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| 1 | Runtime software architecture based on reflective middleware显示文摘There exists a consensus that software architecture (SA) plays a central role in software development and also plays an important role in the lifecycle phases after software delivery. Particularly, SA can be used to reduce the great difficulty and cost of software maintenance and evolution. In this paper, runtime software architecture (RSA) based on reflective middleware is proposed to support architecture-based software maintenance and evolution. In this approach, the actual states and behaviors of the runtime system can be observed and manipulated in a consistent and understandable way through its architectural view. Being an accurate, up-to-date, semantic and operable view of SA, RSA looks components and connectors as white-box entities to accurately and thoroughly describe the runtime system, extends traditional architecture description languages to formally describe itself and naturally inherit plentiful semantics in traditional views of SA, and utilizes reflective middleware to observe and manipulate the runtime system. In order to demonstrate the feasibility of this approach, a reflective J2EE application server, called PKUAS, is implemented to observe and manipulate the components, connectors and constraints in the runtime system. Finally, the performance evaluation proves that making RSA explicit and operable at runtime has little effect on the runtime system. | HUANGGang MEIHong YANGFuqing | 2004 | Science in China(Series F)2004，47，5： | 18 |
| 2 | Drag prediction method of powered-on civil aircraft based on thrust drag bookkeeping显示文摘A drag prediction method based on thrust drag bookkeeping(TDB) is introduced for civil jet propulsion/airframe integration performance analysis.The method is derived from the control volume theory of a powered-on nacelle.Key problem of the TDB is identified to be accurate prediction of velocity coefficient of the powered-on nacelle.Accuracy of CFD solver is validated by test cases of the first AIAA Propulsion Aerodynamics Workshop.Then the TDB method is applied to thrust and drag decomposing of a realistic aircraft.A linear relation between the computations assumed free stream Mach number and the velocity coefficient result is revealed.The thrust losses caused by nozzle internal drag and pylon scrubbing are obtained by the isolated nacelle and mapped on to the in-flight whole configuration analysis.Effects of the powered-on condition are investigated by comparing through-flow configuration with powered-on configuration.The variance on aerodynamic coefficients and pressure distribution is numerically studied. | Zhang Yufei Chen Haixin Fu Song Zhang Miao Zhang Meihong | 2015 | Chinese Journal of Aeronautics2015，28，4： | 11 |
| 3 | A comparative study of MEA and DEA for post-combustion CO2 capture with different process configurations显示文摘 | Boyang Xue Yanmei Yu Jian Chen Xiaobo Luo Meihong Wang | 2017 | International Journal of Coal Science & Technology2017，4，1： | 11 |
| 4 | Current status and future development of solvent-based carbon capture显示文摘 | Eni Oko Meihong Wang Atuman S. Joel | 2017 | International Journal of Coal Science & Technology2017，4，1： | 10 |
| 5 | Image Segmentation Based on Modified Pulse-Coupled Neural Networks显示文摘 | ZHANG Junying FAN Xiuju DONG Jiyang SHI Meihong | 2007 | Chinese Journal of Electronics2007，16，1： | 6 |
| 6 | Synthesis of mesoporous nano-TiO_(2)doped with Sn by auto-assembly method and photo-catalytic property显示文摘A series of mesoporous nano-TiO2 material doped with Sn are synthesized by a homogenous precipitation method aided by microwave heating, using TiCl4 and SnCl4 as raw materials, urea as precipitator, active carbon as templet, and soluble starch as anti- agglomer-ating reagent. XRD results show that the precursor exists in the amorphous phase, and trans-forms to anatase structure above 400℃. TEM results show that the particle is in spherical shape and the average diameter is 20 nm. EDS results show that the measuring value of compound is in accord with the actual value of the raw materials, and the doping uniformity is good. The photo-catalytic experimental results show that the highest photo-catalytic efficiency can be ob-tained when the content of Sn is 10% (mol pecent), and the decolorization rate of navy blue dye can be as high as 100% after being illuminated by sunlight for 70 min. The photo-catalytic reac-tion is a first-order kinetic reaction. | ZHANG Meihong DING Shiwen WANG Zhenxing ZHANG Yuzhuo | 2005 | Science China Chemistry2005，48，5： | 4 |
| 7 | The Genomes of the Allohexaploid Echinochloa crus-galli and Its Progenitors Provide Insights into Polyploidization-Driven Adaptation显示文摘The hexaploid species Echinochloa crus-galli is one of the most detrimental weeds in crop fields,especially in rice paddies.Its evolutionary history is similar to that of bread wheat,arising through polyploidization after hybridization between a tetraploid and a diploid species.In this study,we generated and analyzed high-quality genome sequences of diploid(E.haploclada),tetraploid(E.oryzicola),and hexaploid(E.crus-galli)Echinochloa species.Gene family analysis showed a significant loss of disease-resistance genes such as those encoding NB-ARC domain-containing proteins during Echinochloa polyploidization,contrary to their significant expansionduring wheat polyploidization,suggesting that natural selection might favor reduced investment in resistance in this weed to maximize its growth and reproduction.In contrast to the asymmetric patterns of genome evolution observed in wheat and other crops,no significant differences in selection pressure were detected between the subgenomes in E.oryzicola and E.crus-galli.In addition,distinctive differences in subgenome transcriptome dynamics during hexaploidization were observed between E.crus-galli and bread wheat.Collectively,our study documents genomic mechanisms underlying the adaptation of a major agricultural weed during polyploidization.The genomic and transcriptomic resources of three Echinochloa species and new insights into the polyploidization-driven adaptive evolution would be useful for future breeding cereal crops. | Chu-Yu Ye Dongya Wu Lingfeng Mao Lei Jia Jie Qiu Sangting Lao Meihong Chen Bowen Jiang Wei Tang Qiong Peng Lang Pan Lifeng Wang Xiaoxiao Feng Longbiao Guo Chulong Zhang Elizabeth A.Kellogg Kenneth M.Olsen Lianyang Bai Longjiang Fan | 2020 | Molecular Plant2020，13，9： | 4 |
| 8 | Synthesis of taurine-fluorescein conjugate and evaluation of its retina-targeted efficiency in vitro显示文摘In this work, retinal penetration of fluorescein was achieved in vitro by covalent attachment of taurine to fluorescein, yielding the F-Tau conjugate. Nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) were used to confirm the successful synthesis of F-Tau. The cellular uptake of F-Tau in adult retinal pigment epithelial cells (ARPE-19) and human retinal microvascular endothelial cells (hRMECs) was visualized via confocal scanning microscopy. The results indicated an improvement of solubility and a reduction of logP of F-Tau compared with fluorescein. As compared with fluorescein, F-Tau showed little toxicity, and was retained longer by cells in uptake experiments. F-Tau also displayed higher transepithelial permeabilities than fluorescein in ARPE-19 and hRMECs monolayer cells (Po0.05). These results showed that taurine may be a useful ligand for targeting small-molecule hydrophobic pharmaceuticals into the retina. | Meihong Huang Jiaqi Song Bingzheng Lu Huizhi Huang Yizhen Chen Wei Yin Wenbo Zhu Xinwen Su Chuanbin Wu Haiyan Hu | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 4 |
| 9 | Measurement-device-independent quantum secret sharing and quantum conference based on Gaussian cluster state显示文摘Cluster state is the basic resource for one-way quantum computation and a valuable resource for establishing quantum network, because it has a flexible and varied composition form. We present measurement-device-independent quantum secret sharing(QSS) and quantum conference(QC) schemes based on continuous variable(CV) four-mode cluster state with different structures. The users of the protocol prepare their own Einstein-Podolsky-Rosen(EPR) states, respectively. One mode of these EPR states is sent to an untrusted relay where a generalized Bell measurement creates different types of CV cluster states among four users, while the other mode is kept at their own station. We show that a shared secret key for QSS and QC schemes is distilled based on the shared quantum correlation among four users. QC and four users QSS are implemented based on the star shape CV cluster state. QSS with three users are implemented based on the linear or square shape CV cluster states. The results show that the secure transmission distance for an asymmetric network, where the transmission distances between the users and relay are different, is longer than that of a symmetric network, where the transmission distances between the users and relay are the same. The presented schemes provide concrete references for establishing quantum network with the CV cluster state. | Yu WANG Caixing TIAN Qi SU Meihong WANG Xiaolong SU | 2019 | Science China(Information Sciences)2019，62，7： | 4 |
| 10 | Molecular Cloning and Expression Analysis of a Hexokinase Gene,MdHXK1 in Apple显示文摘A hexokinase gene named MdHXK1(MDP0000309677) was cloned from ‘Gala' apple(Malus × domestica Borkh.). Sequence analysis showed that the MdHXK1 gene was 1 497 bp long and encoded 499 amino acids. The predicted molecular mass of this protein was 54.05 kD, and the pI was 5.76. A phylogenetic tree indicated apple MdHXK1 exhibited the highest sequence similarity to Pyrus bretschneideri PbHXK1. Analysis of the functional domain showed that the MdHXK1 protein included two conserved kinase domains. The prediction of subcellular localization suggested that the MdHXK1 protein was mainly localized in the cytoplasm. There was an indication that MdHXK1 existed as one copy in the apple genome by Southern blotting. Silico analysis suggested that the promoter sequence contained several typical cis-acting elements, including defense, sugar signaling and phytohormone responsive elements. Quantitative real-time PCR analysis demonstrated that the MdHXK1 gene was mainly expressed in stem and flower tissues. During the development of apple fruits, the expression of the MdHXK1 gene initially increased and then decreased. The changes on Glc phosphorylation relative activity and glucose concentration showed the same trend. In addition, the expression of this gene was induced by salt stress, low temperature, and abscisic acid(ABA). Finally, we obtained and purified the fused MdHXK1 protein by recombinant prokaryotic expression. Studies have demonstrated that MdHXK1 may participate in sugar metabolism in apple fruits. Enzyme encoded by MdHXK1 is a key factor in the mediation of sugar accumulation. Recently,researchers on hexokinase at home and abroad mainly focused on model plants, such as Arabidopsis, tobacco and rice, but orchard fruit like apple were underresearched. Our research established the foundation for the further study of the functions of MdHXK1. | ZHAO Jin SUN Meihong HU Dagang HAO Yujin | 2016 | Horticultural Plant Journal2016，2，2： | 4 |
| 11 | Extraction of Hemicellulose from Acacia Wood via Autohydrolysis and Ethanol Precipitation显示文摘Isolation and utilization of hemicellulose are important processes in the pulp mill-based biorefinery. Considering the potential end use of the hemicellulose,this study investigated the concentration of monomeric and oligomeric sugars in the hydrolysate derived from autohydrolysis of acacia wood and the obtainment of these sugars via ethanol precipitation. The rate of generation of monomers and oligomers increased dramatically with an increase of the temperature from 160℃ to 180℃. The maximum content of oligomers and total sugars was achieved under conditions of 180℃ and 10 min,170℃ and 85 min,respectively. Interestingly,the maximum yield of hemicellulose via ethanol precipitation was achieved in a much shorter time,compared with the maximum yield of oligomer from the hydrolysate by autohydrolysis. A 6. 66 g / L quantity of hemicellulose was obtained by intensifying the conditions of ethanol precipitation. The hemicellulose characteristics were analyzed by Fourier transform infrared,nuclear magnetic resonance,and ultraviolet spectroscopy,and the molecular weight was determined by gel permeation chromatography and thermal analysis. | HaiQiang Shi KaiYuan Guo YanNing Sun Na Li Jian Zhang MeiHong Niu QingWei Ping | 2016 | Paper And Biomaterials2016，1，1： | 4 |
| 12 | Quantum network based on non-classical light显示文摘Quantum network enables quantum communication among quantum nodes and provides advantages that are unavailable in any classical network.Based on rapidly developing science and technology in quantum communication,the studies on quantum network have also made important progresses recent years.In this study,we briefly review the experimental progresses in building quantum network based on optical field and discuss the challenges toward a quantum Internet. | Xiaolong SU Meihong WANG Zhihui YAN Xiaojun JIA Changde XIE Kunchi PENG | 2020 | Science China(Information Sciences)2020，63，8： | 3 |
| 13 | Clinical observation on pericardial effusion in patients with lung cancer treated by intrapericardial catheterization and infusion of highly agglutinative staphylococcin and cisplatin显示文摘Objective: To evaluate the therapeutic efficacy of injecting highly agglutinative staphylococcin (HASL) and cisplatin into pericardial cavity of lung cancer patients with pericardial effusion. Methods: 81 patients were randomized into two groups: 45 in the experimental group (HASL and Cisplatin) and 36 in the control group (Cisplatin). At first pericardial effusion was drained out from a intrapericardial catheter and then different drugs were infused, respectively. 24 h after perfusion the draining continued again until drainage quantity was less than 30 mL every day. The draining lasted 10–15 days. Results: The response rate was 91.1% for the experimental group and 80.6% for the control group. There was no significant difference between the two groups (P>0.05). The complete remission was 77.8% for the experimental group and 52.8% for the control group, which was statistically significant difference (P<0.05). The adverse effects were myelosuppression and nausea and vomiting, which were 35.6% and 40.0% in the experimental group and 72.2% and 66.7% in the control group, respectively (P<0.01, P<0.05). Conclusion: Inject- ing HASL and cisplatin into pericardial cavity may be a better way to control pericardial effusion of lung cancer. | Qi'an Jiang Yide Zhou Gui'e Cheng Fangyun Gong Shuyan Zhang Fengping Lang Meihong Zhao | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，5： | 3 |
| 14 | Permanence and almost periodic solution of a predator-prey discrete system with Holling IV functional response显示文摘 | Tiejun Zhou Xiaolan Zhang Meihong Xiang Zhaohua Wu | 2016 | International Journal of Biomathematics2016，9，3： | 2 |
| 15 | Improving Prediction Accuracy of a Rate-Based Model of an MEA-BasedCarbon Capture Process for Large-Scale Commercial Deployment显示文摘Carbon capture and storage (CCS) technology will play a critical role in reducing anthropogenic carbondioxide (CO2) emission from fossil-fired power plants and other energy-intensive processes. However, theincrement of energy cost caused by equipping a carbon capture process is the main barrier to its commer-cial deployment. To reduce the capital and operating costs of carbon capture, great efforts have been madeto achieve optimal design and operation through process modeling, simulation, and optimization. Accuratemodels form an essential foundation for this purpose. This paper presents a study on developing a moreaccurate rate-based model in Aspen Plus for the monoethanolamine (MEA)-based carbon capture processby multistage model validations. The modeling framework for this process was established first. The steady-state process model was then developed and validated at three stages, which included a thermodynamicmodel, physical properties calculations, and a process model at the pilot plant scale, covering a wide rangeof pressures, temperatures, and CO2 loadings. The calculation correlations of liquid density and interfacialarea were updated by coding Fortran subroutines in Aspen Plus. The validation results show that the cor-relation combination for the thermodynamic model used in this study has higher accuracy than those ofthree other key publications and the model prediction of the process model has a good agreement with thepilot plant experimental data. A case study was carried out for carbon capture from a 250 MWe combinedcycle gas turbine (CCGT) power plant. Shorter packing height and lower specific duty were achieved usingthis accurate model. | Xiaobo Luo Meihong Wang | 2017 | Engineering2017，3，2： | 2 |
| 16 | Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) inhibits platelet apoptosis in immune-induced bone marrow failure through mitochondrial pathway显示文摘OBjECTIVE: To investigate the effect of Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) on the platelet number in immune-induced bone marrow failure(BMF) and its mechanism of mitochondrial apoptotic pathway.METHODS: Immune-induced BMF model, established in mice, was randomly divided into four groups: normal control group without BMF, BMF control group, cyclosporine(CSA) group and flavone group(n = 10 in each group). Mice were given0.027 g/kg cyclosporine or 0.2 g/kg flavone lavage daily in either the cyclosporine or flavone group respectively. Platelet count, mitochondrial transmembrane potential(ΔΨm), cytochrome C(Cyt C), phosphatidylserine(PS), changes of calcium ion(Ca^(2+)),and protein expression of mitochondrial apoptotic pathway including B-cell lymphoma-2(bcl-2) Homologous Antagonist-Killer Protein(Bak), bcl-2-associated X protein(Bax), caspase-3, caspase-8, and caspase-9 were examined and compared.RESULTS: Compared with the normal control group, the BMF group had significantly lower levels of platelet count, ΔΨm, and expressions of caspase family proteins as well as higher levels of Cyt C, PS,Ca^(2+), and expressions of Bak and Bax(all P < 0.05).Compared with the BMF group, the CSA and flavone groups had significantly higher ΔΨm and expressions of caspase family proteins(all P < 0.05)whereas the levels of Cyt C, PS, Ca^(2+), and expressions of Bak and Bax were reduced(all P < 0.05).More importantly, the flavone group had higher levels of Cyt C, Ca^(2+)and expressions of Bak and Bax compared with the CSA group(all P < 0.05), while the levels of PS and caspase family proteins were reduced(all P < 0.05).CONCLUSION: Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) significantly increases the platelet number and prevents its apoptosis through mitochondrial pathway. | Jiang Yiling Zheng Qin Zhang Aiping Cui Lele Xia Lemin Luo Meihong | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 2 |
| 17 | Noninvasive Ultrasound Stimulation of Ventral Tegmental Area Induces Reanimation from General Anaesthesia in Mice显示文摘Evidence in animals suggests that deep brain stimulation or optogenetics can be used for recovery from disorders of consciousness(DOC).However,these treatments require invasive procedures.This report presents a noninvasive strategy to stimulate central nervous system neurons selectively for recovery from DOC in mice.Through the delivery of ultrasound energy to the ventral tegmental area,mice were aroused from an unconscious,anaesthetized state in this study,and this process was controlled by adjusting the ultrasound parameters.The mice in the sham group under isoflurane-induced,continuous,steady-state general anaesthesia did not regain their righting reflex.On insonation,the emergence time from inhaled isoflurane anaesthesia decreased(sham.13.63±0.53 min,ultrasound.1.5±0.19 min,p<0.001).Further,the induction time(sham.12.0±0.6 min,ultrasound.17.88±0.64 min,p<0.001)and the concentration for 50%of the maximal effect(EC50)of isoflurane(sham.0.6%,ultrasound.0.7%)increased.In addition,ultrasound stimulation reduced the recovery time in mice with traumatic brain injury(sham.30.38±1.9 min,ultrasound.7.38±1.02 min,p<0.01).This noninvasive strategy could be used on demand to promote emergence from DOC and may be a potential treatment for such disorders. | Tianyuan Bian Wen Meng Meihong Qiu Zhigang Zhong Zhengrong Lin Junjie Zou Yibo Wang Xiaowei Huang Lisheng Xu Tifei Yuan Zhili Huang Lili Niu Long Meng Hairong Zheng | 2021 | Research2021，，1： | 2 |
| 18 | Cell-death-mode switch from necrosis to apoptosis in hydrogen peroxide treated macrophages显示文摘Cell death is typically defined either as apoptosis or necrosis. Because the consequences of apoptosis and necrosis are quite different for an entire organism, the investigation of the cell-death-mode switch has considerable clinical significance. The existence of a necrosis-to-apoptosis switch induced by hydrogen peroxide in macrophage cell line RAW 264.7 cells was confirmed by using flow cytometry and fluorescence microscopy. With the help of computational simulations, this study predicted that negative feedbacks between NF-κB and MAPKs are implicated in converting necrosis into apoptosis in macrophages exposed to hydrogen peroxide, which has significant implications. | LIN XuZhu, SUN TingZhe, CAI MeiHong & SHEN PingPing* State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, School of Life Science, Nanjing University, Nanjing 210093, China | 2010 | Science China(Life Sciences)2010，53，10： | 2 |
| 19 | Quantifying quantum coherence of optical cat states显示文摘The optical cat state plays an essential role in quantum computation and quantum metrology. Here, we experimentally quantify quantum coherence of an optical cat state by means of relative entropy and the l1 norm of coherence in a Fock basis based on the prepared optical cat state at the rubidium D1 line. By transmitting the optical cat state through a lossy channel, we also demonstrate the robustness of quantum coherence of the optical cat state in the presence of loss, which is different from the decoherence properties of fidelity and Wigner function negativity of the optical cat state. Our results confirm that quantum coherence of optical cat states is robust against loss and pave the way for the application of optical cat states. | MIAO ZHANG HAIJUN KANG MEIHONG WANG FENGYI XU XIAOLONG SU KUNCHI PENG | 2021 | Photonics Research2021，9，5： | 2 |
| 20 | Advances of high-performance LiNi_(1-x-y)Co_(x)M_(y)O_(2) cathode materials and their precursor particles via co-precipitation process显示文摘Layered LiNi_(1-x-y)Co_(x)M_(y)O_(2)(M=Mn or Al)is a promising cathode material for lithium-ion batteries due to its high specific capacity and acceptable manufacturing cost.However,the polycrystalline LiNi_(1-x-y)Co_(x)M_(y)O_(2) cathode material suffers from disordered orientation of primary particles and poor geometric symmetry of secondary particles,which severely hampers the migration of Lit ions.Furthermore,the resulting anisotropy accelerates the disintegration of the secondary particle structure,significantly affecting the electrochemical performance of the polycrystalline cathode.In spite of less grain boundary,the single-crystal LiNi_(1-x-y)Co_(x)M_(y)O_(2) cathodes still suffer from severe microcracks generated by repeated planar gliding during cycling,which poses a great challenge to the cycling stability of single-crystal materials.It's worth noting that the microstructure of the cathode material is mainly inherited from its precursor.Therefore,it is necessary to deeply understand the influence of the microstructure of Ni_(1-x-y)Co_(x)M_(y)(OH)2 on the electrochemical properties of LiNi_(1-x-y)Co_(x)M_(y)O_(2) cathode materials,so as to optimize the production process of preparing high-performance cathode precursors.In this review,we summarize recent advances in the research and development of Ni-rich cathode precursor materials.Firstly,the challenges faced by the Ni-rich hydroxide precursor materials are presented,including the effect of primary particle morphology and arrangement on the electrochemical performance of cathode materials,the influence of secondary particle morphology on lithium insertion reactions in cathode,and the effect of particle size on the microcracking of single-crystal particles.Secondly,the presentation of the conventional co-precipitation reactor,the mechanism of precursor particle growth,and the influence of coprecipitation parameters are described in detail.Finally,the strategies are systematically discussed to solve the challenges of hydroxide precursors,such as the innovation and optimization on reactants,synthesis processes,and reaction equipment.To obtain satisfactory high-quality precursor materials,future work will require an in-depth understanding of the reaction mechanism,combined with simulation techniques such as flow field theory calculations to guide the synthesis of precursors.This review provides a comprehensive analysis of the current progresses on the producing technologies of highperformance cathode precursors and offers prospects for future industry developments. | Wenbiao Liang Yin Zhao Liyi Shi Zhuyi Wang Yi Wang Meihong Zhang Shuai Yuan | 2024 | Particuology2024，86，3： | 1 |
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