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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Four decades of continuing innovation with fluorouracil:current and future approaches to fluorouracil chemoradiation therapy显示文摘 | RICH T A SHEPARD R C MOSLEY S T | 2004 | J Clin Oncol2004，22，11： | 1 |
| 3 | Effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | Eldredge E P Holmes Z A Mosley A R Shock C C Stieber T D | | 0，，： | 1 |
| 4 | Time course of diffusion imaging abnormalities in human stroke 显示文摘 | WARACH S MOSLEY M SORENSEN A G | 1996 | Stroke1996，27，7： | 1 |
| 5 | Can the FAST and ROSIER adult stroke recognition tools be applied to confirme child?hood arterial ischemic stroke显示文摘 | Y ock -Corrales A Babl FE Mosley IT | 2011 | BMC Pediatrics2011，，： | 1 |
| 6 | Highly activeanticancer curcumin analogues 显示文摘 | Mosley C A Liotta D C Snyder J P | 2007 | Adv Exp Med Biol2007，595，： | 1 |
| 7 | Helium Dynamics in Metal Tritides 2:The Sygnification of Microstructure in the Observed Helium Behavior for La-Ni-Al Tritides显示文摘 | Walters RT Nobile A Mosley WC | 1991 | J Less-Commom Metals1991，170，： | 1 |
| 8 | Folic acid and the decline in neural tube defects in Arkansas显示文摘 | MOSLEY B S HOBBS C A FLOWERS B S | | 0，，10： | 1 |
| 9 | Constraints to the potential impact of child survival in developing countries显示文摘 | Gadomski A Black R Mosley H | 1990 | Health Policy Plan1990，5，3： | 1 |
| 10 | Ivory Crisp: a potato variety with high tuber solids and cold chipping ability 显示文摘 | Love S L Mosley A R Novy R | 2003 | American Journal of Potato Research2003，80，： | 1 |
| 11 | Innate and adaptive immunity for the pathobiology of Parkinson's disease显示文摘 | Stone D K Reynolds A D Mosley R L | 2009 | Antioxid Redox Signal2009，11，： | 1 |
| 12 | Oxidative stress and the pathogenesis of neurodegenerative disorders显示文摘 | Reynolds A Laurie C Mosley RL | 2007 | Int Rev Neurobiol2007，82，： | 1 |
| 13 | Maitenance Scheduling and Staffing Policies in A Wafer Fabrication Facility显示文摘 | Mosley S A Teyner T Uzsoy R M | 1998 | IEEE Transactions Semiconductor Manufactory1998，11，： | 1 |
| 14 | Coherent supercontinuum generation in photonic crystal fiber with all- normal group velocity dispersion显示文摘 | Hooper L E Mosley P J Muir A C | 2011 | Optics Express2011，19，6： | 1 |
| 15 | The effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | ELDREDGE E P HOLMES Z A MOSLEY A R | 1996 | Am Potato J1996，73，： | 1 |
| 16 | Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study显示文摘 | Cheung N Mosley T Islam A | 2010 | Brain2010，133，7： | 1 |
| 17 | Plasma urate andParkinson ys disease in the Atherosclerosis Risk in Communities(ARIC ) study 显示文摘 | Chen H Mosley TH Alonso A | 2009 | American journal of epidemiology2009，169，9： | 1 |
| 18 | Methodology for the in vivo measure- ment of the dehag-desaturation of myristic, palmitic, and stearic acids in lactating dairy cattle显示文摘 | Mosley E E McGuire M A | 2007 | Lipids2007，42，： | 1 |
| 19 | Microglial neurotransmitter receptors trigger superoxide production in microglia;consequences for microglialneuronal interactions显示文摘 | Mead EL Mosley A Eaton S | | 0，，： | 1 |
| 20 | Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model 显示文摘 | Mach C M Mathew L Mosley S A | 2009 | Anticancer Res2009，29，6： | 1 |
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