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| 1 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 2 | TWISTED DWARF 1 Associates with BRASSINOSTEROID-INSENSITIVE 1 to Regulate Early Events of the Brassinosteroid Signaling Pathway显示文摘为异种证明改变的 brassinosteroid (BR ) 敏感或象 bri1 一样显型导致了扭曲的矮子 1 的二新变异的等位基因(TWD1 ) 的鉴定的一幅染色体宽的屏幕, twd1-4,和 twd1-5。以前的研究显示了那 TWD1,也作为 ULTRACURVATA 2 或 FKBP42 说出,与植物生长素流出 transporters 联系并且为他们的生物功能是必要的。尽管更早的报告证明 BR 发信号是在 twd1 的 downregulated, TWD1 怎么集成于 BR 发信号,没被阐明。这里,我们提供证明 TWD1 以一种 BR 独立的方式与 BR 受体 BRI1 invivo 交往的基因、生物化学的证据。进一步的分析显示 TWD1 不由改变调制 BR 信号 transduction 嗯质量控制或蛋白质许多 BRI1;相反, TWD1 看起来在 BRI1 和它的合作受体的导致 BR 的相互作用批评这二蛋白质的 BAK1,以及导致 BR 的 phosphorylation。这些结果提供表明小径的 BR 的早事件的更好的理解。 | Baolin Zhao Minghui Lv Zengxiu Feng Thomas Campbell Emmanuel Liscum Jia Li | 2016 | Molecular Plant2016，9，4： | 8 |
| 3 | Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress显示文摘Background: Resveratrol, an important phyto-antioxidant commonly found in grapes, mulberry, and other plants,has a variety of functions including anti-aging, anti-cancer and anti-inflammatory activities. In the current study, we investigated the beneficial effects of resveratrol on in vitro porcine oocyte maturation under heat stress(HS). The effect of resveratrol, melatonin and their combination on alleviating HS was compared according to the maturation rate of oocytes and the development competence of embryos after parthenogenetic activation(PA).Results: Supplementation with resveratrol(2.0 μmol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos' PA from oocytes that underwent HS by increasing their glutathione(GSH)level, reducing reactive oxygen species(ROS) and up-regulating the expression of Sirtuin 1(SIRT1). It was also found that melatonin(10^(-7)mol/L) and the combination of resveratrol(2.0 μmol/L) plus melatonin(10^(-7)mol/L) exhibited more potent effects than resveratrol alone regarding their protective activities on oocyte maturation under HS.Conclusions: This study compared the efficiencies of resveratrol, melatonin and their combination for protecting porcine oocytes from heat stress. The mechanisms are attributed to the fact that each treatment may have different ability to regulate the synthesis of steroid hormones and the expression of mature related genes. | Yu Li Jing Wang Zhenzhen Zhang Jinyun Yi Changjiu He Feng Wang Xiuzhi Tian Minghui Yang Yukun Song Pingli He Guoshi Liu | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 7 |
| 4 | Microvascular pathological features and changes in related injury factors in a rat acute blood stasis model显示文摘OBJECTIVE: To examine the microvascular pathological characteristics and changes in related injury factors in a rat model of acute blood stasis.METHODS: A total of 75 Sprague-Dawley rats were divided randomly and equally into a control group and four experimental groups assessed at different times after the induction of stasis(0, 1, 3 or 6 h after stasis)(n = 15). The acute blood stasis model was established through rat tail-vein injection of high-molecular-weight dextran. After Electrocardiograph(ECG) detection at predetermined times(0,1, 3 and 6 h after induction of stasis), the rats were sacrificed and blood and cardiac samples were harvested for analysis. Hematoxylin-eosin(HE) staining and transmission electron microscopy were used for histopathological detection; an enzyme linked immunosorbent assay(ELISA) was used to detect thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-Keto-PGF1α) concentrations; a real-time polymerase chain reaction(PCR) reaction system was used to detect intercellular adhesion molecule1(ICAM-1) and vascular cell adhesion molecule1(VCAM-1) m RNA expression; western blotting was used to detect vascular endothelial cadherin(VE-cadherin) protein expression.RESULTS: The ST segment in the ECG showed gradual elevation after induction of stasis and continued elevation at a high level at 3 and 6 h. The HE staining showed changes in myocardial cell necrosis and tissue dissociation after the induction of stasis, along with inflammatory infiltration. Results of transmission electron microscopy showed immediate changes in blood stasis and lumen occlusion in the microvasculature, along with endothelial cell swelling. After the induction of stasis, TXB2 concentrations gradually increased while 6-Keto-PGF1αconcentrations were immediately significantly reduced. The TXB2/6-Keto-PGF1αratio was maintained at a high level. ICAM-1 m RNA expression showed an unstable elevation while VCAM-1 m RNA expression was significantly reduced after the induction of stasis. Compared with the control group, VE-cadherin protein expression increased at 0 and 3 h after the induction of stasis, while no change occurred at 1 and 6 h.CONCLUSION: The pathological manifestations of acute blood stasis are microvascular blood retention, lumen stenosis and even occlusion. The condition is also called 'blood coagulation and weep' in Traditional Chinese Medicine. The blood stasis model resulted in the injury and necrosis of endothelial cells and cardiomyocytes, along with the presence of an imbalance of vasomotor factor levels, platelet activation, and increases in the expression of adhesion molecules and endothelial barrier dysfunction,which corresponds to 'blood failed to nourish' in Traditional Chinese Medicine. | Zhang Junxiu Feng Yu Li Shaodan, Liu Yi Zhang Yin Guo Yunxia Yang Minghui | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 5 |
| 5 | TanshinoneⅡA improves distribution and anti-tumor efficacy of pegylated liposomal doxorubicin via normalizing the structure and function of tumor vasculature in hepa1-6 hepatoma mice model显示文摘OBJECTIVE: To investigate whether the Tandistribution and anti-tumor Ⅱef A could improve the ficacy of Pegylated Liposomal Doxorubicin(PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatoma mice model.METHODS: Hepa1-6 hepatoma-bearing mice were treated with TanⅡA for 14 d. Distribution and anti-tumor efficacy of PLD, and the structure and function of the tumor vasculature were evaluated using various techniques.RESULTS: TanⅡ A significantly reduced the micro-vessel density(MVD). After Tan vascular walls were betteⅡr s A treatment,the tumor tructured, as the increased coverage of the pericytes and the promoted contact of the basement membrane and endothelial cell. Functional tests showed that tumor hypoxia was improved and the exudation amount of Evans blue in the parenchyma of the tumor decreased. In addition, mice treated with TanA had greater PLD penetration distance intratumoⅡrally. Furthermore, combined therapy of Tanibited tumor growth.ⅡA and PLD significantly inhCONCLUSION: This study suggests that Tanasculature andⅡ h A helps normalizing the tumor vas therapeutic potential in increasing the distribution of chemotherapy drug in the tumor. | Zhang Ying Tie MingHui Bi Feng Wang Ke | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 4 |
| 6 | An in-situ formed ceramic/alloy/ceramic sandwich barrier to resist elements interdiffusion between NiCrAlY coating and a Ni-based superalloy显示文摘NiCrAlY coatings are widely applied on various alloy components to enhance oxidation and/or corrosion resistance at high temperatures.However,elements interdiffusion occurs between them due to composition difference.Although various diffusion barriers(DBs)are reported,this problem is still far from completely solved as most ceramic barriers suffer from poor adherence,while the metallic barriers play a limited role.In this study,NiCrAlY coating was deposited onto a second-generation single-crystal superalloy by arc ion plating.A novel simple method is provided to address elements interdiffusion.By pre-oxidation at a moderate temperature,a thin scale of Ni(Co)O forms at the alloy surface.It transforms to be an alumina/NiCoCr alloy/alumina sandwich by an in-situ reaction with the overlaying NiCrAlY coating and the alloy substrate at high service temperatures,which offers good barrier ability in conjunction with strong adhesion.In the presence of such an alumina/alloy/alumina DB,the NiCrAlY coating provides high resistance to oxidation and scale spallation for the alloy substrate. | Cean Guo Feng Zhou Minghui Chen Jinlong Wang Shenglong Zhu Fuhui Wang | 2021 | Journal of Materials Science & Technology2021，，11： | 3 |
| 7 | Changes in nitric oxide,angiotensinⅡ,angiopoietin-like protein 4 mRNA,neuregulin 1 mRNA,and platelet endothelial cell adhesion molecule-1 in rats with acute blood stasis induced by high-molecular-weight dextran显示文摘OBJECTIVE: To investigate the influence of acute blood stasis on nitric oxide(NO), angiotensin Ⅱ(Ang Ⅱ), angiopoietin-like protein 4(ANGPTL4)m RNA, neuregulin 1(NRG-1) m RNA, and platelet endothelial cell adhesion molecule-1(PECAM-1) in rats with stasis induced by high-molecular-weight dextran(HMWD).METHODS: Seventy-five Sprague Dawley rats were divided randomly into five groups(n = 15 in each group): control group, immediate group, 1 h group,3 h group, and 6 h group. A model of acute blood stasis was established via injection of HMWD into the tail vein. After performing electrocardiogram at the predetermined times according to the grouping, we collected blood and cardiac samples for hematoxylin-eosin(HE) staining and histopathological examination via transmission electron microscopy. Enzyme-linked immunosorbent assay was used to detect plasma levels of NO, AngⅡ, and fibrinogen. Real-time polymerase chain reaction was used to detect the expression of ANGPTL4 m RNA and NRG-1 m RNA. Immunohistochemical methods were used to detect PECAM-1 protein expression.RESULTS: The rat model of blood stasis showed blood retention in the capillary lumens. The ST segment showed gradual elevation, and was still elevated at 3 and 6 h after induction of blood stasis.HE staining showed myocardial cell necrosis and dissolution after modeling, along with basement membrane rupture and mitochondrial structural damage. Transmission electron microscopy showed endothelial cell swelling and an increase in absorption vesicles immediately after modeling. Endothelial cell apoptosis was increased at 3 and 6 h after modeling. Cardiac muscle fibers were disordered and intercalated discs were blurred immediately after modeling. There were massive numbers of dissolved cardiac muscle fibers, ruptured basement membranes, and mitochondrial structural damage at 3 and 6 h after modeling. NO plasma concentration was significantly reduced immediately and 1 h after modeling, while it was increased at 3 and 6 h.AngⅡ plasma concentration was decreased immediately after modeling, but increased at 1, 3, and6 h. Fibrinogen plasma concentration was significantly increased at immediate, 1, 3, and 6 h after modeling. PECAM-1 protein expression was obviously increased immediately after modeling, at 1, 6 h was found mild augment. Expression of Ang PTL4 m RNA was increased at immediate, 1, 3, and 6 h after modeling, and was found further augment at 3,and 6 h. Expression of NRG-1 m RNA was increased at immediate, 1, 3, and 6 h after modeling, and the strongest expression was at 1 h.CONCLUSION: The pathological manifestation of acute blood stasis is characterized by microvascular blood retention. Prolonged blood stasis leads to worsening endothelial cell and cardiomyocyte damage, along with imbalances in the expression of vasomotor factors and increased vascular tone.The pathological damage caused by blood stasis also promotes the expression of cell protection factors. | Feng Yu Zhang Junxiu Li Shaodan Liu Yi Zhang Yin Guo Yunxia Yang Minghui | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 8 | Protein farnesylation negatively regulatesbrassinosteroid signaling via reducing BES1 stabilityinArabidopsis thaliana^(∞)显示文摘Brassinosteroids(BRs)are a group of steroidal phytohormones,playing critical roles in almost all physiological aspects during the life span of a plant.In Arabidopsis,BRs are perceived at the cell surface,triggering a reversible phosphorylation-based signaling cascade that leads to the activation and nuclear accumulation of a family of transcription factors,represented by BES1 and BZR1.Protein famesylation is a type of post-translational modification,functioning in many important cellular processes.Previous studies demonstrated a role of famesylation in BR biosynthesis via regulating the endoplasmic reticulum localization of a key bassino-lide(BL)biosynthetic enzyme BR6ox2.Whether such a process is also involved in BR signaling is not understood.Here,we demonstrate that protein famesylation is involved in mediating BR signaling in Arabidopsis.A loss-of-function mutant of EN HANCED RESPONSE TO ABA 1(iERA1).encoding a(3 subunit of the protein famesyl transferase hoi oenzyme,can alter the BL sensitivity of bak1~4 from a reduced to a hypersensitive level,era 7 can partially rescue the BR defective phenotype of a hetero zygous mutant of bin2-1,a gain-of function mutant of BIN2 which encodes a negative regulator in the BR signaling.Our genetic and biochemical analyses revealed that ERA1 plays a significant role in regulating the protein stability of BES1. | Zengxiu Feng Hongyong Shi Minghui Lv Yuang Ma Jia Li | 2021 | Journal of Integrative Plant Biology2021，63，7： | 3 |
| 9 | Identification of Molecular Subtypes of Gastric Cancer with Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil显示文摘 | Zhengdeng Lei Iain Beehuat Tan Kakoli Das Niantao Deng Hermioni Zouridis Sharon Pattison Clarinda Chua Zhu Feng Yeoh Khay Guan Chia Huey Ooi Tatiana Ivanova Shenli Zhang Minghui Lee Jeanie Wu Anna Ngo Sravanthy Manesh Elisabeth Tan Bin Tean Teh Jimmy Bok | 2013 | Gastroenterology2013，，： | 2 |
| 10 | Elevated expression of lung development-related protein HSP9O0 indicates poor prognosis in non-small cell lung cancer through affecting the cell cycle and apoptosis显示文摘Dear Editor,Oncogenesis was considered to be similar to the early embryonic development process in a variety of ways.1 Using normal development samples as research models will help us understand tumors and identify potential biomarkers.Heat-shock protein 90 beta(HSP90P,HSP90AB1)is one of the major isoforms of HSP90 and is involved in embryonic development,signal transduction,and cellular adaptability. | Xiang Wang Yaru Wang Lin Feng Minghui Wang Kaitai Zhang Yousheng Mao Ting Xiao Shujun Cheng | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 11 | Four-protein model for predicting prognostic risk of lung cancer显示文摘Patients with lung cancer at the same stage may have markedly different overall outcome and a lack of specific biomarker to predict lung cancer outcome.Heat-shock protein 90β(HSP90β)is overexpressed in various tumor cells.In this study,the ELISA results of HSP90βcombined with CEA,CA125,and CYFRA21-1 were used to construct a recursive partitioning decision tree model to establish a four-protein diagnostic model and predict the survival of patients with lung cancer.Survival analysis showed that the recursive partitioning decision tree could distinguish the prognosis between high-and low-risk groups.Results suggested that the joint detection of HSP90β,CEA,CA125,and CYFRA21-1 in the peripheral blood of patients with lung cancer is plausible for early diagnosis and prognosis prediction of lung cancer. | Xiang Wang Minghui Wang Lin Feng Jie Song Xin Dong Ting Xiao Shujun Cheng | 2022 | Frontiers of Medicine2022，16，4： | 2 |
| 12 | Phase structure of sputtered Ta coating and its ablation behavior by laser pulse heating(LPH)显示文摘Phase structure of sputtered Ta coating in the negative glow space and LPH effect were explored.The whole coating/substrate system is substrate→physically gas-absorbed Fe surface→oxygen-enriched TaOx layer→amorphous Ta→αandβdual phase→singleαphase.After LPH course,micro structure of Ta coating shows intact,only a few cracks emerge after 100 laser pulses,exhibiting thin HAZ but thick Fe/Ta ICZ,without martensitic transformation.For the electrodeposited Cr coating,continuous thermal stresses produce many extra micro-crack,substrate oxidation and martensitic transformation,leading to crack propagations and final bulk delamination,without any ICZ. | Yunsong Niu Lingling Xing Feng Yang Huawei Li Minghui Chen Shenglong Zhu Fuhui Wang | 2021 | Journal of Materials Science & Technology2021，，6： | 2 |
| 13 | The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo显示文摘1,2,3,7,8-PeCDD 被腹注射管理到少年金鱼(Carassius auratus ) 探索尖锐致命性和 1,2,3,7,8-PeCDD 体内的内分泌的效果。1,2,3,7,8-PeCDD 的尖锐中部的致命的剂量(LD50 ) 的价值在尖锐致命性测试被决定。1,2,3,7,8-PeCDD 的内分泌的效果,谁的暴露了集中,基于 LD50 (1.84 mg/kg ) 被决定,被测量血浆卵黄蛋白原(Vtg ) 学习在有连接酶的免疫吸着剂试金(ELISA ) 的少年男性金鱼的内容。由于它在一个星期在 1/2LD50 和 LD30 组的暴露体内以后的血浆 Vtg 的重要正式就职, 1,2,3,7,8-PeCDD 可能是到在环境的 PCDD 的雌激素的效果的重要贡献者之一。1/2 LD50 和 LD30 的价值在 1,2,3,7,8-PeCDD 的有效剂量的范围以内,显示在雌激素的有效剂量和 LD50 之间有某个关系。 | YANG Yongbin LIU Zhengtao ZHENG Minghui ZHAO Yanyan WANG Liang SUN Wei XIAO Feng | 2008 | Journal of Environmental Sciences2008，20，2： | 2 |
| 14 | Journal of Membrane Science显示文摘 | Feng Jun Qiu Minghui Fan Yiqun | 2007 | 305:202007，305，： | 1 |
| 15 | Benefits of Zr addition to oxidation resistance of a single-phase (Ni,Pt)Al coating at 1373 K显示文摘A single-phase (Ni,Pt)Al coating with lean addition of Zr was prepared by co-electroplating of Pt-Zr com posite plating and subsequent gaseous alum inization treatm ents. Isotherm al and cyclic oxidation behavior of the Zr-doped (Ni,Pt)Al coating sam ples was assessed at 1373K in static air in comparison with plain nickel alum inide (NiAl) and norm al (Ni,Pt)Al coatings. Results indicated th at Zr-doped (Ni,Pt)Al coating dem onstrated a lower oxidation rate constant and reduced tendency of oxide scale spallation as well as surface rumpling, in which the enhanced oxidation perform ance was m ainly attributed to the segregation of Zr at oxide scale grain boundaries and the im proved Young's modulus of the coating. Besides, the addition of Zr effectively delayed oxide phase transform ation of Al2O3 from θ phase to α phase in the early oxidation stage and coating degradation of β-NiAl to γ'-Ni3Al in the stable oxidation stage. | Chengyang jiang Lingyi Qian Min Feng He Liu Zebin Bao Minghui Chen Shenglong Zhu Fuhui Wang | 2019 | Journal of Materials Science & Technology2019，35，7： | 1 |
| 16 | Analyte-Induced Aggregation of a Water-Soluble Conjugated Polymer for Fluorescent Assay of Oxalic Acid显示文摘 | Sun Huan Feng Fude Yu Minghui | | 0，，18： | 1 |
| 17 | Mechanism and operation parameters of a plasma-driven micro-particle accelerator显示文摘There is a large amount of micro debris ranging between millimeters and micrometers in space, which has significant influence on the reliability and life of spacecrafts through long-duration integrated impacts and has to be considered in designing a vehicle's suitability to the space environment. In order to simulate the micro-impacts on exposed materials, a plasma-driven micro-particle accelerator was developed. The major processes, including the acceleration, compression and ejection of plasmas, were modeled. By comparing the theoretical simulations with the experimental results, the acceleration mechanism was clarified. Moreover, through a series of experiments, the optimum operation range was investigated, and the acceleration ability was primarily determined. | HUANG JianGuo HAN JianWei LI HongWei CAI MingHui LI xiaoYin ZHANG ZhenLong CHEN ZhaoFeng WANG Long YANG XuanZong FENG ChunHua | 2009 | Chinese Science Bulletin2009，54，4： | 1 |
| 18 | Phononic crystals and acoustic metamaterials显示文摘 | Lu Minghui Liang Feng Chen Yanfeng | 2009 | Materials Today2009，，12： | 1 |
| 19 | Near-field acoustic levitation and applications to bearings:a critical review显示文摘The importance to industry of non-contact bearings is growing rapidly as the demand for highspeed and high-precision manufacturing equipment increases.As a recently developed non-contact technology,near-field acoustic levitation(NFAL)has drawn much attention for the advantages it offers,including no requirement for an external pressurized air supply,its compact structure,and its ability to adapt to its environment.In this paper,the working mechanism of NFAL is introduced in detail and compared to all existing non-contact technologies to demonstrate its versatility and potential for practical applications in industry.The fundamental theory of NFAL,including gas film lubrication theory and acoustic radiation pressure theory is presented.Then,the current stateof-the-art of the design and development of squeeze film air bearings based on NFAL is reviewed.Finally,future trends and obstacles to more widespread use are discussed. | Minghui Shi Kai Feng Junhui Hu Jiang Zhu Hailong Cui | 2019 | International Journal of Extreme Manufacturing2019，1，3： | 1 |
| 20 | 显示文摘 | Feng Jun Qiu Minghui Fan Yiqun | 2007 | Journal of Membrane Science2007，305，： | 1 |
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