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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Research on fatigue cracking growth parameters in asphaltic mixtures using computed tomography显示文摘 | D Braz R T Lopes L M G Motta | 2004 | Nclear Instruments and Methods in Physics Research B 2132004，，： | 1 |
| 3 | Sirt1 regulates insulin secretion by repressing UCP 2 in pancreatic beta cells显示文摘 | Bordone L Motta MC Picard F | 2006 | PLoS Biol2006，4，2： | 1 |
| 4 | Q-switched alexandrite laser-assisted treatment of melasma: 2-year follow-up monitoring 显示文摘 | Rusciani A Motta A Rusciani L | 2005 | J Drugs Dermatol2005，4，6： | 1 |
| 5 | Laboratory evaluation of recycled construction and demolition waste for pavements显示文摘 | Leite F D Motta R S Kamilla L V | 2011 | Construction and Building Materials2011，25，6： | 1 |
| 6 | Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 显示文摘 | Cosconati S Marinelli L La Motta C | 2009 | J Med Chem2009，52，18： | 1 |
| 7 | Theoretical and practical aspects of robot calibration with experimental verification 显示文摘 | Ginani L S Motta J M S T | 2011 | Journal of the Brazilian Society of Mechanical Sciences and Engineering2011，33，1： | 1 |
| 8 | Sirtl regulates insulin secretion by repressing UCP2 in pancreatic β cells显示文摘 | BORDONE L MOTTA M C PICARD F | 2006 | Plos Biol2006，4，： | 1 |
| 9 | Sirtl regulates insulin secretion by repressing UCP2 in pancreatic beta cells 显示文摘 | Bordone L Motta MC Picard F | 2006 | PLoS Biol2006，4，2： | 1 |
| 10 | 显示文摘 | Motta A Fambri L Migliaresi C | 2002 | Macromol Chem Phys2002，203，： | 1 |
| 11 | Immune system develop- ment in infants born to mothers with autoimmune disease, ex- posed in utero to immunosuppressive agents 显示文摘 | Motta M Ciardelli L Marconi M | 2007 | Am J Perinatol2007，24，8： | 1 |
| 12 | Serum hepcidin and macrophage iron correlate with NCP-1 release and vascular damage in patients with metabolic syndrome alterations显示文摘 | Valenti L Dongiovanni P Motta BM | | 0，，： | 1 |
| 13 | Alterations of the lymphocytic setup in elderly patients with cancer显示文摘 | Motta M Fedito L Malaguarnera L | 2003 | Arch Gerontol Geriatr2003，36，1： | 1 |
| 14 | Cellular automata with fuzzy parameters in microscopic study of positive HIV individuals显示文摘 | Motta Jafelice R Bechara B F Z Barros L C | 2009 | Mathematical and Computer Modelling2009，50，2： | 1 |
| 15 | Evaluation of tibial plateau fractures:efficacy of MR imaging compared with CT显示文摘 | Kode L Lieberman JM Motta AO | 1994 | AJR Am J Roentgenol1994，163，1： | 1 |
| 16 | Efficiency of energy recovery from waste incineration,in the light of the new Waste Framework Directive显示文摘 | GROSSO M MOTTA A RIGAMONTI L | 2010 | Waste Management2010，，30： | 1 |
| 17 | Sirt1regulates insulin secretion by repressing UCP2in pancreatic beta cells显示文摘 | Bordone L Motta MC Picard F | 2006 | PLoS Biol2006，4，2： | 1 |
| 18 | Increased expression of CD152(CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia显示文摘 | Motta M Rassenti L Shelvin BJ | 2005 | Leukemia2005，19，10： | 1 |
| 19 | Low oncogenic potential of avian endogenous RNA tumor virus infection or expression显示文摘 | MOTTA J V CRITTENDEN L B PURCHASE H G | 1975 | J Natl Cancer Inst1975，55，3： | 1 |
| 20 | Pollination, seed dispersal, seed germination and establishment of seedlings of Ficus microcarpa, Moraceae, in southeastern Brazil 显示文摘 | Figueiredo R A Motta Jr J C Vaseoneellos L A S | 1995 | Rev Brasil Biot1995，55，： | 1 |
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