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| 1 | 胶质瘤的基因治疗(英文)显示文摘Glioblastoma multiforme(GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as surgical resection followed by chemotherapy and radiotherapy.Unconventional treatment options such as gene therapy provide an intriguing option for curbing glioma related deaths.To date,gene therapy has yielded encouraging results in preclinical animal models as well as promising safety profiles in phase I clinical trials,but has failed to demonstrate significant therapeutic efficacy in phase III clinical trials.The most widely studied antiglioma gene therapy strategies are suicide gene therapy,genetic immunotherapy and oncolytic virotherapy,and we have attributed the challenging transition of these modalities into the clinic to four major roadblocks:(1) anatomical features of the central nervous system,(2) the host immune system,(3) heterogeneity and invasiveness of GBM and(4) limitations in current GBM animal models.In this review,we discuss possible ways to jump these hurdles and develop new gene therapies that may be used alone or in synergy with other modalities to provide a powerful treatment option for patients with GBM. | Tobias A Ahmed A Moon KS Lesniak MS. | 2013 | 中华神经外科疾病研究杂志2013，12，4： | 16 |
| 2 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 3 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 4 | Performance analysis of a simple vehicle detection algorithm显示文摘 | Moon H Chellappa R Rosenfeld A | 2002 | Image and Vision Computing2002，20，： | 2 |
| 5 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 6 | The FERET evaluation methodology for face-recognition algorithms显示文摘 | PHILLIPS P J MOON H RIZVI S A | 2000 | IEEE Transactions on PAM12000，22，10： | 1 |
| 7 | WNT and betacatenin signalling:diseases and therapies显示文摘 | Moon R T Kohn A D De Ferrari G V | 2004 | Nature Reviews Genetics2004，5，9： | 1 |
| 8 | Detection of viral RNA from paraffin-embedded tissues after prolonged formalin fixa-tion显示文摘 | McKinney M D Moon S J Kulesh D A | 2009 | J Clin Virol2009，44，1： | 1 |
| 9 | NDP kinase 2 regulates expression of antioxidant genes in arabidopsis显示文摘 | Yang K A Moon H Kim G | 2003 | Proceedings of the Japan Academy of Scieaces2003，79，3： | 1 |
| 10 | Auditor Tenure and Perceptions of Audit Quality 显示文摘 | Ghosh A Moon D | 2005 | The Accounting Review2005，80，02： | 1 |
| 11 | Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction显示文摘 | Wong Y Y Moon A Duffin R | 2010 | J Biol Chem2010，285，4： | 1 |
| 12 | Synergism between vascular growthendothelial faetor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions显示文摘 | Carmeliet P Moons L Luttun A | 2001 | Nat Med2001，7，5： | 1 |
| 13 | Application of fuzzy set theory for integration of geological, geophysical and remote sensing data 显示文摘 | An P Moon W M Rencz A | 1991 | Canadian Journal of Exploration Geophysics1991，27，： | 1 |
| 14 | Isolation and functional analysis of luxS in Serratia plymuthica RVHI显示文摘 | van HOUDT R MOONS P JANSEN A | 2006 | FEMS Microbiol Lett2006，262，2： | 1 |
| 15 | Determinants of Psy-chological Distress Over Time among Older Korean Im-migrant and Non-Hispanic White Elders Evidence from a Two-wave Panel Study显示文摘 | Min J W Moon A Lubben J E | 2009 | Aging Mental Health2009，9，3： | 1 |
| 16 | Transforming growth factor (TGF)-beta in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cells显示文摘 | Kim ES Kim MS Moon A | 2005 | Cytokine2005，29，2： | 1 |
| 17 | Fish Hepatocyte Phosphorylase-a Sensitive Indicator for Hormonal Modulation显示文摘 | Moon W T Busby G A Cooper D A | 1999 | Fish Physiology Biochemistry1999，21，： | 1 |
| 18 | The FERET evalua- tion methodology for face-recognition algorithms显示文摘 | Phillips P J Moon H Syed A | 2000 | IEEE Trans on Pattern Analysis and Machine InteUi- gence2000，22，10： | 1 |
| 19 | Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver显示文摘 | PARK S W MOON Y A HORTON J D | 2004 | J Biol Chem2004，279，50： | 1 |
| 20 | Molecular and physiological responses to abscisic acid and salt in roots of salt-sensitive and salt-tolerant indica rice varieties显示文摘 | Moons A G Bauw G Prinsen E | 1995 | Plant Physiology1995，35，： | 1 |
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