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| 1 | Male infertility: lifestyle factors and holistic, complementary, and alternative therapies显示文摘当我们可能与男不孕的一条对症疗法的途径是舒适的时,我们为生活方式修正和被许多我们的病人使用的整体、互补、其他的治疗的知识也负责。这份报纸提供为几这些治疗把事实与小说分开的基于证据的评论。有足够的文学由饮食和锻练支持重量减小,吸停止,和白酒中等。在小使随机化的控制试用(RCT ) 上在男富饶上表明了积极效果的补充包括 aescin,辅酶 Q 10, 谷胱甘肽,朝鲜红人参, L 肉毒碱, nigella sativa, omega-3,硒,锌的联合并且叶酸,并且 Menevit 抗氧化剂。对维生素 C,维生素 E,或藏花的使用没有支持。为中国草药的药的数据,针灸,头脑身体实践,阴囊的冷却,并且基于信心的愈合稀少或不确定。 | David F Yao Jesse N Mills | 2016 | Asian Journal of Andrology2016，18，3： | 11 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 4 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 5 | Calpain activity in the rat brain after transient forebrain ischemia 显示文摘 | NEUMAR R W MENG F H MILLS A M | 2001 | Exp Neurol2001，170，1： | 1 |
| 6 | Wireless endoscopy显示文摘 | Gong F Swain P Mills T | 2000 | Gatrointestinal Endoscopy2000，51，6： | 1 |
| 7 | The keystone species concept in ecology and conservation显示文摘 | MILLS L S SOULE M E DOAK D F | 1993 | Biol Science1993，43，2： | 1 |
| 8 | SNS-595, a naphthyridine cell cycle inhibitor and stimulator of apoptosis for the treatment of cancers显示文摘 | Mills D A Fekrazad H M Verschraegen C F | 2008 | Current Opinion in Investigational Drugs2008，9，6： | 1 |
| 9 | Effect of polymerization on particle morphology in heterogeneous systems显示文摘 | MILLS M F GIBERT R G NAPPER D H | 1990 | Macromolecules1990，，23： | 1 |
| 10 | The fine structure obliquely striated body wall muscles in the earthworm,Lumbricus terrestris显示文摘 | Knapp M F | 1970 | Journal of Cell Science1970，，7： | 1 |
| 11 | Kinetics and mechanisms of kaolinite dissolution:effects of organic ligands 显示文摘 | Chin P K F Mills G L | 1991 | Chemical Geology1991，90，： | 1 |
| 12 | The condensation coefficient of water 显示文摘 | Mills A F Seban R A | 1967 | International Journal of Heat and Mass Transfer1967，10，12： | 1 |
| 13 | Ultrasonic phased array contribution to the knowledge of the flow fusion weIding process used to make the Roman large bronze statues显示文摘 | A Azema F Angelini B Mille | 2013 | Welding in the World2013，57，4： | 1 |
| 14 | Gold as a Hedge against US Dollar显示文摘 | Capie F T. Mills G. Wood | | 0，，30： | 1 |
| 15 | Last-Chance Earnings Management: Using the Tax Expense to Meet Analysts' Forecasts 显示文摘 | Dhaliwal D S Gleason C A Mills L F | 2004 | Contemporary Accounting Research2004，21，02： | 1 |
| 16 | Direct profiling of the yeast dynamics in wine fermentations 显示文摘 | Cocolin L Bisson L F Mills D A | 2000 | FEMS Microbi- ology Letters2000，189，1： | 1 |
| 17 | The fine structure obliquely striated body wall muscles in the earthworm,Lumbricus terrestri 显示文摘 | Knapp M F | 1970 | Journal of Cell Science1970，，7： | 1 |
| 18 | Moisture transport in silica gel packed beds显示文摘 | Pesaran A A Mills A F | 1987 | Int J Heat Mass Transfer1987，30，： | 1 |
| 19 | The Patched dependencereceptor triggers apoptosis through a DRAL-caspase-9 complex显示文摘 | Mille F Thibert C Fombonne J | 2009 | Nat Cell Biol2009，11，6： | 1 |
| 20 | Upper urinary tract tumors after primary superficial bladder tumors:prognostic factors and risk groups显示文摘 | Millán-Rodrigues F Chéchile-Toniolo G Salvador-Bayarri J | 2000 | J Urol2000，164，4： | 1 |
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