|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 3 |
| 2 | LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease显示文摘Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD. | Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 3 | Preparation and properties of plasticized starch modified with poly( e-caprolactone) based waterborne polyurethane显示文摘 | Xiaodong Cao Peter R Chang Michel AHuneault | 2008 | Carbohydrate Polymers2008，，71： | 1 |
| 4 | Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome显示文摘 | Israr Ahmad Kashiff M. Muneer Iman A. Tamimi Michelle E. Chang Muhammad O. Ata Nabiha Yusuf | 2013 | Toxicology and Applied Pharmacology2013，，： | 1 |
| 5 | Plasma membrane Ca^sup 2+^-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents显示文摘 | Wu Xu Chang Baojun Blair N Scott Sargent Michelle York Allen J Robbins Jeffrey Shull Gary E Molkentin Jeffery D | 2009 | Journal of Clinical Investigation2009，，4： | 1 |
| 6 | Site-specific gene insertion mediated by a Cre-loxP-carrying lentiviral vector 显示文摘 | Michel G Yu Y Chang T | 2010 | Mol Ther2010，18，18： | 1 |
| 7 | Haemophilus influenzae vaccine candidate outer membrane protein 1'6 is not conserved in all strains 显示文摘 | Chang A Kaur R Michel LV | 2011 | Hum Vaccine2011，7，1： | 1 |
| 8 | Carrier dynamics and doping profiles in GaAs nanosheets显示文摘 | Chia-Chi Chang Chun-Yung Chi Chun-Chung Chen Ningfeng Huang Shermin Arab Jing Qiu Michelle L. Povinelli P. Daniel Dapkus Stephen B. Cronin | 2014 | Nano Research2014，7，2： | 1 |
| 9 | Functional MRI of Language in Aphasia: A Review of the Literature and the Methodological Challenges显示文摘 | Bruce Crosson Keith McGregor Kaundinya S. Gopinath Tim W. Conway Michelle Benjamin Yu-Ling Chang Anna Bacon Moore Anastasia M. Raymer Richard W. Briggs Megan G. Sherod Christina E. Wierenga Keith D. White | 2007 | Neuropsychology Review2007，，2： | 1 |
| 10 | Size of regional trade agreements and regional trade bias显示文摘 | Michele Fratianni Chang Hoon Oh | 2009 | Applied Economics Letters2009，，16： | 1 |
| 11 | Site-specific gene inser- tion mediated by a Cre-loxP-carrying lentiviral vector显示文摘 | Michel G Yu Y Chang T | 2010 | Mol Ther2010，18，10： | 1 |
| 12 | Thedevelopment of an integrated and intelligent CAD/CAPP/CAFP environment using logic-based reasoning 显示文摘 | Jerry Y H Fuh Ghao-Hwa Chang Michel A Melkanoff | 1996 | Com-puter Aided Design1996，28，3： | 1 |
| 13 | Preparation and properties of plasticized starch modified with poly( e-caprolactone) based waterborne polyurethane 显示文摘 | Cao Xiao-dong Chang Peter R Michel A | 2008 | Carbohydrate Polymers2008，，71： | 1 |
| 14 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
| 15 | Ranpirnase(frog RNase)targeted with a humanized,internalizing,anti- Trop-2 antibody has potent cytotoxicity against diverse epi- thelial cancer cells显示文摘 | Chang CH Gupta P Michel R | 2010 | Mol Cancer Ther2010，9，： | 1 |
| 16 | Site-speci/i gene in- sertion mediated by a Cre-LoxP-earrying lentiviral vector显示文摘 | Michel G Yu Y Chang T | 2010 | Molecular Therapy2010，18，10： | 1 |
| 17 | Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus显示文摘AIM: To determine the safety profile of new hepatitis C virus(HCV) treatments in liver transplant(LT) recipients with recurrent HCV infection.METHODS: Forty-two patients were identified with recurrent HCV infection that underwent LT at least 12 mo prior to initiating treatment with a Sofosbuvir-based regimen during December 2013-June 2014. Cases were patients who experienced hepatic decompensation and/or serious adverse events(SAE) during or within one month of completing treatment. Controls had no evidence of hepatic decompensation and/or SAE. HIVinfected patients were excluded. Cumulative incidence of decompensation/SAE was calculated using the Kaplan Meier method. Exact logistic regression analysis was used to identify factors associated with the composite outcome. RESULTS: Median age of the 42 patients was 60 years [Interquartile Range(IQR): 56-65 years], 33%(14/42) were female, 21%(9/42) were Hispanic, and 9%(4/42) were Black. The median time from transplant to treatment initiation was 5.4 years(IQR: 2.1-8.8 years). Thirteen patients experienced one or more episodes of hepatic decompensation and/or SAE. Anemia requiring transfusion, the most common event, occurred in 62%(8/13) patients, while 54%(7/13) decompensated. The cumulative incidence of hepatic decompensation/SAE was 31%(95%CI: 16%-41%). Risk factors for decompensation/SAE included lower pre-treatment hemoglobin(OR = 0.61 per g/d L, 95%CI: 0.40-0.88, P < 0.01), estimated glomerular filtration rate(OR = 0.95 per m L/min per 1.73 m^2, 95%CI: 0.90-0.99, P = 0.01), and higher baseline serum total bilirubin(OR = 2.43 per mg/d L, 95%CI: 1.17-8.65, P < 0.01). The sustained virological response rate for the cohort of 42 patients was 45%, while it was 31% for cases.CONCLUSION: Sofosbuvir/ribavirin will continue to be used in the post-transplant population, including those with HCV genotypes 2 and 3. Management of anemia remains an important clinical challenge. | Neal Patel Kian Bichoupan Lawrence Ku Rachana Yalamanchili Alyson Harty Donald Gardenier Michel Ng David Motamed Viktoriya Khaitova Nancy Bach Charissa Chang Priya Grewal Meena Bansal Ritu Agarwal Lawrence Liu Gene Im Jennifer Leong Leona Kim-Schluger Joseph Odin Jawad Ahmad Scott Friedman Douglas Dieterich Thomas Schiano Ponni Perumalswami Andrea Branch | 2016 | World Journal of Gastroenterology2016，22，9： | 1 |
| 18 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 1 |
| 19 | Using distributed objects to build the Stanford digital library InfoBus 显示文摘 | Michelle Q W Chang Chen-Chuan K | 1999 | IEEE Computer1999，32，2： | 1 |
| 20 | Exploring bacterial lignin degradation显示文摘 | Margaret E Brown Michelle CY Chang | 2014 | Current Opinion in Chemical Biology2014，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员