurense显示文摘The aqueous extract of Phellodendron amurense Rupr.(Amur Cork Tree) provides a rich source of antioxidants and chemical compounds, and can be used for food and wood preservative materials.In this study, we characterized the chemical composition of this extract by GC and GC/MS.The antioxidant capacity was evaluated using a variety of antioxidant assays(superoxide radical,hydroxyl radical, nitric oxide radical, and DPPH radical scavenging activity).Additionally, total polyphenolic content was determined.Phenolic acids and acetone derivatives were major compounds of the extract capable of scavenging the DPPH free radical and reducing ferric ions.DPPH and ferric ion reduction results were strongly correlated with total phenolic content of the extract which also exhibited strong nitric oxide, hydroxyl radical scavenging and superoxide anion radical scavenging activities. | Natarajan Velmurugan Duraisamy Kalpana Jae Young Cho Yang Soo Lee | 2018 | Journal of Forestry Research2018，29，4： | 3 |
| 19 | Silver nanoparticles tolerant bacteria from sewage environment显示文摘Silver nanoparticle (SNP) is a threat to soil,water and human health.Protection of environment from silver nanoparticles is a major concern.A sewage isolate,Bacillus pumilus treated with SNPs showed similar growth kinetics to that without nanoparticles.A reduction in the amount of exopolysaccharides was observed after SNPs-B.pumilus culture supernatant interaction.The Fourier transform infrared spectroscopy (FT-IR) peaks for the exopolysaccharides extracted from the bacterial culture supernatant and the interacted SNPs were almost similar.The exopolysaccharide capping of the SNPs was confirmed by UV-Visible,FT-IR and X-ray diffraction analysis.The study of bacterial exopolysaccharides capped SNPs with E.coli,S.aureus and M.luteus showed less toxicity compared to uncoated SNPs.Our studies suggested that the capping of nanoparticles by bacterially produced exopolysaccharides serve as the probable mechanism of tolerance. | Sudheer Khan Amitava Mukherjee Natarajan Chandrasekaran | 2011 | Journal of Environmental Sciences2011，23，2： | 3 |
| 20 | An innovative approach to minimize excess sludge production in sewage treatment using integrated bioreactors显示文摘The present investigation deals with an application of integrated sequential oxic and anoxic bioreactor(SOABR) and fluidized immobilized cell carbon oxidation(FICCO) reactor for the treatment of domestic wastewater with minimum sludge generation. The performance of integrated SOABR-FICCO system was evaluated on treating the domestic wastewater at hydraulic retention time(HRT) of 3 hr and 6 hr for 120 days at organic loading rate(OLR)of 191 ± 31 mg/(L·hr). The influent wastewater was characterized by chemical oxygen demand(COD) 573 ± 93 mg/L; biochemical oxygen demand(BOD5) 197 ± 35 mg/L and total suspended solids(TSS) 450 ± 136 mg/L. The integrated SOABR-FICCO reactors have established a significant removal of COD by 94% ± 1%, BOD5 by 95% ± 0.6% and TSS by 95% ± 4% with treated domestic wastewater characteristics COD 33 ± 5 mg/L; BOD59 ± 0.8 mg/L and TSS 17 ± 9 mg/L under continuous mode of operation for 120 days. The mass of dry sludge generated from SOABR-FICCO system was 22.9 g/m^3. The sludge volume index of sludge formed in the SOABR reactor was 32 mL/g and in FICCO reactor it was 46 mL/g. The sludge formed in SOABR and FICCO reactor was characterized by TGA, DSC and SEM analysis. Overall, the results demonstrated that the integrated SOABR-FICCO reactors substantially removed the pollution parameters from domestic wastewater with minimum sludge production. | Mahesh Mannacharaju Prabhakaran Natarajan Arivizhivendhan Kannan Villalan Madasamy Jothieswari Swarnalatha Somasundaram Sekaran Ganesan | 2018 | Journal of Environmental Sciences2018，30，5： | 3 |
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