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| 1 | GLOBAL STABILITY OF EXTENDED MULTI-GROUP SIR EPIDEMIC MODELS WITH PATCHES THROUGH MIGRATION AND CROSS PATCH INFECTION显示文摘In this article, we establish the global stability of an endemic equilibrium of multi-group SIR epidemic models, which have not only an exchange of individuals between patches through migration but also cross patch infection between different groups. As a result, we partially generalize the recent result in the article [16]. | Yoshiaki MUROYA Yoichi ENATSU Toshikazu KUNIYA | 2013 | Acta Mathematica Scientia2013，33，2： | 7 |
| 2 | ON GLOBAL STABILITY OF A NONRESIDENT COMPUTER VIRUS MODEL显示文摘In this paper, we establish new sufficient conditions for the infected equilibrium of a nonresident computer virus model to be globally asymptotically stable. Our results extend two kind of known results in recent literature. | Yoshiaki MUROYA Huaixing LI Toshikazu KUNIYA | 2014 | Acta Mathematica Scientia2014，34，5： | 6 |
| 3 | GLOBAL STABILITY OF SIRS EPIDEMIC MODELS WITH A CLASS OF NONLINEAR INCIDENCE RATES AND DISTRIBUTED DELAYS显示文摘In this article,we establish the global asymptotic stability of a disease-free equilibrium and an endemic equilibrium of an SIRS epidemic model with a class of nonlinear incidence rates and distributed delays.By using strict monotonicity of the incidence function and constructing a Lyapunov functional,we obtain sufficient conditions under which the endemic equilibrium is globally asymptotically stable.When the nonlinear incidence rate is a saturated incidence rate,our result provides a new global stability condition for a small rate of immunity loss. | Yoichi Enatsu Yukihiko Nakata Yoshiaki Muroya | 2012 | Acta Mathematica Scientia2012，32，3： | 5 |
| 4 | Lactogenic hormones alter cellular and extracellular microRNA expression in bovine mammary epithelial cell culture显示文摘Background: Bovine milk contains not only a variety of nutritional ingredients but also micro RNAs(mi RNAs) that are thought to be secreted by the bovine mammary epithelial cells(BMECs). The objective of this study was to elucidate the production of milk-related mi RNAs in BMECs under the influence of lactogenic hormones.Results: According to a microarray result of milk exosomal mi RNAs prior to cellular analyses, a total of 257 mi RNAs were detected in a Holstein cow milk. Of these, 18 major mi RNAs of interest in the milk were selected for an expression analysis in BMEC culture that was treated with or without dexamethasone, insulin, and prolactin(DIP) to induce a lactogenic differentiation. Quantitative polymerase chain reaction(q PCR) results showed that the expressions of mi R-21–5p(P = 0.005), mi R-26a(P = 0.016), and mi R-320a(P = 0.011) were lower in the DIP-treated cells than in the untreated cells. In contrast, the expression of mi R-339a(P = 0.017) in the cell culture medium were lower in the DIP-treated culture than in the untreated culture. Intriguingly, the mi R-148 a expression in cell culture medium was elevated by DIP treatment of BMEC culture(P = 0.018). The medium-to-cell expression ratios of mi R-103(P = 0.025), mi R-148a(P < 0.001), and mi R-223(P = 0.013) were elevated in the DIP-treated BMECs, suggesting that the lactogenic differentiation-induced secretion of these three mi RNAs in BMECs. A bioinformatic analysis showed that the mi RNAs down-regulated in the BMECs were associated with the suppression of genes related to transcriptional regulation, protein phosphorylation, and tube development.Conclusion: The results suggest that the mi RNAs changed by lactogenic hormones are associated with milk protein synthesis, and mammary gland development and maturation. The elevated mi R-148 a level in DIP-treated BMECs may be associated with its increase in milk during the lactation period of cows. | Susumu Muroya Tatsuro Hagi Ataru Kimura Hisashi Aso Masatoshi Matsuzaki Masaru Nomura | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 5 |
| 5 | Protective effects of silybin and analogues against X-ray radiation-induced damage显示文摘Silybin (SLB ) 和类似的类似物,也就是 hesperetin (HESP ) , naringenin (NAN ) 和 naringin (NAR ) ,被相信是为某些癌症作为 chemopreventive 代理人被报导了的自然 flavonoids 的活跃成分。而且, SLB 和类似物被决定了快由脉搏 radiolysis 技术从氧化损坏修理 DNA 底。现在的学习被设计评估 SLB 的保护的效果,软 X-ray-induced 上的类似物在 vitro 损坏 DNA 到 plasmid。DNA 损坏被 agarose 胶化电气泳动决定。SLB 和类似物被发现在 micromolar 集中保护 DNA 免受放射损坏的伤害。在测试的混合物之中, HESP 和 SLB 在阻止 DNA 单个海滨的裂缝(SSB ) 的 X-ray-induced 形成是最有效的。有另外的实验的这些结果的比较证明 SLB 和类似物的能力与混合物的能力相关在 vitro 禁止 DNA 损坏清除自由激进分子。我们的工作表明自然 flavonoids, SLB 和类似物可以对放射损坏被用作有势力辐射防护药物。 | Haiying Fu Mingzhang Lin Yosuke Katsumura Akinari Yokoya Kuniki Hata Yusa Muroya Kentaro Fujii Naoya Shikazono | 2010 | Acta Biochimica et Biophysica Sinica2010，42，7： | 4 |
| 6 | Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer显示文摘AIM: To investigate the clinical significance of BMP and activin membrane-bound inhibitor (BAMBI) which is a pseudoreceptor of transforming growth factor-beta (TGF-β) type Ⅰreceptors and acts as a negative regulator of TGF-β signaling and expression aberrantly elevated in colorectal cancers (CRCs). We studied BAMBI expression in CRCs. METHODS: We studied BAMBI expression in 183 surgically resected CRCs by immunochemical and immunoblotting analyses using a generated monoclonal anti-BAMBI antibody. Commercially available anti-β-catenin and anti-p53 antibodies were also applied for immunochemical analyses as a comparison control.RESULTS: Immunohistochemical analysis revealed that BAMBI expression was observed in 148 (80.8%), and strong BAMBI expression was observed in 46% of the CRCs. Strong BAMBI expression was positively correlated with histological type, depth of invasion, lymph node metastases, and tumor node metastasis (TNM) stage (P < 0.05). Clear associations were found between BAMBI and β-catenin (P = 0.035) and p53 (P = 0.049) expression. In curatively resected CRC, 5-year recurrence-free survival was 51.9% (P = 0.037) for strong BAMBI expression compared to 79.8% for weak BAMBI expression. In the Cox’s multivariate analysis, lymph node metastases (RR 6.685; P < 0.001) and depth of invasion (RR 14.0; P = 0.013) were signifi cant indicators for recurrence, and strong BAMBI expression (RR 2.26; P = 0.057) tended to be signifi cant. CONCLUSION: BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC. | Nozomi Togo Susumu Ohwada Shinji Sakurai Hiroyuki Toya Ichiro Sakamoto Tatsuya Yamada Tetsuhiro Nakano Ken Muroya Izumi Takeyoshi Takashi Nakajima Takashi Sekiya Yusuke Yamazumi Tsutomu Nakamura Tetsu Akiyama | 2008 | World Journal of Gastroenterology2008，14，31： | 3 |
| 7 | Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus显示文摘 | Muroya S Uramura K Sakurai T | | 0，，： | 2 |
| 8 | Characterization of ribonuclease HⅡ from Escherichia coli overproduced in a soluble form显示文摘 | Ohtani N Haruki M Muroya A | 2000 | J Biochem2000，127，5： | 1 |
| 9 | Photodynamic therapy (PDT) for early cervical cancer显示文摘 | Muroya T Suehiro Y Umayahara K | 1996 | Gan To Kagaku Ryoho1996，23，1： | 1 |
| 10 | Skeletal features and growth patterns in 14 patients with haploinsufficiency of SHOX: Implications for the development of Turner syndrome显示文摘 | Kosho T Muroya K Nagai | 1999 | J Clin Endocrlnol Metab1999，84，： | 1 |
| 11 | Lyapunov functional techniques for the global stability analysis of a delayed SIRS epi- demic model显示文摘 | ENATSU Y NAKATA N MUROYA Y | 2012 | Nonlinear Analysis: Real World Applications2012，13，5： | 1 |
| 12 | High dose immune globulin therapy ameliorates peripartum cardiomyopathy with elevated serum antibody titer to influenza virus显示文摘 | MUROYA T IKEDA S YAMASA T | 2010 | Med Sci Monit2010，16，： | 1 |
| 13 | Lyapunov functional techniques for the global stability analy?sis of a delayed SIRS epidemic model显示文摘 | Enatsu Y Nakata Y Muroya Y | 2012 | Nonlinear Analysis: Real World Applications2012，13，5： | 1 |
| 14 | Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y显示文摘 | Muroya S Yada T Shioda S | 1999 | Neurosci Lette1999，264，13： | 1 |
| 15 | Molecular characteristics and site specific distribution of the pigment of the silky fowl 显示文摘 | Muroya S Tanabe R Nakajima I | 2000 | J vet Med Sci2000，62，4： | 1 |
| 16 | Profiling of differentially expressed microRNA and the bioinfor- matic target gene analyses in bovine fast- and slow- type muscles by massively parallel sequencing显示文摘 | Muroya S Taniguchi M Shibata M | 2013 | J Anim Sci2013，91，1： | 1 |
| 17 | The effect of leptin on feeding-regulating neurons in the rat hypothalamus显示文摘 | Funahashi H Yada T Muroya S | 1999 | Neurosci Lett1999，264，13： | 1 |
| 18 | Toxity of extracellular products and intracellular components of Edwardsiella tarda in the Japanes eel and flounder显示文摘 | Suprapto H Nakai T Muroya K | 1995 | J Aquatic Animal Health1995，7，： | 1 |
| 19 | Permanence and global stability in a lotka volterra predator-prey system with delays 显示文摘 | Muroya Y | 2003 | Applied Mathematics Letters2003，16，： | 1 |
| 20 | Related expression of MyoD and Myf5 with myosin heavy chain isoform types in bovine adult skeletal muscles 显示文摘 | Muroya S Nakajima I Chikuni K | 2002 | Zool Sci2002，19，7： | 1 |
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