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| 1 | What operation for recurrent rectal prolapse after previous Delorme's procedure? A practical reality显示文摘AIM: To report our experience with perineal repair(Delorme's procedure) of rectal prolapse with particular focus on treatment of the recurrence.METHODS: Clinical records of 40 patients who underwent Delorme's procedure between 2003 and 2014 were reviewed to obtain the following data: Gender; duration of symptoms, length of prolapse, operation time, ASA grade, length of post-operative stay, procedure-related complications, development and treatment of recurrent prolapse. Analysis of post-operative complications, rate and time of recurrence and factors influencing the choice of the procedure for recurrent disease was conducted. Continuous variables were expressed as the median with interquartile range(IQR). Statistical analysis was carried out using the Fisher exact test.RESULTS: Median age at the time of surgery was 76 years(IQR: 71-81.5) and there were 38 females and 2 males. The median duration of symptoms was 6 mo(IQR: 3.5-12) and majority of patients presented electively whereas four patients presented in the emergency department with irreducible rectal prolapse. The median length of prolapse was 5 cm(IQR: 5-7), median operative time was 100 min(IQR: 85-120) and median post-operative stay was 4 d(IQR: 3-6). Approximately16% of the patients suffered minor complications such as- urinary retention, delayed defaecation and infected haematoma. One patient died constituting postoperative mortality of 2.5%. Median follow-up was 6.5 mo(IQR: 2.15-16). Overall recurrence rate was 28%(n = 12). Recurrence rate for patients undergoing an urgent Delorme's procedure who presented as an emergency was higher(75.0%) compared to those treated electively(20.5%), P value 0.034. Median time interval from surgery to the development of recurrence was 16 mo(IQR: 5-30). There were three patients who developed an early recurrence, within two weeks of the initial procedure. The management of the recurrent prolapse was as follows: No further intervention(n = 1), repeat Delorme's procedure(n = 3), Altemeier's procedure(n = 5) and rectopexy with faecal diversion(n = 3). One patient was lost during follow up.CONCLUSION: Delorme's procedure is a suitable treatment for rectal prolapse due to low morbidity and mortality and acceptable rate of recurrence. The management of the recurrent rectal prolapse is often restricted to the pelvic approach by the same patientrelated factors that influenced the choice of the initial operation, i.e., Delorme's procedure. Early recurrence developing within days or weeks often represents a technical failure and may require abdominal rectopexy with faecal diversion. | Muhammad A Javed Faryal G Afridi Dmitri Y Artioukh | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 4 |
| 2 | Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model 显示文摘 | KING G D MUHAMMAD A K CURTIN J F | 2008 | Neuro Oncol2008，10，1： | 1 |
| 3 | Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity显示文摘 | Muhammad A Cowley Andrew R Moloney Mark G | 2010 | Tetrahedron: Asymmetry2010，21，1314： | 1 |
| 4 | Information Regarding Agronomic Practices and Plant Protection Measures Obtained by the Farmers through Electronic Media显示文摘 | Khan G A Muhammad S Ch K M | 2013 | Journal of Animal and Plant Sciences2013，23，2： | 1 |
| 5 | Strict group testing and the set basis problem显示文摘 | Damaschke P Muhammad A S Wiener G | 2014 | Journal of Combinator[M Theory Series A2014，126，： | 1 |
| 6 | Polarised finite difference analysis of D-fiber and applications for chemical sensing显示文摘 | MUHAMMAD F A STEWART G | 1992 | Int J Optoelectron1992，7，6： | 1 |
| 7 | Effect of nickel loading on hydrogenproduction and chemical oxygen demand(COD)destruction from glucose oxidation and gasification insupercritical water显示文摘 | Youssef Emhemmed A Chowdhury Muhammad B I Nakhla G | 2010 | International Journal of HydrogenEnergy2010，35，10： | 1 |
| 8 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 9 | Porous TiNi alloy by metal injection moulding sintering of ele- mental powders: effect of sintering temperature显示文摘 | Muhammad H I Russe 11 G Hywel A | 2012 | materials letters2012，，70： | 1 |
| 10 | Stem cells in normal breast development and breast cancer显示文摘 | Dontu G Muhammad A H Abdallah W M | 2003 | Cell Proliferation2003，36，1： | 1 |
| 11 | Integrated application of up-flow anaerobic sludge blanket reactor for the treatment of wastewaters显示文摘 | Muhammad A L Rumana G Zularisam A W | 2011 | Water Research2011，45，16： | 1 |
| 12 | Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung显示文摘 | Ziady A G Gedeon C R Muhammad O | 2003 | Mol Therapy2003，8，6： | 1 |
| 13 | The relative contributions of insulin resistance and beta cell failure to the transition from normal to impaired glucose tolerance varies in different ethnic groups 显示文摘 | Muhammad A Abdul G Masafumi M | 2007 | Diabetes & metabolic syndrome2007，1，： | 1 |
| 14 | Host plants of cotton mealybug(Phenacoccus solenopsis): A new menace to cotton agroecosystem of Punjab, Pakistan 显示文摘 | Muhammad I A Muhammad R Abdul G | 2009 | International Journal of Agriculture and Biology2009，11，2： | 1 |
| 15 | Strict group testing and the set basis problem显示文摘 | Damaschke P Muhammad A S Wiener G | 2014 | Journal of Combinatorial Theory Series A2014，126，： | 1 |
| 16 | Strict group testing and the set basis problem显示文摘 | Damaschke P Muhammad A S Wiener G | 2014 | Journal of Combinatorial Theory Series A2014，126，： | 1 |
| 17 | Formation of dynamic membranes with cross flow microfiltration 显示文摘 | Muhammad H A1-Malack G K A | 1996 | Journal of Membrane Science1996，112，： | 1 |
| 18 | Water purification by electrical discharges显示文摘 | Muhammad A M Abdul G Salman A M | 2001 | Plasma Source Sci Technol2001，10，： | 1 |
| 19 | A simple and efficient method for DNA extraction from grapevine cultivars and Vitis species显示文摘 | MUHAMMAD A L YE G N WEEDEN N F REISCH B I | 1994 | Plant Mol Biol Rep1994，12，1： | 1 |
| 20 | High capacity adenovirus vector-mediated anti-glioma genetherapy in the presence of systemic antiadenovirus immunity显示文摘 | King G D Muhammad A K Xiong W | 2008 | J Virol2008，82，9： | 1 |
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